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Platelet-Activating Factor (PAF) Receptor in Brain and Signal Transduction in Neurons

  • Tian-Li Yue
  • Paul G. Lysko
  • Giora Feuerstein
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Specific, reversible and saturable binding sites for [3H]-PAF were observed in gerbil brain. Scatchard analysis revealed the existence of two apparent classes of binding sites with Kd1=3.7 nM and Kd2=20.4 nM. The maximal density of binding sites was found in midbrain and hippocampus (Domingo et al., 1988). The existence of specific binding sites for PAF was also shown in rat hypothalamus (Junier et al., 1988) and synaptosomes and microsomal fractions of rat cerebral cortex (Marcheselli et al., 1990).

Keywords

Global Brain Ischemia Gerbil Brain Bilateral Carotid Artery Occlusion Calcium Channel Blocker Nifedipine Rabbit Spinal Cord Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Tian-Li Yue
    • 1
  • Paul G. Lysko
    • 1
  • Giora Feuerstein
    • 1
  1. 1.Department of PharmacologySmithKline Beecham PharmaceuticalsKing of PrussiaUSA

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