Specific Binding of Tritium-Labeled Platelet-Activating Factor to Human Mononuclear Leukocyte Membranes: A Third Putative Receptor of Platelet-Activating Factor

  • San-Bao Hwang
  • My-Hanh Lam
  • Kenneth Wu
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Platelet-activating factor (PAF) is a potent phospholipid mediator with a wide spectrum of biological activities (Braquet et al., 1987; Snyder, 1989). It was initially identified as a platelet aggregating soluble product released by immunoglobulin E-sensitized rabbit basophils (Benveniste et al., 1972) and was subsequently identified as 1-0-alkyl- 2-acetyl-sn-glyceryl-3-phosphorylcholine (Demopoulos et al., 1979; Benveniste et al., 1979; Blank et al., 1979). The structural requirements for PAF biological actions are highly specific. Very low, concentrations of PAF are usually required to trigger biological effects. Also, specific desensitization takes place after exposure of cells or tissues to PAF. Specific receptors responsible for transducing a stimulatory signals within the cells are therefore suspected.

Keywords

Platelet Activate Factor Human Monocyte Human Platelet Mononuclear Leukocyte Rabbit Platelet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • San-Bao Hwang
    • 1
  • My-Hanh Lam
    • 1
  • Kenneth Wu
    • 1
  1. 1.Merck Sharp & Dohme Research LaboratoriesAtherosclerosis Research DepartmentRahwayUSA

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