Activation of Protein Kinase C Regulates LTB4 Receptor on Guinea Pig Eosinophils
The eosinophils have traditionally been viewed as a regulatory cell. It function to defend the host against parasitic infection and to contribute to the suppression of inflammatory responses by inactivating such mediators as histamine1, platelet activating factor2, and slow reacting substance of anaphylaxis3. On the other hand, data have recently accumulated to suggest that the eosinophils are active participant in the inflammatory process in such tissues as the heart4, skin5, and in particular the lungs6–8, where the products released from these cells may contribute to the pathogenesis of chronic asthma in humans. For instance, it has been demonstrated that the major basic protein (MBP), a principal protein found within the granules of the eosinophils, can cause shedding of the respiratory epithelium8. In addition, these cells can generate reactive oxygen metabolites7 and lipid mediators such as LTC 4 10 and platelet activating factor11, all of which have been implicated in the development of asthma.
KeywordsHank Balance Salt Solution Chemotactic Activity Chemotactic Response Human Eosinophil Major Basic Protein
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