Two Types of Arachidonate 12-Lipoxygenase Demonstrated by Enzymological Immunological and Molecular Biological Studies

  • Shozo Yamamoto
  • Tanihiro Yoshimoto
  • Natsuo Ueda
  • Yoshitaka Takahashi
  • Satoshi Matsuda
  • Hiroshi Suzuki
  • Takahiko Hada
  • Yasuchika Yamamoto
  • Toshiya Arakawa
  • Chieko Yokoyama
  • Tadashi Tanabe
  • Hiroyuki Toh
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Each branch of the arachidonate cascade is initiated by a lipoxygenase reaction, by which a certain carbon atom of arachidonic acid is oxygenated. Several lipoxygenases have been found in mammalian tissues, and their physiological and pathological roles have been studied (1,2). Unlike cyclooxygenase and 5-lipoxygenase, which initiate the synthesis of prostaglandins and leukotrienes, general physiological functions of other mammalian lipoxygenases remain still unclarified.

Keywords

Arachidonic Acid Human Platelet Smooth Muscle Cell Migration Lipoxygenase Product Eicosatetraenoic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Shozo Yamamoto
    • 1
  • Tanihiro Yoshimoto
    • 1
  • Natsuo Ueda
    • 1
  • Yoshitaka Takahashi
    • 1
  • Satoshi Matsuda
    • 1
  • Hiroshi Suzuki
    • 1
  • Takahiko Hada
    • 1
  • Yasuchika Yamamoto
    • 1
  • Toshiya Arakawa
    • 1
  • Chieko Yokoyama
    • 2
  • Tadashi Tanabe
    • 2
  • Hiroyuki Toh
    • 3
  1. 1.Department of BiochemistryTokushima University, School of MedicineKuramoto-cho, Tokushima 770Japan
  2. 2.Department of PharmacologyNational Cardiovascular Center, Research InstituteSuita, Osaka 565Japan
  3. 3.Protein Engineering Research InstituteSuita, Osaka 565Japan

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