Two Types of Arachidonate 12-Lipoxygenase Demonstrated by Enzymological Immunological and Molecular Biological Studies
Each branch of the arachidonate cascade is initiated by a lipoxygenase reaction, by which a certain carbon atom of arachidonic acid is oxygenated. Several lipoxygenases have been found in mammalian tissues, and their physiological and pathological roles have been studied (1,2). Unlike cyclooxygenase and 5-lipoxygenase, which initiate the synthesis of prostaglandins and leukotrienes, general physiological functions of other mammalian lipoxygenases remain still unclarified.
KeywordsArachidonic Acid Human Platelet Smooth Muscle Cell Migration Lipoxygenase Product Eicosatetraenoic Acid
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