Incorporation of Hydroxyeicosatetraenoic Acids into Phospholipid Signaling Pathways

  • Alain B. Legrand
  • John A. Lawson
  • John A. Oates
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Phosphatidylinositol (PI) and phosphatidylcholine (PC), two major membrane phospholipids (PLs), participate in cell signaling. Their hydrolysis by activated phospholipases produces second messengers, one of which is diacylglycerol (DAG), an activator of protein kinase C which is involved in a variety of cellular responses (1–5).


Phosphatidic Acid Inositol Trisphosphate Hydroxyeicosatetraenoic Acid Bovine Pulmonary Artery Endothelial Cell PHOSPHOINOSITIDE Signaling Pathway 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Alain B. Legrand
    • 1
    • 2
  • John A. Lawson
    • 1
    • 2
    • 3
  • John A. Oates
    • 1
    • 2
  1. 1.Departments of Medicine and PharmacologyVanderbilt UniversityNashvilleUSA
  2. 2.Faculté des Sciences Pharmaceutiques and BiologiquesRennesFrance
  3. 3.FarmitaliaNervianoItaly

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