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Incorporation of Hydroxyeicosatetraenoic Acids into Phospholipid Signaling Pathways

  • Alain B. Legrand
  • John A. Lawson
  • John A. Oates
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Phosphatidylinositol (PI) and phosphatidylcholine (PC), two major membrane phospholipids (PLs), participate in cell signaling. Their hydrolysis by activated phospholipases produces second messengers, one of which is diacylglycerol (DAG), an activator of protein kinase C which is involved in a variety of cellular responses (1–5).

Keywords

Phosphatidic Acid Inositol Trisphosphate Hydroxyeicosatetraenoic Acid Bovine Pulmonary Artery Endothelial Cell PHOSPHOINOSITIDE Signaling Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Alain B. Legrand
    • 1
    • 2
  • John A. Lawson
    • 1
    • 2
    • 3
  • John A. Oates
    • 1
    • 2
  1. 1.Departments of Medicine and PharmacologyVanderbilt UniversityNashvilleUSA
  2. 2.Faculté des Sciences Pharmaceutiques and BiologiquesRennesFrance
  3. 3.FarmitaliaNervianoItaly

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