Allene Oxide Biosynthesis and Metabolism

  • Wen-Chao Song
  • Alan R. Brash
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Allene oxides are reactive epoxides with a versatile chemistry.1 The name allene oxide comes from the chemical literature — the first chemical syntheses of this type of epoxide involved the oxidation of an allene, Figure 1. In biochemical systems, allene oxides are synthesized by the enzymic dehydration of hydroperoxides (lipoxygenase products), (Figure 1). Allene oxides are extremely unstable and are prone to hydrolysis and unique intramolecular rearrangements.2 While these reactions can occur in the absence of an enzymic catalyst, the naturally occurring allene oxides are substrates for enzymatic/metabolic transformations to end-products that are thought to include prostaglandins or prostaglandin-like molecules,3–5 Fig. 2.

Keywords

Jasmonic Acid Allene Oxide Acetone Powder Jasmonic Acid Biosynthesis Prostaglandin Biosynthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Wen-Chao Song
    • 1
  • Alan R. Brash
    • 1
  1. 1.Division of Clinical Pharmacology Department of PharmacologyVanderbilt UniversityNashvilleUSA

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