Biological Correlates of Suicide across the Life Span

  • Jerome A. Motto
  • Victor I. Reus


Much has been said about the psychological implications of the various stages of life as regards suicide. The life span is generally depicted as involving a dynamic, ever-changing interplay of both internal and external forces that largely determine the nature and stability of a person’s emotional experience. A major focus has been on developmental tasks and goals that, if incompletely or tardily accomplished, become an obstacle to subsequent growth, and a source of psychic pain conducive to self-destructive activity.


Suicide Attempt Suicidal Behavior Suicide Risk Thyrotropin Release Hormone Plasma Cortisol Level 
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  1. Arato, M., Banki, C., Bissette, G., & Nemeroff, C. (1989a). Elevated CSF CRF in suicide victims. Biological Psychiatry, 25, 355–359.PubMedCrossRefGoogle Scholar
  2. Arato, M., Banki, C., Tothfulusi, L., Bissette, G., Nemeroff, C., & Akil, H. (1989b, May). CSF neuropeptide changes in depression and suicide. Presented at the American Psychiatric Association Annual Meeting, San Francisco, CA.Google Scholar
  3. Agren, H. (1983). Life at risk: Markers of suicidality in depression. Psychiatric Developments, 1, 87–103.PubMedGoogle Scholar
  4. Arora, R., & Meltzer, H. (1989). Serotonergic measures in the brains of suicide victims: 5HT2 binding sites in the frontal cortex of suicide victims and control subjects. American Journal of Psychiatry, 146, 730–736.PubMedGoogle Scholar
  5. Asberg, M., Traskman, L., & Thoren, P (1976). 5-HIAA in the cerebrospinal fluid: A biochemical suicide predictor? Archives of General Psychiatry, 33, 1193–1197.PubMedCrossRefGoogle Scholar
  6. Ash, K., Clark, S., Sandberg, L., Hunter, E., & Woodward, S. (1983). The influences of sample distribution and age on reference intervals for adult males. American Journal of Clinical Pathology, 79, 574–581.PubMedGoogle Scholar
  7. Baldessarini, R. (1975). An overview of the basis for amine hypothesis in affective illness. In J. Mendels (Ed.), The psychobiology of depression. New York: Spectrum.Google Scholar
  8. Banki, C. (1985). Biochemical markers for suicidal behavior. American Journal of Psychiatry, 142, 147–148.PubMedGoogle Scholar
  9. Banki, C., & Arato, M. (1983a). Amine metabolites and neuroendocrine responses related to depression and suicide. Journal of Affective Disorders, 5, 223–232.PubMedCrossRefGoogle Scholar
  10. Banki, C., & Arato, M. (1983b). Amine metabolites, neuroendocrine findings, and personality dimensions as correlates of suicidal behavior. Psychiatry Research, 10, 253–261.PubMedCrossRefGoogle Scholar
  11. Banki, C., Arato, M., & Kiltz, C. (1986). Aminergic studies and cerebrospinal fluid cations in suicide. In J. Mann, & M. Stanley (Eds.), Psychobiology of suicidal behavior. New York: New York Academy of Sciences.Google Scholar
  12. Banki, C., Arato, M., Papp, Z., & Kurca, M. (1984). Biochemical markers in suicidal patients. Journal of Affective Disorder, 6, 341–350.CrossRefGoogle Scholar
  13. Banki, C., Vojnik, M., Papp, Z., Balla, K. Z., & Arato, M. (1985). Cerebrospinal fluid magnesium and calcium related to amine metabolites, diagnosis, and suicide attempts. Biological Psychiatry, 20, 163–171.PubMedCrossRefGoogle Scholar
  14. Berger, M., Krieg, C., Bossert, S., Schreiber, W., & von Zerssen D. (1988). Past and present strategies of research on the HPA-axis in psychiatry. Acta Psychiatrica Scandinavica, 341, 112–125.PubMedCrossRefGoogle Scholar
  15. Brown, G., Ebert, M., Goyer, P., Jimerson, D. C., Klein, W. J., Bunney, W. E., & Goodwin, F. K. (1982). Aggression, suicide, and serotonin: Relationships to CSF amine metabolites. American Journal of Psychiatry, 139, 741–746.PubMedGoogle Scholar
  16. Bunney, W. (1984, October). The future of biologic psychiatry. Paper presented at the San Diego Psychiatric Symposium. San Diego, CA.Google Scholar
  17. Bunney, W., & Fawcett, J. (1965). Possibility of a biochemical test for suicide potential. Archives of General Psychiatry, 13, 232–239.PubMedCrossRefGoogle Scholar
  18. Bunney, W., Fawcett, J., Davis, J., & Gifford, S. (1969). Further evaluation of urinary 17-hydroxycorticosteroids in suicidal patients. Archives of General Psychiatry, 21, 138–150.PubMedCrossRefGoogle Scholar
  19. Carroll, B. (1983). Neurobiologic dimensions of depression and mania. In J. Angst (Ed.), The origins of depression: Current concepts and approaches (Dahlem Conference). New York: Springer.Google Scholar
  20. Chabrol, H., Claverie, J., & Moron, P. (1983). DST, TRH test, and adolescent suicide attempts. American Journal of Psychiatry, 140, 265.PubMedGoogle Scholar
  21. Cochran, E., Robins, E., & Grote, S. (1976). Regional serotonin levels in brain: A comparison of depressive suicides and alcoholic suicides with controls. Biological Psychiatry, 11, 283–294.PubMedGoogle Scholar
  22. Coryell, W., & Schlesser, M. (1981). Suicide and the DST in unipolar depression. American Journal of Psychiatry, 138, 1120–1121.PubMedGoogle Scholar
  23. Cross, J., Cheetham, S., Crompton, M., Katona, C., & Horton, R. (1988). Brain GABA B binding sites in depressed suicide victims. Psychiatry Research, 26, 119–129.PubMedCrossRefGoogle Scholar
  24. Crumley, F. (1983). The dexamethasone suppression test and adolescent suicide attempts. Paper presented at the 16th Annual Meeting of the American Association of Suicidology, Dallas, TX.Google Scholar
  25. Davis, B., Bishop, M., & Mass, D. (1989). Clinical laboratory science: Strategies for practice. Philadelphia: Lippincott.Google Scholar
  26. Davis, K., Davis, B., Mathe, A., Mohs, R., Rothpearl, M., Levy, M., Gorman, L., & Berger, P. (1984). Age and the dexamethasone suppression test. American Journal of Psychiatry, 141, 872–874.PubMedGoogle Scholar
  27. Dilman, V., Ostrovmova, M., & Tsyrlina, E. (1979). Hypothalamic mechanisms of aging and of specific age pathology H. On the sensitivity threshold of the hypothalamic-pituitary complex to homeostatic stimuli in adaptive homeostasis. Experimental Gerontology, 14, 175–181.PubMedCrossRefGoogle Scholar
  28. Fawcett, J. (1988). Predictors of early suicide: Identification and appropriate intervention. Journal of Clinical Psychiatry, 49, 7–8.PubMedGoogle Scholar
  29. Fink, E., & Carpenter, W. (1976). Further examination of a biochemical test for suicide potential. Diseases of the Nervous System, 37, 341–343.PubMedGoogle Scholar
  30. Funkenstein, D., King, S., & Drolette, M. (1954). The direction of anger during a laboratory stress-inducing situation. Psychosomatic Medicine, 16, 404–413.PubMedGoogle Scholar
  31. Gross-Isseroff, R., Israeli, M., & Biegon, A. (1989). Autoradiographic analysis of tritiated imipramine binding in the human brain post mortem: Effects of suicide. Archives of General Psychiatry, 46, 237–241.PubMedCrossRefGoogle Scholar
  32. Hershman, J. (1978). Use of thyrotropin-release hormone in clinical medicine. Medical Clinics of North America, 62, 313–325.PubMedGoogle Scholar
  33. Jenner, D., Harrison, G., Prior, I., Leonetti, D., & Fujimoto, W. (1987). Twenty-four-hour catecholamine excretion: Relationships with age and weight. Clinica Chimica Acta, 164, 17–25.CrossRefGoogle Scholar
  34. Kierkegaard, C., & Carroll, B. (1980). Disturbances of TSH and adrenocortical disturbances in endogenous depression. Psychiatry Research, 3, 253–264.CrossRefGoogle Scholar
  35. Kocsis, J., Davis, J., Katz, M., Koslow, S., Stokes, P., Casper, R., & Redmond, D. (1985). Depressive behavior and hyperactive adrenocortical function. American Journal of Psychiatry, 142, 1291–1298.PubMedGoogle Scholar
  36. Korpi, E., Kleinman, J., Goodman, S., Phillips, I., Delisi, L., Linnoila, M., & Wyatt, R. (1986). Serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims: Comparison in chronic schizophrenic patients with suicide as cause of death. Archives of General Psychiatry, 43, 594–600.PubMedCrossRefGoogle Scholar
  37. Krieger, G. (1974). The plasma level of cortisol as a predictor of suicide. Diseases of the Nervous System, 35, 237–240.PubMedGoogle Scholar
  38. Krieger, G. (1975). Is there a biochemical predictor of suicide? Suicide and Life-Threatening behavior, 5, 228–231.Google Scholar
  39. Levy, B., & Hansen, E. (1969). Failure of the urinary test for suicide. Archives of General Psychiatry, 20, 415–418.PubMedCrossRefGoogle Scholar
  40. Lidberg, L., Tuck, J., Asberg, M., Scalia-Tomba, G., & Bertilsson, L. (1985). Homicide, suicide and CSF 5-HIAA. Acta Psychiatrica Scandinavica, 71, 230–236.PubMedCrossRefGoogle Scholar
  41. Linkowski, P., van Wettere, J., Kerkhofs, M., Brauman, H., & Mendlewicz, J. (1983). Thyrotrophin response to thyreostimulin in affectively ill women: Relationship to suicidal behavior. British Journal of Psychiatry, 143, 401–405.PubMedCrossRefGoogle Scholar
  42. Linkowski, P., van Wettere, J., Kerkhofs, M., Gregoire, F., & Brauman, H. (1984). Violent suicidal behavior and the thrytropin releasing hormone-thyroid stimulating hormone test: A clinical outcome study. Neuropsychobiology, 12, 19–22.PubMedCrossRefGoogle Scholar
  43. Loosen, P., Prange, A., & Wilson, I. (1978). Influence of cortisol on TRH-induced TSH response in depression. American Journal of Psychiatry, 135, 244–246.PubMedGoogle Scholar
  44. Manchon, M., Kopp, N., Rovzioux, J., Lecestre, D., Deluermoz, S., & Miachon, S. (1987). Benzodiazepine receptor and neurotransmitter studies in the brain of suicides. Life Sciences, 24, 2623–2630.CrossRefGoogle Scholar
  45. McGeer, E. (1978). Aging and neurotransmitter metabolism in the human brain. In R. Katzman, R. Terry, & K. Bick (Eds.), Alzheimer’s disease: Senile dementia and related disorders. New York: Raven Press.Google Scholar
  46. Meltzer, H., & Arora, R. (1986). Platelet markers of suicidality. In J. Mann & M. Stanley (Eds.), Psychobiology of suicidal behavior. New York: New York Academy of Sciences.Google Scholar
  47. Nemeroff, C. (1988). The neurobiology of aging and the neurobiology of depression: Is there a relationship? Neurobiology of Aging, 9, 122–124.CrossRefGoogle Scholar
  48. Ninan, P., van Kammen, D., Scheinen, M., Linnoila, M., Bunney, W. E., & Goodwin, F. K. (1984). CSF 5-hydroxyindoleacetic acid levels in suicidal schizophrenia patients. American Journal of Psychiatry, 141, 566–569.PubMedGoogle Scholar
  49. Oreland, L., Widberg, A., Asberg, M., Traskman, L., Sjostrand, L., Thoren, P., Bertilsson, L., & Tybring, G. (1981). Platelet MAO activity and monoamine metabolites in CSF in depressed and suicidal patients and in healthy controls. Psychiatry Research, 4, 21–29.PubMedCrossRefGoogle Scholar
  50. Ostroff, R., Giller, E., Bonese, K., Ebersole, E., Harkness, L., & Mason, J. (1982). Neuroendocrine risk factors of suicidal behavior. American Journal of Psychiatry, 139, 1323–1325.PubMedGoogle Scholar
  51. Pickar, D., Roy, A., Breier, A., Doran, A., Wolkowitz, O., Colison, J., & Agren, H. (1986). Suicide and aggression in schizophrenia. Neurobiologic correlates. Annual of New York Academy of Science, 487, 189–196.CrossRefGoogle Scholar
  52. Puig-Antich, J., Duhl, R., Ryan, N., Novacenko, H., Goetz, D., Goetz, R., Iwomey, J., & Klepper, T. (1989). Cortisol secretion in prepubertal children with major depressive disorders. Archives of General Psychiatry, 46, 801–809.PubMedCrossRefGoogle Scholar
  53. Robbins, D., & Alessi, N. (1985). Suicide and the dexamethasone suppression test in adolescence. Biological Psychiatry, 20, 107–110.PubMedCrossRefGoogle Scholar
  54. Roy, A., Agren, H., Pickar, D., Linnoila, M., Doran, A., Cutler, N., & Paul S. (1986). Reduced CSF concentrations of homovanillic acid and HVA to 5-HIAA ratios in depressed patients: Relationship to suicidal behavior and dexamethasone nonsuppression. American Journal of Psychiatry, 143, 1539–1545.PubMedGoogle Scholar
  55. Roy, A., Ninan, P., Mazonson, A., Pickar, D., van Kammen, D., Linnoila, M., & Paul, S. (1985). CSF monoamine metabolites in chronic schizophrenic patients who attempt suicide. Psychological Medicine, 15, 335–340.PubMedCrossRefGoogle Scholar
  56. Roy, A., Pickar, D., DeJong, I., Karoum, E., & Linnoila, M. (1989). Suicidal behavior in depression: Relation to noradrenergic function. Biological Psychiatry, 25, 341–350.PubMedCrossRefGoogle Scholar
  57. Sachar, E., Asnis, G., Nathan, S., Halbreich, U., Tabrizi, A., & Halpern, F. (1980). Dextroamphetamine and cortisol in depression. Archives of General Psychiatry, 37, 755–757.PubMedCrossRefGoogle Scholar
  58. Shaw, D., Camps, E., & Eccleston, E. (1967). 5-Hydroxytryptamine in the hindbrain of depressed suicides. British Journal of Psychiatry, 113, 1407–1411.PubMedCrossRefGoogle Scholar
  59. Simpkins, J. (1983). Changes in hypothalamic hypophysiotropic hormones and neurotransmitters during aging. In J. Meites (Ed.), Neuroendocrinology of aging. New York: Plenum Press.Google Scholar
  60. Snyder, P., & Utiger, R. (1972a). Response to thyrotropin releasing hormone (TRH) in normal men. Journal of Clinical Endocrinology & Metabolism, 34, 380–385.CrossRefGoogle Scholar
  61. Snyder, P., & Utiger, R. (1972b). Thyrotropin response to thyrotropin releasing hormone in normal females over forty. Journal of Clinical Endocrinology & Metabolism, 34, 1096–1098.CrossRefGoogle Scholar
  62. Stanley, M., & Stanley, B. (1989). Biochemical studies in suicide victims: Current findings and future implications. Suicide and Life-Threatening Behavior, 19, 30–42.PubMedGoogle Scholar
  63. Stanley, M., Virgilio, J., & Gershon, S. (1982). Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science, 216, 1337–1339.PubMedCrossRefGoogle Scholar
  64. Struve, F. (1979). Clinical encephalography. In L. Hankoff & B. Einsidler (Eds.), Suicide: Theory and clinical aspects. Littleton, MA: PSG.Google Scholar
  65. Struve, F., Saraf, K., Arko, R., Klein, D., & Becka D. (1977). Relationship between paroxysmal electroencephalographic dysrhythmia and suicide ideation and attempts in psychiatric patients. In C. Shogass, S. Gershon, & A. Friedhof (Eds.), Psychopathology and brain dysfunction. New York: Raven Press.Google Scholar
  66. Traskman, L., Asberg, M. Bertilsson, L., & Sjostrand, L. (1981). Monoamine metabolites in CSF and suicidal behavior. Archives of General Psychiatry, 38, 631–636.PubMedCrossRefGoogle Scholar
  67. Traskman, L., Tybring, G., Asberg, M., Bertilsson, L., Lantto, O., & Schalling, G. (1980). Cortisol in the CSF of depressed and suicidal patients. Archives of General Psychiatry, 37, 761–767.PubMedCrossRefGoogle Scholar
  68. van Praag, H. (1983). CSF 5-HIAA and suicide in nondepressed schizophrenics. Lancet, 2, 1256.Google Scholar
  69. van Praag, H. (1986). Biological suicide research: Outcome and limitations. Biological Psychiatry, 21, 1305–1323.PubMedCrossRefGoogle Scholar
  70. Veith, R., & Raskind, M. (1988). The neurobiology of aging: Does it predispose to depression? Neurobiology of Aging, 9, 101–117.PubMedCrossRefGoogle Scholar
  71. Woodman, D. (1979). Evidence of a permanent imbalance in catecholamine secretions in violent social deviants. Journal of Psychosomatic Research, 23, 155–157.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Jerome A. Motto
    • 1
  • Victor I. Reus
    • 1
  1. 1.Department of Psychiatry and Langley Porter Psychiatric InstituteUniversity of CaliforniaSan FranciscoUSA

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