Abstract
The inflammatory response is characterized by leukocyte adherence to the vessel wall and subsequent infiltration of tissue by emigrated leukocytes.1 Leukocytes contain or are capable of producing a number of products that can potentially cause cell injury or modify cell function (reviewed in Ref. 2). Consequently, many investigators have proposed a causal relationship between leukocyte accumulation at sites of inflammation or immune reaction and associated vascular and tissue injury. Leukocyte-mediated injury of vascular endothelium as an “innocent bystander” has been implicated in the pathogenesis of a wide variety of clinical disorders some of which are listed in Table 1.
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Winn, R.K., Rice, C.L., Vedder, N.B., Mileski, W.J., Harlan, J.M. (1992). Leukocyte-Mediated Endothelial Injury. In: Simionescu, N., Simionescu, M. (eds) Endothelial Cell Dysfunctions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0721-9_8
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DOI: https://doi.org/10.1007/978-1-4899-0721-9_8
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