Leukocyte-Mediated Endothelial Injury
The inflammatory response is characterized by leukocyte adherence to the vessel wall and subsequent infiltration of tissue by emigrated leukocytes.1 Leukocytes contain or are capable of producing a number of products that can potentially cause cell injury or modify cell function (reviewed in Ref. 2). Consequently, many investigators have proposed a causal relationship between leukocyte accumulation at sites of inflammation or immune reaction and associated vascular and tissue injury. Leukocyte-mediated injury of vascular endothelium as an “innocent bystander” has been implicated in the pathogenesis of a wide variety of clinical disorders some of which are listed in Table 1.
KeywordsReperfusion Injury Vascular Injury Hemorrhagic Shock Allograft Rejection Leukocyte Adherence
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