Modulation of Endothelial Paracellular Permeability

A Mechanistic Approach
  • F. R. Haselton
  • J. S. Alexander
  • S. N. Mueller
  • A. P. Fishman


Inflammatory edema is a significant element of many disease, e.g., adult respiratory distress syndrome, septicemia, and hypoxia/reperfusion syndrome. In vivo studies have sought to identify the mechanism(s) by which inflammatory mediators produce edema. However, this approach has met with limited success since edema often results from a combination of both pressure-induced filtration of plasma proteins, and changes in the permeability properties of the endothelial lining of the vascular wall.1–3


Polyethylene Glycol Phorbol Myristate Acetate Cell Column Phorbol Myristate Acetate PARACELLULAR Permeability 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • F. R. Haselton
    • 1
  • J. S. Alexander
    • 1
  • S. N. Mueller
    • 2
  • A. P. Fishman
    • 3
  1. 1.Department of Biomedical EngineeringVanderbilt UniversityNashvilleUSA
  2. 2.Coriell Institute for Medical ResearchCamdenUSA
  3. 3.Cardiovascular-Pulmonary Division, Department of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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