Endothelial Cell Regrowth

  • Michael A. Reidy
  • Volkhard Lindner


Endothelial cells, either in vivo or in vitro, grow as a monolayer and despite their key location in blood vessels and the important functions which they carry out, we know relatively little about the mechanisms which control their growth in vivo.1–3 This is perhaps because most endothelial cells, at least in vitro, were found to grow readily and little attention was given to understanding what factors might influence this process. The widespread use of vascular grafting and the discovery that reendothelialization is often severely limited,4–8 however, clearly demonstrate that endothelial growth and maintenance of an intact endothelial monolayer are not simple automatic processes. In this chapter we will discuss those experiments which have focused on understanding what factors are important in controlling endothelial cell replication and whether these factors can influence endothelial cell growth in the denuded blood vessel.


Endothelial Cell Smooth Muscle Cell Balloon Catheter Basic Fibroblast Growth Factor Endothelial Cell Growth 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Michael A. Reidy
    • 1
  • Volkhard Lindner
    • 1
  1. 1.Department of PathologyUniversity of WashingtonSeattleUSA

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