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Role of the Vascular Endothelium in Cancer Metastasis

  • Chapter
Endothelial Cell Dysfunctions

Abstract

The overwhelming majority of patients who die from cancer do so because of metastatic disease. The prevention of cancer deaths is therefore dependent on understanding the mechanism of malignant tumor cell spread from primary tumor sites to distant organ sites. Cancer metastases form by way of a complex series of sequential steps involving a variety of tumor cell and host properties. These steps typically involve growth and invasion of malignant cells at primary sties, followed by their penetration of the lymphatics, the circulatory system, and body cavities. Once in this compartments, the malignant cells can detach and be transported to distant sites. There they can implant and invade surrounding tissues and establish suitable microenvironments for survival and growth.

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References

  1. Sugarbaker, E. V., 1981, Patterns of metastasis, Cancer Biol. Rev. 2: 235–278.

    Google Scholar 

  2. Nicolson, G. L., 1982, Cancer metastasis: Organ colonization and the cell-surface properties of malignant cells, Biochim. Biophys. Acta 695: 113–176.

    PubMed  CAS  Google Scholar 

  3. Naito, S., von Eschenbach, A. C., and Fidler, I. J., 1987, Different growth pattern and biologic behavior of human renal cell carcinoma implanted into different organs of nude mice, J. Natl. Cancer Inst. 78: 377–385.

    PubMed  CAS  Google Scholar 

  4. Murphy, P., Alexander, P., Senior, P. V., Flemming, J., Kirkham, N., and Taylor, I., 1988, Mechanisms of organ selective tumour growth by blood-borne cancer cells, Br. J. Cancer 57: 19–31.

    Article  PubMed  CAS  Google Scholar 

  5. Nicolson, G. L., 1988, Organ specificity of tumor metastasis: Role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites, Cancer Metastasis Rev. 7: 143–188.

    Article  PubMed  CAS  Google Scholar 

  6. Auerbach, R., Lu, W., Pardon, E., Gukowski, F., Kaminska, G., and Kaminska, M., 1987, Specificity of adhesion between murine tumor cells and capillary endothelium: An in vitro correlate of preferential metastasis in vivo, Cancer Res. 47: 1492–1496.

    CAS  Google Scholar 

  7. Ewing, J., 1928, A treatise on tumors, in: Neoplastic Diseases, 3rd ed., Saunders, Philadelphia.

    Google Scholar 

  8. Paget, S., 1889, The distribution of secondary growths in cancer of the breast, Lancet 1: 571–573.

    Article  Google Scholar 

  9. Weiss, L., 1983, Random and nonrandom processes in metastasis, and metastatic efficiency, Invasion Metastasis 3: 193–208.

    PubMed  CAS  Google Scholar 

  10. Irimura, T., and Nicolson, G. L., 1984, Carbohydrate chain analysis by lectin binding to mixtures of glycoproteins separated by Polyacrylamide slab-gel electrophoresis with in situ chemical modification, Carhohydr. Res. 115: 209–220.

    Article  Google Scholar 

  11. Hart, I. R., 1982, The role of animal models in the study of experimental metastasis, in: Tumor Invasion and Metastasis (L. Liotta and I. R. Hart, eds.), Nijhoff, The Hague, pp. 1–14.

    Chapter  Google Scholar 

  12. Hart, I. R., and Fidler, I. J., 1980, The role of organ selectivity in the determination of metastatic patterns of B16 melanoma, Cancer Res. 40: 2281–2287.

    PubMed  CAS  Google Scholar 

  13. Roos, E., Middlekoop, O. P., and Van de Pavert, I. V., 1984, Adhesion of tumor cells to hepatocytes: Different mechanisms for mammary carcinoma compared with lymphosarcoma cells, J. Natl. Cancer Inst. 73: 963–969.

    PubMed  CAS  Google Scholar 

  14. Belloni, P. N., and Tressler, R.J., 1990, Microvascular heterogeneity: Interactions with leukocytes and tumor cells, Cancer Metastasis Rev. 8: 353–389.

    Article  PubMed  CAS  Google Scholar 

  15. Ford, W. L., 1973, The cellular basis for immune responses, in: Defense and Recognition (R. Porter, ed.), Butterworths, London, pp. 65–102.

    Google Scholar 

  16. Ford, W. D., Sedgely, M., and Smith, M. E., 1976, The migration of lymphocytes across specialized endothelium, Cell Tissue Kinet. 9: 351–361.

    PubMed  CAS  Google Scholar 

  17. Gowans, J. L., and Knight, E. J., 1964, The route of recirculation of lymphocytes in the rat, Proc. R. Soc. London 159: 275–282.

    Article  Google Scholar 

  18. Stamper, H. B., and Woodruff, J. J., 1976, Lymphocyte homing into lymph nodes: In vitro demonstration of the selective affinity of recirculating lymphocytes for HEV, J. Exp. Med. 144: 828–841.

    Article  PubMed  Google Scholar 

  19. Dujvestijn, A. M., Kerkhove, M., Bargatze, R. F., and Butcher, E. C., 1987, Lymphoid tissue and inflammation specific endothelial cell differentiation defined by monoclonal antibodies, J. Immunol. 138: 713–719.

    Google Scholar 

  20. Gallatin, W. M., Weissman, I. L., and Butcher, E. C., 1983, A cell surface molecule involved in organ-specific homing of lymphocytes, Nature 304: 30–34.

    Article  PubMed  CAS  Google Scholar 

  21. Streeter, P. R. Lakey-Berg, E., Rouse, B., Bargatze, R., and Butcher, E. C., 1988, A tissue specific endothelial cell molecule involved in lymphocyte homing, Nature 331: 41–46.

    Article  PubMed  CAS  Google Scholar 

  22. Streeter, P. R., Rouse, B. T., and Butcher, E. C., 1988, Immunohistologic and functional characterization of vascular addressin involved in lymphocyte homing into peripheral lymph nodes, J. Cell Biol. 107: 1853–1862.

    Article  PubMed  CAS  Google Scholar 

  23. deBono, D., 1977, Lymphocytes and the microcirculation, Adv. Microcirc. 7: 68–95.

    Google Scholar 

  24. Weiss, L., Orr, F. W., and Honn, K. V., 1988, Interaction of cancer cells with the microvasculature during metastasis, FASEB J. 2: 12–21.

    PubMed  CAS  Google Scholar 

  25. Tressler, R. J., Belloni, P. N., and Nicolson, G. L., 1989, Correlation of inhibition of tumor cell-endothelial cell adhesion by RGD-containing peptide polymers and metastatic potential: Role of integrin-dependent and -independent adhesion mechanisms, Cancer Commun. 1: 55–63.

    PubMed  CAS  Google Scholar 

  26. Greene, H. S., and Harvey, E. K., 1964, The relationship between the dissemination of tumor cells and the distribution of metastases, Cancer Res. 24: 799–811.

    PubMed  CAS  Google Scholar 

  27. Nicolson, G. L., and Winkelhake, J. L., 1975, Organ specificity of blood-borne tumour metastasis determined by cell adhesion? Nature 255: 230–234.

    Article  PubMed  CAS  Google Scholar 

  28. Nicolson, G. L., 1982, Metastatic tumor cell attachment and invasion assay utilizing vascular endothelial cell monolayers, J. Histochem. Cytochem. 30: 214–220.

    Article  PubMed  CAS  Google Scholar 

  29. Tressler, R. J., and Nicolson, G. L., 1991, Butanol-extractable and detergent-solubilized cell surface components from murine large cell lymphoma cells associated with adhesion to organ microvessel endothelial cells, J. Cell. Biochem. in press.

    Google Scholar 

  30. Rhoden, L., 1980, Structure and metabolism of connective tissue proteoglycans, in: The Biochemistry of Proteoglycans (W. J. Lennarz, ed.), Plenum Press, New York, pp. 180–221.

    Google Scholar 

  31. Majno, G., 1965, Ultrastructure of the vascular membrane, in: Handbook of Physiology: Circulation, Vol. III, pp. 2293–2375.

    Google Scholar 

  32. Stemmerman, M. B., 1980, General properties of blood vessels: Vascular endothelia, in: Blood Vessels and Lymphatics in Organ Systems (D. Abramson and P. Dobrin, eds.), Academic Press, New York, pp. 25–31.

    Google Scholar 

  33. Timpl, R., and Martin, G. R., 1982, Components of basement membranes, in Immunochemistry of the Extracellular Matrix (H. Furthmayer, ed.), CRC Press, Boca Raton, pp. 119–150.

    Google Scholar 

  34. Carley, W. W., Milici, A. J., and Madri, J. A., 1988, Extracellular matrix specificity for the differentiation of capillary endothelial cells, Exp. Cell Res. 178: 426–434.

    Article  PubMed  CAS  Google Scholar 

  35. Kefalides, N. A., 1975, Basement membranes: Structural and biosynthetic considerations, J. Invest. Dermatol. 65: 85–92.

    Article  PubMed  CAS  Google Scholar 

  36. Madri, J. A., and Pratt, B. M., 1986, Endothelial cell-matrix interactions: In vitro models of angiogenesis, J. Histochem. Cytochem. 34: 85–91.

    Article  PubMed  CAS  Google Scholar 

  37. Wang, Z. W., Irimura, T., Nakajima, M., Belloni, P. N., and Nicolson, G. L., 1985, Characterization of the ECM associated GAG produced by untransformed and transformed bovine corneal endothelial cells in culture, Eur. J. Biochem. 153: 125–130.

    Article  PubMed  CAS  Google Scholar 

  38. Gospodarowicz, D., Gonzalez, R., and Fujii, D., 1983, Are factors originating from serum, plasma, or cultured cells involved in the growth promoting effect of the ECM produced by cultured bovine corneal endothelial cells? J. Cell. Physiol. 114: 191–199.

    Article  PubMed  CAS  Google Scholar 

  39. Vlodavsky, I., Folkman, J., and Klagsburn, M., 1987, Heparin-binding endothelial cell growth factors are sequestered by the extracellular matrix, in: Angiogenesis: Mechanisms and Pathology (D. B. Rifkin and M. Klagsburn, eds.), Cold Spring Harbor Laboratories, Cold Spring Harbor, N.Y., pp. 58–64.

    Google Scholar 

  40. Liotta, L. A., Rao, C. N., and Barsky, S. H., 1983, Tumor invasion and the extracellular matrix, Lab. Invest. 49: 636–649.

    PubMed  CAS  Google Scholar 

  41. Nakajima, M., Irimura, T., and Nicolson, G. L., 1987, Basement membranes degradative enzymes and tumor metastasis, Cancer Bull. 39: 142–149.

    Google Scholar 

  42. Simionescu, M., Simionescu, N., and Palade, G., 1981, Differentiated microdomains on the luminal surfaces of capillary endothelium, J. Cell Biol. 90: 605–613.

    Article  PubMed  CAS  Google Scholar 

  43. Simionescu, M., Simionescu, N., Silbert, E., and Palade, G., 1981, Differential microdomains on the luminal surfaces of capillary endothelium. II. Partial characterization of their anionic sites, J. Cell Biol. 90: 614–621.

    Article  PubMed  CAS  Google Scholar 

  44. Simionescu, M., and Simionescu, N., 1980, Hydrophobic pathways of capillary endothelium, a dynamic system, in: Alfred Benson Symposium15 (H. H. Ussing, N. B. Bindilev, and O. Sten-Knudsen, eds.), Munksgaard, Copenhagen, pp. 1–21.

    Google Scholar 

  45. Simionescu, M., Simionescu, N., and Palade, G., 1982, Differential microdomains on the luminal surface of capillary endothelium: Distribution of lectin receptors, J. Cell Biol. 94: 406–413.

    Article  PubMed  CAS  Google Scholar 

  46. Simionescu, M., Simionescu, N., and Palade, G., 1982, Preferential distribution of anionic sites on the basement membrane and abluminal aspect in fenestrated endothelium, J. Cell Biol. 95: 425–434.

    Article  PubMed  CAS  Google Scholar 

  47. Simionescu, M., Simionescu, N., Santoro, F., and Palade, G., 1985, Differentiated microdomains of the luminal plasmalemma of murine muscle capillaries: Segmental variations in young and old, J. Cell Biol. 100: 1296–1307.

    Article  Google Scholar 

  48. Bankston, P. W., and Milici, A. J., 1983, A survey of the binding of polycationic ferritin in several fenestrated capillary beds. Indication of heterogeneity in the luminal glycocalyx of fenestrated diaphragms, Microvasc. Res. 26: 36–48.

    Article  PubMed  CAS  Google Scholar 

  49. Born, G. V. R., and Palinski, D., 1985, Unusually high concentrations of sialic acid on the surface of vascular endothelia, Br. J. Exp. Pathol. 66: 543–549.

    PubMed  CAS  Google Scholar 

  50. Soda, R., and Tavassolli, M., 1983, Mapping of the bone marrow sinus endothelium with lectins and glycosylated ferritins: Identification of different microdomains and their functional significance, J. Ultra-struct. Res. 84: 299–310.

    Article  CAS  Google Scholar 

  51. Pino, R. M., 1984, Ultrastructural localization of lectin receptors on the bone marrow sinusoidal endothelium of the rat, Am. J. Anat. 169: 259–272.

    Article  PubMed  CAS  Google Scholar 

  52. Vorbrodt, A. W., Dobrogowska, D. H., Lossinsky, A. S., and Wisniewski, H. M., 1986, Ultrastructural localization of lectin receptors on the luminal and abluminal aspects of brain micro-blood vessels, J. Histochem. Cytochem. 34: 251–261.

    Article  PubMed  CAS  Google Scholar 

  53. Vorbrodt, A. W., 1986, Changes in the distribution of endothelial surface glycoconjugates associated with altered permeability of brain blood vessels, Acta Neuropathol. 70: 103–111.

    Article  PubMed  CAS  Google Scholar 

  54. Ponder, B. A., and Wilkinson, M. M., 1983, Organ related differences of Dolichos biflorus agglutinin to vascular endothelium, Dev. Biol. 96: 535–544.

    Article  PubMed  CAS  Google Scholar 

  55. Belloni, P. N., and Nicolson, G. L., 1988, Differential expression of cell surface glycoproteins on various organ-derived microvascular endothelia and endothelial cell cultures, J. Cell. Physiol. 136: 398–410.

    Article  PubMed  CAS  Google Scholar 

  56. Fatehi, M. I., Gerhurt, D. Z., Myers, T. G., and Drews, L. R., 1987, Characterization of the blood-brain barrier: Glycoconjugate receptors of 14 lectins in canine brain, cultured endothelial cells and blotted membrane proteins, Brain Res. 415: 30–39.

    Article  PubMed  CAS  Google Scholar 

  57. Belloni, P.N., and Nicolson, G. L., 1988, Biochemical and immunological detection of organ specific glycoproteins associated with the blood brain barrier, Biology of the Vascular Endothelial Cell Vth Symp. (Abstract) VI–3.

    Google Scholar 

  58. Holthoffer, H., Virtanen, I., Kariniemi, A. L., Hormonia, M., Linder, E., and Miettinen, A., 1982, Ulex europeus I lectin as a marker for vascular endothelium in human tissue, Lab. Invest. 47: 60–66.

    Google Scholar 

  59. Alroy, J., Goyal, V., and Skutelsky, E., 1987, Lectin histochemistry of mammalian endothelium, Histochemistry 86: 603–607.

    Article  PubMed  CAS  Google Scholar 

  60. Laitinen, L., 1987, Griffonia simplicifolia lectins bind specifically to endothelial cells and some epithelial cells in mouse tissues, Histochem. J. 19: 225–234.

    Article  PubMed  CAS  Google Scholar 

  61. Pressman, D., 1955, Tissue localizing antibodies, Ann. N.Y. Acad. Sci. 59: 376–379.

    Article  PubMed  CAS  Google Scholar 

  62. Pressman, D., 1964, Certain aspects of tissue specific antigens, Can. Cancer Conf. 5: 363–376.

    Google Scholar 

  63. Auerbach, R., Alby, L., Morissey, L., Tu, M., and Joseph, J., 1985, Expression of organ-specific antigens on capillary endothelial cells, Microvasc. Res. 29: 401–406.

    Article  PubMed  CAS  Google Scholar 

  64. Ghandour, M. S., Langley, O. K., Gombos, G., Hirn, M., Hirsch, M. R., and Goridis, C. A., 1982, A surface marker for murine vascular endothelial cells defined by monoclonal antibody, J. Histochem. Cytochem. 30: 165–170.

    Article  PubMed  CAS  Google Scholar 

  65. Zanetta, J. P., Dontenwill, M., Meyer, A., and Roussel, G., 1985, Isolation and immunohistochemical localization of a lectin-like molecule from rat cerebellum, Dev. Brain Res. 17: 233–243.

    Article  CAS  Google Scholar 

  66. Michalak, T., White, F. P., Gard, A. L., and Dutton, G. R., 1986, A monoclonal antibody to the endothelium of rat brain microvessel, Brain Res. 379: 320–328.

    Article  PubMed  CAS  Google Scholar 

  67. Partridge, W. M., Yang, J., Eisenberg, J., and Mietus, L. J., 1986, Antibodies to blood-brain barrier bind selectively to brain capillary endothelial lateral membranes and to a 46K protein, J. Cereb. Blood Flow Metab. 6: 203–211.

    Article  Google Scholar 

  68. Risau, W., Hallman, R. Albrecht, U., and Henke-Fahle, S., 1986, Brain induces the expression of an early cell surface marker for blood-brain barrier-specific endothelium, EMBO J. 5: 3179–3183.

    PubMed  CAS  Google Scholar 

  69. Hogg, N., MacDonald, S., Slusarenky, M., and Beverly, P. C., 1984, Monoclonal antibody specific for human monocytes, granulocytes and endothelium, Immunology 53: 753–767.

    PubMed  CAS  Google Scholar 

  70. Flotte, T. J., Springer, T. A., and Thorbecke, G. J., 1983, Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets, Am. J. Pathol. 111: 112–119.

    PubMed  CAS  Google Scholar 

  71. Paul, L.C., Baldwin, W. M., and van Es, L. S., 1985, Vascular endothelial alloantigens in renal transplantation, Transplantation 40: 117–123.

    Article  PubMed  CAS  Google Scholar 

  72. Blankert, J. J., Paul, L. C., and van Es, L. A., 1985, Immunogenicity of various organs and genetic control of the response to a non-MHC endothelial antigen in rat, Transplant. Proc. 17: 785–791.

    Google Scholar 

  73. Kennel, S. J., 1987, Rat monoclonal antibodies to mouse lung components for analysis of fibrosis, Exp. Mol. Pathol. 47: 110–124.

    Article  PubMed  CAS  Google Scholar 

  74. Kennel, S. J., Lankford, T. K., Ullrich, R. L., and Jamashbi, R. J., 1988, Enhancement of lung tumor colony formation by treatment of mice with monoclonal antibodies to pulmonary capillary endothelial cells, Cancer Res. 48: 4964–4968.

    PubMed  CAS  Google Scholar 

  75. Moore, M. G., Chrzanowski, R. R., McCormick, J. R., and Schwink, A., 1984, Production of monoclonal antibodies to rat lung angiotensin-converting enzyme, Clin. Immunol. Immunopathol. 33: 301–305.

    Article  PubMed  CAS  Google Scholar 

  76. Irving, M. G., Roll, F. J., Huang, S., and Montgomery-Bissel, D., 1984, Characterization and culture of sinusoidal endothelium from normal rat liver; lipoprotein uptake and collagen phenotype, Gastroenterology 82: 1203–1217.

    Google Scholar 

  77. Mukai, K., Rosai, J., and Burgdorf, W. H. C., 1980, Localizing of factor VIII related antigen in vascular endothelial cells using immunoperoxidase method, Am. J. Surg. Pathol. 4: 273–280.

    Article  PubMed  CAS  Google Scholar 

  78. Harrach, H. R., Jasani, B., and Williams, E. D., 1983, Factor VIII as a marker of endothelial cells in follicular carcinoma of the thyroid, J. Clin. Pathol. 36: 1050–1058.

    Article  Google Scholar 

  79. Dustin, M. L., Rothlein, R., Bhan, A. K., Dinarello, C. A., and Springer, T. A., 1986, Induction by IL-1 and interferon-7 tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1), J. Immunol. 37: 245–254.

    Google Scholar 

  80. Bevilacqua, M. P., Pober, J. S., Mendrick, D. L., Cotran, R. S., and Gimbrone, M. A., 1987, Identification of an inducible endothelia-leukocyte adhesion molecule, Proc. Natl. Acad. Sci. USA 84: 9238–9242.

    Article  PubMed  CAS  Google Scholar 

  81. Shepro, D., and Dunham, B., 1986, Endothelial cell metabolism of biogenic amines, Annu. Rev. Physiol. 48: 335–368.

    Article  PubMed  CAS  Google Scholar 

  82. Zetter, B. R., 1988, Endothelial heterogeneity: Influence of vessel size, organ location, and species specificity, in: Biology of Vascular Endothelial Cells (U. Ryan, ed.), CRC Press, Boca Raton, pp. 63–80.

    Google Scholar 

  83. Grega, G. J., Svensjo, E., and Haddy, F., 1981, Macromolecular permeability of the microvascular membrane: Physiological and pharmacological regulation, Microcirculation 1: 325–341.

    Google Scholar 

  84. Schneeberger, E. E., 1982, Circulating proteins and macromolecular transport across continuous nonfenestrated endothelium, Ann. N.Y. Acad. Sci. 401: 25–37.

    Article  PubMed  CAS  Google Scholar 

  85. Svensjo, E., and Roempke, K., 1984, Microvascular aspects of edema formation and its inhibition by β-receptor stimulants and some other anti-inflammatory drugs, in: Progress in Microcirculation II (E C. Courtice, D. G., Garlick, and M. A. Perry, eds.), University of New South Wales, pp. 447–463.

    Google Scholar 

  86. Robertson, A. L., and Rosen, L. A., 1977, The arterial endothelium: Characteristics and function of the endothelial lining of large arteries, in: Microcirculation (G. Kaley and B. M. Altura, eds.), University Park Press, Baltimore, pp. 145–165.

    Google Scholar 

  87. Huttner, I., Boufet, M., and More, R. H., 1973, Studies on protein passage through arterial endothelium. H. Regional differences in permeability to fine structural protein tracers in arterial endothelium of normo-tensive rats, Lab. Invest. 28: 678–685.

    PubMed  CAS  Google Scholar 

  88. Thorgeirsson, G., and Robertson, A. L., 1978, The vascular endothelium: Pathobiologic significance, Am. J. Pathol. 93: 802–848.

    Google Scholar 

  89. Albelda, S. M., Sampson, P. M., Hastelton, F. R., McNiff, J. M., Mueller, S. N., Williams, S. K., Fishman, A. P., and Levine, E.M., 1988, Permeability characteristics of cultured endothelial cell monolayers, J. Appl. Physiol. 64: 308–322.

    PubMed  CAS  Google Scholar 

  90. DelVecchio, P. J., Siflinger-Birnboim, A., Shepard, J. M., Bizios, R., Cooper, J. A., and Malik, A. B., 1987, Endothelial monolayer permeability to macromolecules, Fed. Proc. 46: 2511–2515.

    CAS  Google Scholar 

  91. Klatzo, I., 1967, Neuropathological aspects of brain edema, J. Neuropathol. Exp. Neurol. 26: 1–14.

    Article  PubMed  CAS  Google Scholar 

  92. Groothuis, D. R., and Vick, N. A., 1982, Brain tumors and the blood-brain barrier, Trends Neurosci. 5: 232–235.

    Article  Google Scholar 

  93. Long, D. M., 1979, Capillary ultrastructure and the blood-brain barrier in human malignant tumors, J. Neurosurg. 51: 53–58.

    Article  PubMed  CAS  Google Scholar 

  94. Roy, S., and Chitra, S., 1989, Ultrastructural study of microblood vessels in human brain tumors and peritumora tissue, J. NeuroOncol. 7: 283–294.

    Article  PubMed  CAS  Google Scholar 

  95. Criscuolo, G. R., Merrill, M. J., and Oldfield, E. H., 1988, Further characterization of malignant gliomaderived vascular permeability factor, J. Neurosurg. 69: 254–262.

    Article  PubMed  CAS  Google Scholar 

  96. Belloni, P.N., Ohigashi, H., and Nicolson, G. L., 1990, Human melanoma-derived factors increase brain microvascular permeability, in preparation.

    Google Scholar 

  97. Nemerson, Y., 1966, The reaction between brain tissue factor and factor VII and J., Biochemistry 5: 601–606.

    Article  PubMed  CAS  Google Scholar 

  98. Gonmori, H., and Takeda, Y., 1976, Properties of human tissue thromboplastin from brain, lung and placenta, Thromb. Haemostas. 36: 90–103.

    CAS  Google Scholar 

  99. Colucci, M., Balconi, R., Lorenzel, A., Pietra, D., and Semarara, N., 1983, Cultured endothelial cells generate tissue factor in response to endotoxin, J. Clin. Invest. 71: 1893–1901.

    Article  PubMed  CAS  Google Scholar 

  100. Bevilacqua, M. P., Pober, J. S., Wheeler, M. E., Cotran, R. S., and Gimbrone, M. A., 1985, Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity, Am. J. Pathol. 121: 393–403.

    Google Scholar 

  101. Bevilacqua, M. P., Pober, J. S., Majeua, G. R., Fiers, W., Cotran, R. S., and Gimbrone, M. A., 1986, Recombinant TNF induce procoagulant activity in cultured human endothelia; Characterization and comparison with the actions of IL-1, Proc. Natl. Acad. Sci. USA 83: 4533–4541.

    Article  PubMed  CAS  Google Scholar 

  102. Hoyer, L. W., Santos, R., and Hoyer, J. R., 1973, Antihemophilic factor antigen. Localization in endothelial cells by immunofluorescent microscopy, J. Clin. Invest. 52: 2737–2744.

    Article  PubMed  CAS  Google Scholar 

  103. Jaffe, E., 1984, Synthesis of factor VIII by endothelial cells, in: Biology of Endothelial Cells, Nijhoff, The Hague, pp. 209–214.

    Chapter  Google Scholar 

  104. Kwast, T. H., Stel, H. V., Cristen, E., Bertina, R. M., and Veerman, E. C., 1986, Localization of FVIII-procoagulant antigen, Blood 67: 222–227.

    PubMed  Google Scholar 

  105. Ruggeri, Z. M., DeMarco, L., Gatti, L., Bader, R., and Montgomery, R. R., 1983, Platelets have more than one binding site for VonWillebrand factor, J. Clin. Invest. 72: 1–12.

    Article  PubMed  CAS  Google Scholar 

  106. Plow, E. F., Piersbacher, M. D., Ruoslahti, E., Marguerie, G. A., and Ginsberg, M. H., 1985, The effect of Arg-Gly-Asp-containing peptides on fibrinogen and Von Willebrand factor binding to platelets, Proc. Natl. Acad. Sci. USA 82: 8057–8062.

    Article  PubMed  CAS  Google Scholar 

  107. Hoyer, L. W., 1981, The factor VIII complex: Structure and function, Blood 58: 1–13.

    PubMed  CAS  Google Scholar 

  108. Hormonia, M., Lento, V. P., and Virtanen, I., 1984, Intracellular localization of factor VIII-RAg and fibronectin in cultured human endothelial cells, Eur. J. Cell Biol. 33: 217–228.

    Google Scholar 

  109. Zetter, B. R., 1981, The endothelial cells of large and small blood vessels, Diabetes 30: 244–248.

    Google Scholar 

  110. Hormonia, M., 1982, Expression of factor VIII-related antigen and UEA lectin binding sites in endothelial cells during long-term culture, Cell Biol. Int. Rep. 6: 1123–1134.

    Article  Google Scholar 

  111. Dejana, E., Lampugnani, M. G., Giorgio, M., Gaboli, M., Federici, A.B., Ruggeri, Z. M., and Marchisio, P. C., 1989, VonWillebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism, J. Cell Biol. 109: 367–375.

    Article  PubMed  CAS  Google Scholar 

  112. Hong, S. L., 1980, Effect of bradykinin and thrombin on PGI synthesis in endothelial cells from calf and pig aorta and human umbilical cord vein, Thromb. Res. 18: 787–795.

    Article  PubMed  CAS  Google Scholar 

  113. Goldsmith, J. C., and Kisker, C.T., 1982, Thrombin-endothelial cell interactions: Critical importance of vessel origin, Thromb. Res. 25: 131–136.

    Article  PubMed  CAS  Google Scholar 

  114. Sun, F. F., and Taylor, B. M., 1978, Metabolism of prostacyclin in rat, Biochemistry 17: 4996–5000.

    Article  Google Scholar 

  115. Dusting, G. J., Moncada, S., and Vane, J. R., 1978, Recirculation of prostacyclin (PGI2) in the lung, Br. J. Pharmacol. 64: 315–319.

    Article  PubMed  CAS  Google Scholar 

  116. Johnson, A. R., 1980, Human pulmonary endothelial cells in culture: Activities of cells from arteries and veins, J. Clin. Invest. 65: 841–849.

    Article  PubMed  CAS  Google Scholar 

  117. Mosher, D. F., Doyle, M. J., and Jaffe, E. A., 1982, Synthesis and secretion of thrombospondin by cultured human endothelia cells, J. Cell Biol. 93: 343–348.

    Article  PubMed  CAS  Google Scholar 

  118. Kefalides, N. A., 1980, Chemistry of basement membranes: Structure and biosynthesis, in: Vascular Endothelium and Basement Membranes (B. M. Alttura, E. Davis, and H. Harder, eds.), Karger, Basel, pp. 295–322.

    Google Scholar 

  119. Sage, H., 1984, Collagen synthesis by endothelial cells in culture, in: Biology of Endothelial Cells (E. Jaffe, ed.), Nijhoff, The Hague, pp. 161–177.

    Chapter  Google Scholar 

  120. Madri, J. A., Dreyer, B., Pitlick, A., and Furthmeyer, H., 1980, The collagenous components of the subendothelium—Correlation of structure and function, Lab. Invest. 43: 303–315.

    PubMed  CAS  Google Scholar 

  121. Belloni, P. N., Carney, D. H., and Nicolson, G. L., 1991, Organ-derived endothelial cells express differential responsiveness to thrombin and other growth factors, Microvasc. Res. in press.

    Google Scholar 

  122. Maciag, T., Hoover, G. A., and Stemmerman, M. B., 1981, Serial propagation of human endothelial cells in vitro, J. Cell Biol. 91: 420–426.

    Article  CAS  Google Scholar 

  123. Hormonia, M., 1982, Expression of factor Vlll-related antigen and UEA lectin binding sites in endothelial cells during long-term culture, Cell Biol. Int. Rep. 6: 1123–1134.

    Article  Google Scholar 

  124. Pitas, R. E., Boyles, J., Mahley, R. W., and Montgomery-Bissell, D., 1985, Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells, J. Cell Biol. 100: 103–117.

    Article  PubMed  CAS  Google Scholar 

  125. Rupnick, M. A., Carey, A., and Williams, S. K., 1988, Phenotypic diversity in cultured cerebral microvascular endothelial cells, In Vitro 24: 435–444.

    CAS  Google Scholar 

  126. Del Regato, D., 1977, Pathways of metastatic spread of malignant tumors, Semin. Oncol. 4: 33–38.

    PubMed  CAS  Google Scholar 

  127. Fidler, I. J., and Nicolson, G. L., 1981, Immunobiology of experimental metastatic melanoma, Cancer Biol. Rev. 2: 171–234.

    Google Scholar 

  128. Viadana, E., Bross, I. D. J., and Pickren, J. E., 1973, An autopsy study of some routes of dissemination, Br. J. Cancer 27: 336–340.

    Article  PubMed  CAS  Google Scholar 

  129. Hansen, H. H., and Muggia, F. M., 1972, Staging of inoperable patients with bronchogenic carcinoma with special reference to bone marrow examination, Cancer 30: 1395–1401.

    Article  PubMed  CAS  Google Scholar 

  130. Elliott, R. H. E., and Frantz, V.K., 1960, Metastatic carcinoma masquerading as primary thyroid cancer: A report of authors’ 14 cases, Ann. Surg. 151: 551–561.

    Article  PubMed  Google Scholar 

  131. Prout, G. R., 1973, Prostate gland, in: Cancer Medicine (J. F. Holland and E. Frei, eds.), Lea & Febiger, Philadelphia, pp. 1680–1694.

    Google Scholar 

  132. Fidler, I. J., and Nicholson, G. L., 1976, Organ selectivity for implantation, survival, and growth of B16 melanoma variant tumor lines, J. Natl. Cancer Inst. 57: 1199–1202.

    PubMed  CAS  Google Scholar 

  133. Brunson, K. W., Beatty, G., and Nicolson, G. L., 1978, Selection and altered tumor cell properties of brain colonizing metastatic melanoma, Nature 272: 543–545.

    Article  PubMed  CAS  Google Scholar 

  134. Nicolson, G. L., Miner, K. M., and Reading, C. L., 1981, Tumor cell heterogeneity and blood-borne metastasis, in: Fundamental Mechanisms in Human Cancer Immunology (J. Saunders, J. Daniels, B. Ser-rous, C. Rosenfeld, and C. Denny, eds.), Elsevier, Amsterdam, pp. 31–39.

    Google Scholar 

  135. Fidler, I. J., 1973, Selection of successive tumor lines for metastasis, Nature New Biol. 242: 148–149.

    PubMed  CAS  Google Scholar 

  136. Nicolson, G. L., Museali, J. J., and McGuire, E. J., 1983, Metastatic RAW117 lymphosarcoma as a model for malignant-normal cell interaction. Possible roles for cell surface antigens in determining the quantity and localization of secondary tumors, Oncodev. BioMed. 4: 149–152.

    Google Scholar 

  137. Schirrmacher, V., Chiensong Popov, R., and Arnheiter, H., 1980, Hepatocyte tumor cell interactions in vitro, J. Exp. Med. 151: 984–989.

    Article  CAS  Google Scholar 

  138. Nicolson, G. L., Dulski, K. M., Basson, C., and Welch, D. R., 1985, Preferential organ attachment and invasion in vitro by B16 melanoma cells selected for different metastatic colonization and invasive properties, Invasion Metastasis 5: 144–158.

    PubMed  CAS  Google Scholar 

  139. Nicolson, G. L., Belloni, P. N., Tressler, R. J., Dulski, K., Inoue, T., and Cavanaugh, P. G., 1989, Adhesive, invasive and growth properties of selected metastatic variants of murine large cell lymphoma, Invasion Metastasis 9: 102–116.

    PubMed  CAS  Google Scholar 

  140. Kawaguchi, T., Kawaguchi, M., Miner, K. M., Lembo, T. M., and Nicolson, G. L., 1983, Brain meninges tumor formation by in vitro-selected metastatic B16 melanoma variants in mice, Clin. Exp. Metastasis 3: 247–259.

    Article  Google Scholar 

  141. Lapis, K., Pakus, S., and Liotta, L. A., 1988, Endothelialization of embolized tumor cells during metastasis formation, Clin. Exp. Metastasis 6: 73–89.

    Article  PubMed  CAS  Google Scholar 

  142. Netland, P.A., and Zetter, B. R., 1985, Metastatic potential of B16 melanoma cells after in vitro selection for organ-specific adherence, J. Cell Biol. 101: 720–724.

    Article  PubMed  CAS  Google Scholar 

  143. Menter, D. G., Hatfield, J. S., Harkins, C., Sloane, B. F., Taylor, J. D., Crissman, J. D., and Honn, K. V., 1987, Tumor cell-platelet interactions in vitro and their relationship to in vivo arrest of hematogenously circulating tumor cells, Clin. Exp. Metastasis 5: 65–78.

    Article  PubMed  CAS  Google Scholar 

  144. Kramer, R. H., and Nicolson, G. L., 1981, Invasion of vascular endothelial cells and underlying extracellular matrix by metastatic human cancer cells, in: International Cell Biology (S. Schweiger, ed.), Springer-Verlag, Berlin, pp. 794–799.

    Google Scholar 

  145. Varani, J., Orr, W., and Ward, P. A., 1980, Adhesion characteristics of tumor cell variants of high and low tumorigenic potential, J. Natl. Cancer Inst. 64: 1173–1178.

    PubMed  CAS  Google Scholar 

  146. Varani, J., Grimstad, I. A., Knibbs, R. N., Hovig, T., and McCoy, J. P., 1985, Attachment spreading, and growth in vitro of highly malignant and low malignant murine fibrosarcoma cells, Clin. Exp. Metastasis 3: 45–59.

    Article  PubMed  CAS  Google Scholar 

  147. Roos, E., Tulp, A., Middlekoop, O. P., and Pavert, I. V., 1985, Interaction between lymphoid tumor cells and isolated liver endothelial cells, J. Natl. Cancer Inst. 72: 1173–1180.

    Google Scholar 

  148. Korach, S., Poupon, M. F., Du Villard, J. A., and Becker, M., 1986, Differential adhesiveness of rhabdomyosarcoma-derived cloned metastatic cell lines to vascular endothelial monolayers, Cancer Res. 46: 3624–3629.

    PubMed  CAS  Google Scholar 

  149. Kramer, R. H., Gonzalez, R., and Nicolson, G. L., 1980, Metastatic tumor cells adhere preferentially to the extracellular matrix underlying vascular endothelial cells, Int. J. Cancer 26: 639–645.

    Article  PubMed  CAS  Google Scholar 

  150. Vlodavsky, I., Schirrmacher, V., Ariav, Y., and Fuks, Z., 1983, Lymphoma cell interaction with cultured vascular endothelial cells and with the subendothelial basal lamina: Attachment, invasion and morphological appearance, Invasion Metastasis 3: 81–97.

    PubMed  CAS  Google Scholar 

  151. Nicolson, G. L., Irimura, T., Gonzales, R., and Ruoslahti, E., 1981, The role of fibronectin in adhesion of metastatic melanoma cells to endothelial cells and their basal lamina, Exp. Cell Res. 135: 461–465.

    Article  PubMed  CAS  Google Scholar 

  152. Lichtner, R. B., Belloni, P. N., and Nicolson, G. L., 1989, Differential adhesion of metastatic rat mammary carcinoma cells to organ derived microvascular endothelial cells and subendothelial matrix, Exp. Cell Biol. 57: 146–152.

    PubMed  CAS  Google Scholar 

  153. Netland, P. A., and Zetter, B. R., 1986, Melanoma cell adhesion to defined extracellular matrix components, Biochem. Biophys. Res. Commun. 139: 515–522.

    Article  PubMed  CAS  Google Scholar 

  154. Murray, C. J., Liotta, L. A., Rennard, S. I., and Martin, G. R., 1980, Adhesion characteristics of murine metastatic and nonmetastatic tumor cells in vitro, Cancer Res. 40: 347–351.

    CAS  Google Scholar 

  155. Terranova, V. P., Williams, J. E., Liotta, L. A., and Martin, G. R., 1984, Modulation of metastatic activity of melanoma cells by laminin and fibronectin, Science 226: 982–985.

    Article  PubMed  CAS  Google Scholar 

  156. Chung, D. C., Zetter, B. R., and Brodt, N. P., 1988, Lewis lung carcinoma variants with different metastatic specificities adhere preferentially to differentially defined extracellular matrix molecules, Invasion Metastasis 8: 103–117.

    PubMed  CAS  Google Scholar 

  157. Liotta, L. A., Rao, C. N., and Barsky, S. H., 1983, Tumor invasion and the extracellular matrix, Lab. Invest. 49: 636–649.

    PubMed  CAS  Google Scholar 

  158. Irimura, T., Hester, J. E., Yamori, T., Belloni, P. N., Ota, D., and Nicolson, G. L., 1991, Preferential adhesion of metastatic human colon carcinoma cells and extracellular matrix, submitted for publication.

    Google Scholar 

  159. McCarthy, J. B., Basara, M. L., Palm, S. L., Sas, D. F., and Furcht, L. T., 1985, The role of cell adhesion proteins laminin and fibronectin in the movement of malignant and metastatic cells, Cancer Metastasis Rev. 4: 125–152.

    Article  PubMed  CAS  Google Scholar 

  160. Alby, L., and Auerbach, R., 1984, Differential adhesion of tumor cells to capillary endothelial cells in vitro, Proc. Natl. Acad. Sci. USA 81: 5739–5743.

    Article  CAS  Google Scholar 

  161. Belloni, P. N., Tressler, R. J., and Nicolson, G. L., 1991, Adhesion of metastatic tumor cells to organ-derived microvascular endothelial cells: Identification of non-integrin endothelial cell adhesion molecules, submitted for publication.

    Google Scholar 

  162. Yednock, T. A., and Rosen, S. D., 1989, Lymphocyte homing, Adv. Immunol. 44: 313–378.

    Article  PubMed  CAS  Google Scholar 

  163. Berg, E. L., Goldstein, L. A., Jutila, M. A., Nakache, M., Picker, L. J., Streeter, P. R., Wu, N. W., Zhou, D., and Butcher, E. C., 1989, Homing receptors and vascular addressins: Cell adhesion molecules that direct lymphocyte traffic, Immunol. Rev. 108: 5–18.

    Article  PubMed  CAS  Google Scholar 

  164. Belloni, P.N., and Nicolson, G. L., 1989, Identification and partial characterization of endothelial cell surface glycoproteins associated with adhesion of murine RAW117 large cell lymphoma cells and leukocytes. M. D. Anderson Symposium: Critical determinants in cancer progression and metastasis.

    Google Scholar 

  165. Bevilacqua, M. P., Stengelin, S., Gimbrone, M. A., and Seed, B., 1989, Endothelial leukocyte adhesion molecule 1: Receptor for neutrophils related to complement regulatory proteins and lectins, Science 243: 1160–1165.

    Article  PubMed  CAS  Google Scholar 

  166. Wood, N. L., Schook, L. B., Stoder, E. J., and Mohanakumar, T., 1988, Biochemical characterization of human vascular endothelial cell monolayer antigens defined by monoclonal antibodies, Transplantation 45: 787–792.

    Article  PubMed  CAS  Google Scholar 

  167. Butcher, E. C., and Weissman, I., 1984, Lymphocytes, tissues and organs, in: Fundamental Immunology (W. E. Paul, ed.), Raven Press, New York, pp. 109–127.

    Google Scholar 

  168. Bargatze, R. F., Wu, N. W., Weissman, I. L., and Butcher, E. C., 1987, High endothelial venule binding as a predictor of the dissemination of passaged murine lymphomas, J. Exp. Med. 166: 1125–1131.

    Article  PubMed  CAS  Google Scholar 

  169. Hatta, K. S., Takagi, S., Fujisawa, H., and Takeichi, M., 1987, Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryos, Dev. Biol. 120: 215–227.

    Article  PubMed  CAS  Google Scholar 

  170. Crossin, K. L., Chuong, C.M., and Edelman, G.M., 1985, Expression sequences of cell adhesion molecules, Proc. Natl. Acad. Sci. USA 82: 6942–6946.

    Article  PubMed  CAS  Google Scholar 

  171. Dustin, M. L., and Springer, T. A., 1988, Lymphocyte function associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells, J. Cell Biol. 107: 321–331.

    Article  PubMed  CAS  Google Scholar 

  172. Hynes, R. O., 1987, Integrins: A family of cell surface receptors, Cell 48: 549–554.

    Article  PubMed  CAS  Google Scholar 

  173. Ruoslahti, E., and Pierschbacher, M. D., 1987, New perspectives in cell adhesion, Science 238: 491–497.

    Article  PubMed  CAS  Google Scholar 

  174. Cheresh, D. A., Pytela, R., Pierschbacher, M. D., Klier, F. G., Ruoslahti, E., and Reisfeld, R. A., 1987, An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in a divalent cation-dependent functional complex with the disialoganglioside GD2, J. Cell Biol. 105: 1163–1173.

    Article  PubMed  CAS  Google Scholar 

  175. Miller, L. J., Schwarting, R., and Springer, T. A., 1986, Regulated expression of the Mac-1, LFA-1, pl50,95 glycoprotein family during leucocyte differentiation, J. Immunol. 137: 2891–2900.

    PubMed  CAS  Google Scholar 

  176. Springer, T. A., Dustin, M. L., Kishimoto, T. K., and Marlin, S. D., 1987, The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: Cell adhesion receptors of the immune system, Annu. Rev. Immunol. 5: 223–252.

    Article  PubMed  CAS  Google Scholar 

  177. Fitzgerald, L. A., Charo, I. F., and Phillips, D. R., 1985, Human and bovine endothelial cells synthesize membrane proteins similar to human platelet glycoproteins IIb and IIIa, J. Biol. Chem. 260: 10893–10896.

    PubMed  CAS  Google Scholar 

  178. Fujimoto, T., and Singer, S. J., 1988, Immunocytochemical studies of endothelial cells in vivo. H. Chicken aortic and capillary endothelial cells exhibit different cell surface distributions of the integrin complex, J. Histochem. Cytochem. 36: 1309–1317.

    Article  PubMed  CAS  Google Scholar 

  179. Knudsen, K. A., Smith, L., Smith, S., Karczewski, J., and Tuszynski, G. P., 1988, Role of IIb-IIIa-like glycoproteins in cell-substratum adhesion of human melanoma cells, J. Cell. Physiol. 136: 471–478.

    Article  PubMed  CAS  Google Scholar 

  180. McCarthy, J. B., Chelberg, M. K., Mickelson, D. J., and Furcht, L. T., 1988, Localization and chemical synthesis of fibronectin peptides with melanoma adhesion and heparin binding activities, Biochemistry 27: 1380–1388.

    Article  PubMed  CAS  Google Scholar 

  181. Humphries, M. J., Yamada, K. M., and Olden, K., 1988, Investigation of the biological effects of anti-cell adhesive synthetic peptides that inhibit experimental metastasis of B16–F10 murine melanoma cells, J. Clin. Invest. 81: 782–790.

    Article  PubMed  CAS  Google Scholar 

  182. Welch, D. R., Lobl, T. J., Seftor, E. A., Wack, P. I. J., Aeed, P. A., Rohem, K. H., Seftor, R. E. B., and Hendrix, M. J. C., 1989, Use of the membrane invasion culture system (MICS) as a screen for anti-invasive agents, Int. J. Cancer 43: 449–457.

    Article  PubMed  CAS  Google Scholar 

  183. Tressler, R. J., Belloni, P.N., and Nicolson, G. L., 1989, Correlation of inhibition of adhesion of large cell lymphoma and hepatic sinusoidal endothelial cells by RGD-containing peptide polymers with metastatic potential: Role of integrin-dependent and -independent adhesion mechanisms, Cancer Commun. 1: 55–63.

    PubMed  CAS  Google Scholar 

  184. Pierschbacher, M. D., and Ruoslahti, E., 1987, Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity of cell adhesion, J. Biol. Chem. 262: 17294–17298.

    PubMed  CAS  Google Scholar 

  185. Danilov, Y. N., and Juliano, R. L., 1989, (Arg-Gly-Asp)n-albumin conjugates as a model substratum for integrin-mediated cell adhesion, Exp. Cell Res. 182: 186–196.

    Article  PubMed  CAS  Google Scholar 

  186. Levin, J. M., and Garnier, J., 1988, Improvements in a secondary structure prediction method based on a search for local sequence homologies and its use as a model building tool, Biochim. Biophys. Acta 955: 283–295.

    Article  PubMed  CAS  Google Scholar 

  187. Iwamoto, F. A., Robey, J., Graf, M., Sasaki, S., Kleinman, H. K., Yamada, Y., and Martin, G. R., 1987, YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation, Science 238: 1132–1134.

    Article  PubMed  CAS  Google Scholar 

  188. Horak, E., Darling, D. L., and Tarin, D., 1986, Analysis of organ-specific effects on metastatic tumor formation by studies in vitro, J. Natl. Cancer Inst. 75: 913–922.

    Google Scholar 

  189. Naito, S., Giavazzi, R., and Fidler, I. J., 1987, Correlation between the in vitro interaction of tumor cells with an organ environmental and metastatic properties in vivo, Invasion Metastasis 7: 126–129.

    Google Scholar 

  190. Tsuruo, T., Kawabata, H., Iida, H., and Yamori, T., 1986, Tumor-induced platelet aggregation and growth promoting factors as determinants for successful tumor metastasis, Clin. Exp. Metastasis 4: 25–33.

    Article  PubMed  CAS  Google Scholar 

  191. Nicolson, G. L., and Dulski, K. M., 1986, Organ specificity of metastatic tumor colonization is related to organ-selective growth properties of malignant cells, Int. J. Cancer 38: 389–394.

    Article  Google Scholar 

  192. Nicolson, G. L., 1988, Differential organ tissue adhesion, invasion, and growth properties of metastatic rat mammary adenocarcinoma cells, Breast Cancer Res. Treat. 12: 167–176.

    Article  PubMed  CAS  Google Scholar 

  193. Nicolson, G. L., 1987, Differential growth properties of metastatic large cell lymphoma cells in target organ conditioned medium, Exp. Cell Res. 168: 572–577.

    Article  PubMed  CAS  Google Scholar 

  194. Holley, R. W., Bohlen, P., Fava, R., Baldwin, J. H., Kleeman, G., and Armour, R., 1980, Purification of kidney epithelial cell growth inhibitors, Proc. Natl. Acad. Sci. USA 77: 5989–5992.

    Article  PubMed  CAS  Google Scholar 

  195. Lücker, R. F., Shipley, G. D., Moses, H. L., and Holley, R. W., 1984, Growth inhibitor from BSC-1 cells closely related to platelet type b transforming growth factor, Science 226: 705–707.

    Article  Google Scholar 

  196. McMahon, J.B., Farelly, J. G., and Iype, P. T., 1982, Purification and properties of rat liver protein that specifically inhibits the proliferation of non-malignant epithelial cells from rat liver, Proc. Natl. Acad. Sci. USA 79: 456–460.

    Article  PubMed  CAS  Google Scholar 

  197. Szaniawska, B., Majewski, S., Kaminski, M. J., Noremberg, K., Swierz, M., and Janik, P., 1985, Stimulatory and inhibitory activities of lung-conditioned medium on the growth of normal and neoplastic cells in vitro, J. Natl. Cancer Inst. 75: 303–306.

    CAS  Google Scholar 

  198. Cavanaugh, P. G., and Nicolson, G. L., 1989, Purification and some properties of a lung-derived growth factor that differentially stimulates the growth of tumor cells metastatic to the lung, Cancer Res. 49: 3928–3933.

    PubMed  CAS  Google Scholar 

  199. Cavanaugh, P. G., and Nicolson, G. L., 1991, Lung-derived growth factor that stimulates the growth of lung-metastasizing tumor cells: identification as transferrin. J. Cell. Biochem. in press.

    Google Scholar 

  200. Yamori, T., Iida, H., Tsukagoshi, S., and Tsuruo, T., 1988, Growth stimulatory activity of lung extract on lung colonizing colon 26 clones and its partial characterization, Clin. Exp. Metastasis 6: 131–139.

    Article  PubMed  CAS  Google Scholar 

  201. Staunton, D. E., Dustin, M. L., and Springer, T. A., 1989, Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1, Nature 339: 61–64.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Tumor Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, 77030, USA

    Paula N. Belloni & Garth L. Nicolson

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Belloni, P.N., Nicolson, G.L. (1992). Role of the Vascular Endothelium in Cancer Metastasis. In: Simionescu, N., Simionescu, M. (eds) Endothelial Cell Dysfunctions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0721-9_24

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