Cellular and Molecular Mechanism of Glucose-Induced Diabetic Microangiopathy

  • Stuart K. Williams


The cellular and biochemical changes which occur as a result of diabetes mellitus all can be traced, albeit both directly and indirectly, to elevated blood glucose concentrations. The eventual cure of this disease will result from our understanding of insulin synthesis by the pancreatic beta cell. Until this time, treatments for the pathologic sequelae of diabetic hyperglycemia will continue to be a major effort in diabetes research.


Glomerular Basement Membrane Aldose Reductase Glomerular Endothelial Cell Hydrostatic Pressure Gradient Diabetic Angiopathy 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Stuart K. Williams
    • 1
  1. 1.Department of SurgeryUniversity of Arizona Health Sciences CenterTucsonUSA

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