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Mechanisms of Neutrophil Migration across Endothelium

  • Ada J. Huang
  • Samuel C. Silverstein

Abstract

Polymorphonuclear leukocytes (PMN) arise in the bone marrow and travel within the vascular compartment. Their final destination is in the extravascular tissues where they perform most of their effector functions. A critical and precisely regulated step in an inflammatory response is the movement of PMN across the endothelium. It is now clear that there are at least two distinct mechanisms by which PMN cross the endothelium in response to inflammatory stimuli, a PMN-initiated mechanism and an endothelial cell (EC)-initiated mechanism.

Keywords

Human Umbilical Vein Endothelial Cell Evans Blue Neutrophil Migration Endothelial Monolayer Human Umbilical Vein Endothelial Cell Monolayer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Ada J. Huang
    • 1
  • Samuel C. Silverstein
    • 2
  1. 1.Department of Medicine, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  2. 2.Department of Physiology and Cellular Biophysics, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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