Modulation of Endothelial Cell Proliferation by Monocyte-Derived Cytokines

  • J. L. Wautier
  • D. Vilette
  • J. P. Caen


Vascular endothelium, the cellular interface between blood and tissue, is a quiescent population of cells in vivo. Indeed, angiogenesis, the process of new blood vessel formation by endothelial cells, rare under normal physiological conditions. Labeling studies have shown that vascular endothelial cell turnover is low, 0.01 to 0.1% of the cells being labeled after a 24-hr [3H]thymidine pulse.1–3 However, during a few physiological settings, including wound healing or menstruation, angiogenesis does occur,4 but even during these processes, neovascularization is strongly regulated (i.e., is brief and strictly delimited). By contrast, uncontrolled angiogenesis is involved in serious diseases. For instance, vascularization is an absolute requirement for solid tumor growth,4,5 and in diabetic retinopathy, vascularization of the retina often leads to blindness.4


Endothelial Cell Human Umbilical Vein Endothelial Cell Familial Mediterranean Fever Thymidine Incorporation Endothelial Cell Proliferation 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • J. L. Wautier
    • 1
  • D. Vilette
    • 1
  • J. P. Caen
    • 1
  1. 1.Institut des Vaisseaux et du SangHôpital LariboisièreParisFrance

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