Abstract
Normal eukaryotic cells interact continuously and subtly with their surrounding milieu; variations in the nature, duration, and intensity of the extracellular stimuli generate a bidirectional interplay between the two. By virtue of their programmed genotype and the expressed metabolic, functional, and structural phenotype, cells are endowed with a finite capacity to adapt. In a homeostatic steady state, cells are able to handle normal physiologic demands. If the limits of their adaptive capacity are exceeded, as the result of excessive physiologic stimuli or pathologic stresses, the steady state can be altered. By their struggle to adapt, cells try to escape damage and premature death.
Keywords
- Endothelial Cell
- Endothelial Cell Injury
- Endothelial Cell Dysfunction
- Constitutive Function
- Irreversible Injury
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Andreoli, S. P., Mallett, C. P., and Bergstein, J. M., 1986, Role of glutathione in protecting endothelial cells against hydrogen peroxide oxidant injury, J. Lab. Clin. Invest. 108:190–198.
Block, E. R., Patel, J. M., Angelides, K. J., Sheridan, N. P., and Garg, L. C., 1986, Hyperoxia reduces plasma membrane fluidity: A mechanism for endothelial cell dysfunction, J. Appl. Physiol. 60:826–835.
Brandie, E. R., and Gabbiani, G., 1983, The role of cytoskeletal and cytocontractile elements in pathologic processes, Am. J. Pathol. 110:361–370.
Byron, M. A., Allington, M. J., Chapel, H. M., Mowat, A. G., and Cedarholm-Williams, S. A., 1987, Indications of vascular endothelial cell dysfunction in systemic lupus erythematosus, Ann. Rheum. Dis. 46:741–745.
Cavender, D. E., Edelbaum, D., and Ziff, M., 1989, Endothelial cell activation induced by tumor necrosis factor and lymphotoxin, Am. J. Pathol. 134:551–560.
Cotran, R. S., 1987. New roles for the endothelium in inflammation and immunity, Am. J. Pathol. 129: 407–413.
Cotran, R. S., and Pober, J. S., 1988, Endothelial activation: Its role in inflammatory and immune reactions, in: Endothelial Cell Biology in Health and Disease (N. Simionescu and M. Simionescu, eds.), Plenum Press, New York, pp. 335–347.
Cotran, R. S., Kumar, V., and Robbins, S. L. (eds.), 1989, Pathologic Basis of Disease, Saunders, Philadelphia, pp. 1–38.
Elices, M. J., Osborn, L., Takada, Y., Crouse, C., Luhovsky, S., Hemler, M. E., and Lobb, R. R., 1990, VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site, Cell 60:577–584.
Freeman, B. A., and Crape, J. D., 1982, Biology of disease: Free radicals and tissue injury, Lab. Invest. 47:412–420.
Gimbrone, M. A., Jr., 1989, Endothelial dysfunction and atherosclerosis, J. Cardiac Surg. 4:180–183.
Gimbrone, M. A., Jr., and Bevilacqua, M. P., 1988, Vascular endothelium: Functional modulation at the blood interface, in: Endothelial Cell Biology in Health and Disease (N. Simionescu and M. Simionescu, eds.), Plenum Press, New York, pp. 255–273.
Gordon, J. L., and Pearson, J. D., 1982, Responses of endothelial cells to injury, in: Pathobiology of the Endothelial Cell (H. L. Nossel and H. J. Vogel, eds.), Academic Press, New York, pp. 433–454.
Hajjar, K. A., Gavish, D., Breslow, J. L., and Nachman, R. L., 1989, Lipoprotein (a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis, Nature 339:303–305.
Halliwell, B., 1987, Oxidants and human disease: Some new concepts, FASEB J. 1:358–369.
Hennig, B., and Chow, C. K., 1988, Lipid peroxidation and endothelial cell injury: Implications in atherosclerosis, Free Radical Biol. Med. 4:99–106.
Henson, P. M., and Johnson, R. B., Jr., 1987, Tissue injury in inflammation: Oxidants, proteases and cationic proteins, J. Clin. Invest. 19:669–674.
Hirosumi, J., Ouchi, Y., Watanabe, M., Kusunoki, J., Nakamura, T., and Orimo, H., 1988, Effect of superoxide and lipid peroxide on cytosolic free calcium concentration in cultured pig aortic endothelial cells, Biochem. Biophys. Res. Commun. 152:301–307.
Hirschberg, H., 1981, Presentation of viral antigens by human vascular endothelial cells in vitro, Hum. Immunol. 2:235–246.
Jorgensen, L., Grothe, A. G., Larsen, T., Kinlough-Rathbone, R. L., and Mustard, J. F., 1986, Injury to cultured endothelial cells by thrombin-stimulated platelets, Lab. Invest. 54:408–415.
Joris, I., Zand, T., and Majno, G., 1982, Hydrodynamic injury of the endothelium in acute aortic stenosis, Am. J. Pathol. 106:394–408.
Jutila, M. A., Berg, E. L., Kishimoto, T. K., Picker, L. J., Bargatze, R. F., Bisho, D. K., Orosz, C. G., Wu, N. W., and Butcher, E. C., 1989, Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils and monocytes, Transplantation 48:727–731.
Lindquist, S., 1986, The heat shock response, Annu. Rev. Biochem. 55:1151–1191.
Majno, G., 1975, The Healing Hand: Man and Wound in the Ancient World, Harvard University Press, Cambridge, Mass., p. 43.
Majno, G., Zand, T., Nunnari, J. J., Kowala, M. C., and Joris, J., 1988, Intimai response to shear stress, hypercholesterolemia and hypertension: Studies in the rat aorta, in: Endothelial Cell Biology in Health and Disease (N. Simionescu and M. Simionescu, eds.), Plenum Press, New York, pp. 349–367.
Nag, S., 1986, Cerebral endothelial plasma membrane alterations in acute hypertension, Acta Neuropathol. 70:38–43.
Pederson, D. C., and Bowyer, D. E., 1985, Endothelial injury and healing in vitro. Studies using an organ culture system, Am. J. Pathol. 119:264–272.
Poumay, Y., and Ronveau-Dupal, M. F., 1988, Incubation of endothelial cells in a superoxide-generating system: Impaired low density lipoprotein receptor-mediated endocytosis, J. Cell. Physiol. 136:289–296.
Reidy, M. A., 1985, A reassessment of endothelial injury and arterial lesion formation, Lab. Invest. 53: 513–526.
Roberts, J. M., Taylor, R. N., Musci, T. J., Rodgers, J. M., Hubel, C. A., and McLaughlin, M. K., 1989, Preeclampsia: An endothelial cell disorder, Am. J. Obstet. Gynecol. 161:1200–1204.
Ryan, U. S., 1987, Endothelial cell activation responses, in: Pulmonary Endothelium in Health and Disease (U. S. Ryan, ed.), Dekker, New York, pp. 3–33.
Sasaguri, Y., Morimatsu, M., Kinoshita, T., Nakashima, T., Inagaki, T., and Yagi T., 1985, Difference in susceptibility to injury by linoleic acid hydroperoxide between endothelial and smooth muscle cells of arteries, J. Appl. Biochem. 7:70–78.
Simionescu, N., 1988, Prelesional changes of arterial endothelium in hyperlipoproteinemic atherogenesis, in: Endothelial Cell Biology in Health and Disease (N. Simionescu and M. Simionescu, eds.), Plenum Press, New York, pp. 385–429.
Simionescu, N., Vasile, E., Lupu, F., Popescu, G., and Simionescu, M., 1986, Prelesional events in atherogenesis: Accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit, Am. J. Pathol. 123:109–125.
Slater, T. F., 1984, Free radical mechanisms in tissue injury, Biochem. J. 222:1–4.
Starkebaum, G., and Harlan, J. M., 1986, Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine, J. Clin. Invest. 77:1370–1376.
Walker, L. N., and Bowyer, D. E., 1984, Endothelial healing in rabbit aorta and the effect of risk factors for atherosclerosis: Hypercholesterolemia, Arteriosclerosis 4:479–488.
Wallis, W. J., and Harlan, J. M., 1986, Effector functions of endothelium in inflammatory and immunologic reactions, Pathol. Immunopathol. Res. 5:73–103.
Warren, J. S., and Ward, P. A., 1986, Review: Oxidative injury to the vascular endothelium, Am. J. Med. Sci. 292:97–103.
Werns, S. W., Walton, J. A., Hsia, H. H., Nabel, E. G., Sanz, M. L., and Pitt, B., 1989, Evidence of endothelial dysfunction in angiographically normal coronary arteries of patients with coronary disease, Circulation 79:287–291.
Zand, T., Nunnari, J. J., Hofman, A. H., Savilonis, B. J., MacWilliams, B., Majno, G., and Joris, I., 1988, Endothelial adaptations in aortic stenosis. Correlation with flow parameters, Am J. Pathol. 133:407–418.
Zoja, C., Furci, L., Ghilardi, F., Zilio, P., Benigni, A., and Remuzzi, G., 1986, Cyclosporin-induced endothelial cell injury, Lab. Invest. 55:455–462.
Zweier, J. L., Kuppusami, P., and Lutty, G. A., 1988, Measurement of endothelial cell free radical generation: Evidence for a central mechanism of free radical injury in postischemic tissues, Proc. Natl. Acad. Sci. USA 85:4046–4050.
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Simionescu, M. (1992). Endothelial Cell Response to Normal and Abnormal Stimuli. In: Simionescu, N., Simionescu, M. (eds) Endothelial Cell Dysfunctions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0721-9_1
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DOI: https://doi.org/10.1007/978-1-4899-0721-9_1
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