Endothelial Cell Response to Normal and Abnormal Stimuli

Modulation, Dysfunction, Injury; Adaptation, Repair, Death
  • Maya Simionescu


Normal eukaryotic cells interact continuously and subtly with their surrounding milieu; variations in the nature, duration, and intensity of the extracellular stimuli generate a bidirectional interplay between the two. By virtue of their programmed genotype and the expressed metabolic, functional, and structural phenotype, cells are endowed with a finite capacity to adapt. In a homeostatic steady state, cells are able to handle normal physiologic demands. If the limits of their adaptive capacity are exceeded, as the result of excessive physiologic stimuli or pathologic stresses, the steady state can be altered. By their struggle to adapt, cells try to escape damage and premature death.


Endothelial Cell Endothelial Cell Injury Endothelial Cell Dysfunction Constitutive Function Irreversible Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Maya Simionescu
    • 1
  1. 1.Institute of Cellular Biology and PathologyBucharestRomania

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