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The Use of Pharmacology in the Treatment of Head-Injured Patients

  • Leslie K. Ross
Part of the Critical Issues in Neuropsychology book series (CINP)

Abstract

It is common for cognitive, emotional, and behavioral deficits to occur following head injury. However, research reveals that head-injured individuals are more seriously handicapped by emotional and associated behavioral disturbances (e.g., agitation) than by residual cognitive or physical disabilities (Lezak, 1987). These emotional disturbances may impede their overall recovery from the head trauma (Dikeman & Reitan, 1977; Jackson, Corrigan, & Arnett, 1985; Levin, Grossman, Rose, & Teasdale, 1979; Lishman, 1973; Prigatano, 1986; Stern, 1978; Thomsen, 1984). A frequently exhibited problem in up to 33% of patients recovering from significant head-injury is agitation, characterized by cognitive disorganization, interpersonal isolation, combativeness, and affective disturbance (Jackson et al., 1985). Additionally, 67% of patients post-head injury experience anxiety, regressive manifestations, and frontal lobe syndromes (e.g., flattened affect, apathy, loss of inhibitions, disturbance in judgement) (Lishman, 1973; Stern, Najenson, Grosswasser, Mendelson, & Davidson, 1976). Also, emotional and behavioral disturbances are not limited to moderately and severely impaired patients. Patients attaining good cognitive recovery often exhibit significant anxiety and depression as well. It is not uncommon for emotional and behavioral impairments to develop into significant psychiatric disorders of psychotic proportions that can require inpatient treatment.

Keywords

Traumatic Brain Injury Head Injury Disruptive Behavior Behavioral Disturbance Medroxyprogesterone Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adamovich, B. B., Henderson, J. A., & Auerbach, S. (1985). Cognitive rehabilitation of closed head injured patients: A dynamic approach. San Diego: College-Hill.Google Scholar
  2. Alpers, B. J. (1937). Relation of the hypothalamus to disorders of personality. Archives of Neurology & Psychiatry, 38, 291–303.CrossRefGoogle Scholar
  3. Annegers, J., Grabow, J., Kurtland, L., & Laws, E. (1980). The incidence, causes, and secular trends of head trauma in Olmstead County, Minnesota. Neurology, 30, 912–919.PubMedCrossRefGoogle Scholar
  4. Arnold, L. E., Strobl, D., & Weisenberg, A. (1972). Hyperkinetic adult: Study of the “paradoxical” amphetamine response. Journal of the American Medical Association, 222, 693–694.PubMedCrossRefGoogle Scholar
  5. Bevan, P, Bradshaw, C. M., & Szabadi, E. (1975). Effects of desipramine on neuronal responses to dopamine, noradrenaline, 5-hydroxytryptamine and acetylcholine in the caudate nucleus of the rat. British Journal of Pharmacology, 54, 285–293.PubMedCrossRefGoogle Scholar
  6. Blumer, D., & Benson, D. (1975). Personality changes with frontal and temporal lobe lesions. In D. Benson & D. Blumer (Eds.), Psychiatric aspects of neurologic disease (pp. 151–170). New York: Grune & Stratton.Google Scholar
  7. Blumer, D., & Migeon, C. (1975). Hormone and hormonal agents in the treatment of aggression. Journal of Nervous & Mental Disease, 160, 127–137.CrossRefGoogle Scholar
  8. Bouvy, P. F., van de Wetering, B. J. M., Meerwaldt, J. D., & Bruijn, J. B. (1988). A case of organic brain syndrome following head injury successfully treated with carbamazepine. Acta Psychiatrica Scandinavica, 77, 361–363.PubMedCrossRefGoogle Scholar
  9. Brailowsky, S. (1980). Neuropharmacological aspects of brain plasticity. In P. Bach-y-Rita (Ed.), Recovery of function: Theoretical considerations for brain injury rehabilitation (pp. 187–224). Baltimore: University Park Press.Google Scholar
  10. Bray, L. J., Carlson, F., Humphrey, R., Mastrilli, J. P, & Valko, A. S. (1987). Physical rehabilitation. In M. Ylvisaker & E. M. R. Gobble (Eds.), Community re-entry for head injured adults (pp. 25–86). Boston: Little, Brown.Google Scholar
  11. Brogden, R. N., Heel, R. C., Speight, T. M., & Avery, G. S. (1981). Trazodone: A review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs, 21, 401–429.PubMedCrossRefGoogle Scholar
  12. Brooks, N., Campsie, L., Symington, C., Beattie, A., & McKinlay, W. (1986). The five year outcome of severe blunt head injury: A relative’s view. Journal of Neurology, Neurosurgery, & Psychiatry, 49, 164–110.Google Scholar
  13. Brooks, N., Campsie, L., Symington, C., Beattie, A., & McKinlay, W. (1987). The effects of severe head injury on patient and relative within seven years of injury. Journal of Head Trauma Rehabilitation, 2, 1–13.CrossRefGoogle Scholar
  14. Cooper, J. R., Bloom, F. E., & Roth, R. H. (1982). The biochemical basis of neuropharmacology (4th ed.). New York: Oxford University Press.Google Scholar
  15. Cooper, S. J. (1984). Drug treatments, neurochemical change and human memory impairment. In B. A. Wilson & N. Moffat Eds., Clinical management of memory problems. Rockville: Aspen Publications.Google Scholar
  16. Cope, D. N. (1986). The pharmacology of attention and memory. Journal of Head Trauma Rehabilitation, 1, 34–42.CrossRefGoogle Scholar
  17. Cope, D. N. (1987a). Psychopharmacologic considerations in the treatment of traumatic brain injury. Journal of Head Trauma Rehabilitation, 2, 1–5.CrossRefGoogle Scholar
  18. Cope, D. N. (1987b). Psychopharmacology [Special issue]. Journal of Head Trauma Rehabilitation, 2(4).Google Scholar
  19. Cummings, J. L., & Mendez, M. F. (1984). Secondary mania with focal cerebrovascular lesions. American Journal of Psychiatry, 141, 1084–1087.PubMedGoogle Scholar
  20. Dikeman, S., & Reitan, R. M. (1977). Emotional sequelae of head injury. Annals of Neurology, 2, 429–494.Google Scholar
  21. Elliot, F. A. (1976). The neurology of explosive rage: The dyscontrol syndrome. The Practitioner, 217, 51–60.Google Scholar
  22. Elliot, F. A. (1977). Propranolol for the control of belligerent behavior following acute brain damage. Annals of Neurology, 1, 489–491.CrossRefGoogle Scholar
  23. Evans, R. W., & Gualtieri, C. T. (1985). Carbamazepine: A neuropsychological and psychiatric profile. Clinical Neuropharmacology, 8, 221–241.PubMedCrossRefGoogle Scholar
  24. Evans, R. W., Gualtieri, C. T., & Patterson, D. (1987). Treatment of chronic closed head injury with psycho stimulant drugs: A controlled case study and an appropriate evaluation procedure. Journal of Nervous & Mental Disease, 175, 106–110.CrossRefGoogle Scholar
  25. Feeney, D. M., Gonzalez, A., & Law, W. A. (1982). Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury. Science, 217, 855–857.PubMedCrossRefGoogle Scholar
  26. Feeney, D. M., Sutton, R. L., Boyeson, M. G., Hovda, D. A., & Dail, W. G. (1985). The locus coeruleus and cerebral metabolism: Recovery of function after cortical injury. Physiologic Psychology, 13, 197–203.Google Scholar
  27. Finger, S., & Stein, D. G. (1982). Brain damage and recovery: Research and clinical perspectives. New York: Academic Press.Google Scholar
  28. Fordyce, D. J., Roueche, J. R., & Prigatano, G. P. (1983). Enhanced emotional reactions in chronic head trauma patients. Journal of Neurology, Neurosurgery, & Psychiatry, 46, 620–624.CrossRefGoogle Scholar
  29. Gardos, G. (1980). Disinhibition of behavior by antianxiety drugs. Psychosomatics, 21, 1025–1026.PubMedGoogle Scholar
  30. Gelenberg, A. J. (1983). Psychoses. In E. L. Bassuk, S. C. Schoonover, & A. J. Gelenberg (Eds.), The practitioner’s guide to psychoactive drugs (2nd ed.) (pp. 115–165). New York: Plenum Press.CrossRefGoogle Scholar
  31. Geyer, M. A., Puerto, A., Menkes, D. B., Segal, D. S., & Mandell, A. J. (1976). Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways. Brain Research, 106, 257–270.PubMedCrossRefGoogle Scholar
  32. Glenn, M. B. (1987a). A pharmacologic approach to aggressive and disruptive behaviors after traumatic brain injury (Part 1). Journal of Head Trauma Rehabilitation, 2, 11–13.CrossRefGoogle Scholar
  33. Glenn, M. B. (1987b). A pharmacologic approach to aggressive and disruptive behaviors after traumatic brain injury (Part 3). Journal of Head Trauma Rehabilitation, 2, 85–87.CrossRefGoogle Scholar
  34. Glenn, M. B. (1987c). Chronic hypertension after traumatic brain injury: Pharmacologie options. Journal of Head Trauma Rehabilitation, 2, 71–73.CrossRefGoogle Scholar
  35. Glenn, M. B., & Joseph, A. B. (1987). The use of lithium for behavioral and affective disorder after traumatic brain injury. Journal of Head Trauma Rehabilitation, 2, 68–76.CrossRefGoogle Scholar
  36. Glick, S. D., & Zimmerberg, B. (1978). Pharmacological modification of brain lesion syndromes. In S. Finger (Ed.), Recovery from brain damage: Research and theory (pp. 281–296). New York: Plenum Press.CrossRefGoogle Scholar
  37. Greendyke, R. M., & Kanter, D. R. (1986). Therapeutic effects of pindolol on behavioral disturbances associated with organic brain disease: A double-blind study. Journal of Clinical Psychiatry, 47, 423–426.PubMedGoogle Scholar
  38. Griffith, E. R. (1983). Spasticity. In M. Rosenthal, E. R. Griffith, M. R. Bond, & J. D. Miller, (Eds.), Rehabilitation of the head injured adult (pp. 125–141). Philadelphia: Davis.Google Scholar
  39. Haas, J. F, & Cope, D. N. (1985). Neuropharmacologic management of behavioral sequelae in head injury: A case report. Archives of Physical Medicine & Rehabilitation, 66, 472–474.Google Scholar
  40. Hale, M. S., & Donaldson, J. O. (1982). Lithium carbonate in the treatment of organic brain syndrome. Journal of Nervous & Mental Disease, 170, 362–365.CrossRefGoogle Scholar
  41. Hayden, M. E., & Hart, T. (1986). Rehabilitation of cognitive and behavioral dysfunction in head injury. Advances in Psychosomatic Medicine, 16, 194–229.PubMedGoogle Scholar
  42. Healey, M., Pickens, R., Meisch, R., & McKenna, T. (1983). Effects of clorazepate, diazepam, lorazepam, and placebo on human memory. Journal of Clinical Psychiatry, 44, 436–439.PubMedGoogle Scholar
  43. Higashi, K., Sakata, Y, Hatano, M., Abiko, S., Ihara, K., Katayama, S., Wakuta, Y, Okamura, T, Ueda, H., Zenke, M., & Aoki, H. (1977). Epidemiological studies on patients with a persistent vegetative state. Journal of Neurology, Neurosurgery, & Psychiatry, 40, 876–885.CrossRefGoogle Scholar
  44. Jabbari, B., Bryan, G. E., Marsh, E. E., & Gunderson, C. (1985). Incidence of seizures with tricyclic and tetracyclic antidepressants. Archives of Neurology, 42, 480–481.PubMedCrossRefGoogle Scholar
  45. Jackson, R. D., & Mysiw, W. J. (1989). Abnormal cortisol dynamics after traumatic brain injury: Lack of utility in predicting agitation or therapeutic response to tricyclic antidepressants. American Journal of Physical Medicine & Rehabilitation, 68, 18–23.CrossRefGoogle Scholar
  46. Jackson, R. D., Corrigan, J. D., & Arnett, J. A. (1985). Amitriptyline for agitation in head injury. Archives of Physical Medicine & Rehabilitation, 66, 180–181.Google Scholar
  47. Jacobs, B. L., Trimbach, C., Eubanks, E. E., & Trulson, M. (1975). Hippocampal mediation of raphe lesion-and PCPA-induced hyperactivity in the rat. Brain Research, 94, 253–261.PubMedCrossRefGoogle Scholar
  48. Joshi, P, Capozzoli, J. A., & Coyle, J. T. (1985). Effective management with lithium of a persistent post-traumatic hypomania in a 10-year-old child. Developmental and Behavioral Pediatrics, 6, 352–354.CrossRefGoogle Scholar
  49. Karol, R. L. (1989). The duration of seeking help following traumatic brain injury: The persistence of nonneurological symptoms. The Clinical Neuropsychologist, 3, 244–249.CrossRefGoogle Scholar
  50. Kleindienst-Venderbeke, G. (1984). Informational processing and benzodiazepines. Neuropsychobiology, 12, 238–243.CrossRefGoogle Scholar
  51. Kosteljanetz, M., Jensen, T. S., Nrgard, B., Lunde, I., Jensen, P B., & Johnsen, S. G. (1981). Sexual and hypothalamic dysfunction in the postconcussional syndrome. Acta Neurologica Scandinavica, 63, 169–180.PubMedCrossRefGoogle Scholar
  52. Krauthammer, C., & Klerman, G. L. (1978). Secondary mania. Archives of General Psychiatry, 35, 1333–1339.PubMedCrossRefGoogle Scholar
  53. Lawson, I. R., & MacLeod, R. D. M. (1969). The use of imipramine (“Tofranil”) and other psychotropic drugs in organic emotionalism. British Journal of Psychiatry, 115, 281–285.PubMedCrossRefGoogle Scholar
  54. Lehne, G. K. (1984–1986). Brain damage and paraphilia: Treated with medroxyprogesterone acetate. Sexuality & Disability, 7, 145–158.CrossRefGoogle Scholar
  55. Levin, H. S., & Grossman, R. G. (1978). Behavioral sequelae of closed head injury: A quantitative study. Archives of Neurology, 35, 720–727.PubMedCrossRefGoogle Scholar
  56. Levin, H. S., Grossman, R. G., Rose, J. E., & Teasdale, G. (1979). Long-term neuropsychological outcome of closed head injury. Journal of Neurosurgery, 50, 412–422.PubMedCrossRefGoogle Scholar
  57. Levin, H. S., Handel, S. F., Goldman, A. M., Eisenberg, H., & Guinto, F. C. (1985). Magnetic resonance imaging after diffuse nonmissile head injury—A neurobehavioral study. Archives of Neurology, 42, 963–968.PubMedCrossRefGoogle Scholar
  58. Lezak, M. D. (1987). Relationships between personality disorders, social disturbances, and physical disability following traumatic brain injury. Journal of Head Trauma Rehabilitation, 2,57–69.CrossRefGoogle Scholar
  59. Lipper, S., & Tuchman, M. M. (1976). Treatment of chronic posttraumatic organic brain syndrome with dextroamphetamine: First reported case. Journal of Nervous & Mental Disease, 162, 366–371.CrossRefGoogle Scholar
  60. Lipsey, J. R., Robinson, R. G., Pearlson, G. D., Rao, K., & Price, T. R. (1984). Nortriptyline treatment of poststroke depression: A double-blind treatment trial. Lancet, 1, 297–300.PubMedCrossRefGoogle Scholar
  61. Lishman, W. A. (1973). The psychiatric sequelae of head injury: A review. Psychological Medicine, 3, 304–318.PubMedCrossRefGoogle Scholar
  62. Livingston, K. E., & Escobar, A. (1972). The continuing evolution of the limbic system concept. In E. Hitchcock, L. Laitinen, & K. Vaernet (Eds.), Psychosurgery (pp. 25–33). Springfield, IL: Thomas.Google Scholar
  63. Livingston, K. E., & Escobar, A. (1973). Tentative limbic system models for certain patterns of psychiatric disorders. In L. V. Laitinen & K. E. Livingston (Eds.), Surgical approaches in psychiatry (pp. 245–252). Lancaster, Great Britain: Medical & Technical Publishing.Google Scholar
  64. Luria, A. R., Naydin, V. L., Tsvetkova, L. S., & Vinarskaya, E. N. (1969). Restoration of higher cortical function following local brain damage. In P. J. Vinken & G. W. Bruyn (Eds.), Disorders of higher nervous activity (Vol. 3, pp. 368–433). New York: American Elsevier.Google Scholar
  65. Lyeth, B. G., Dixon, C. E., Jenkins, L. W., Hamm, R. J., Alberico, A., Young, H. F., Stonnington, H. H., & Hayes, R. L. (1988). Effects of scopolamine treatment on long-term behavioral deficits following concussive brain injury to the rat. Brain Research, 452, 39–48.PubMedCrossRefGoogle Scholar
  66. McKinlay, W. W., Brooks, D. N., Bond, M. R., Martinage, D. R., & Marshall, M. M. (1981). The short-term outcome of severe blunt head injury as reported by relatives of the injured persons. Journal of Neurology, Neurosurgery, & Psychiatry, 44, 527–533.CrossRefGoogle Scholar
  67. Mann, H. B., & Greenspan, S. I. (1976). The identification and treatment of adult brain dysfunction. American Journal of Psychiatry, 133, 1013–1017.PubMedGoogle Scholar
  68. Mattes, J. A. (1986). Psychopharmacology of temper outbursts: A review. Journal of Nervous & Mental Disease, 174, 464–470.CrossRefGoogle Scholar
  69. Meyer, D. R., & Meyer, P. M. (1977). Dynamics and bases of recoveries of functions after injuries to the cerebral cortex. Physiological Psychology, 5, 133–165.Google Scholar
  70. Meyer, J. E. (1955). Die sexuellen Storungen der hirnverletzten. Archives of Psychiatry,199, 449.CrossRefGoogle Scholar
  71. Miller, E. (1984). Recovery and management of neuropsychological impairments. New York: Wiley.Google Scholar
  72. Morrison, J. H., Molliver, M. E., & Grzanna, R. (1979). Noradrenergic innervation of cerebral cortex: Widespread effects of local cortical lesions. Science, 20, 313–316.CrossRefGoogle Scholar
  73. Muir, C. A., Haffey, W. J., Ott, K. J., Karaica, D, Muir, J. H., & Sutko, M. (1983). Treatment of behavioral deficits. In M. Rosenthal, E. R. Griffith, M. R. Bond, & J. D. Miller (Eds.), Rehabilitation of the head injured adult (pp. 381–393). Philadelphia: Davis.Google Scholar
  74. Mysiw, W. I., & Jackson, R. D. (1987). Tricyclic antidepressant therapy after traumatic brain injury. Journal of Head Trauma Rehabilitation, 2, 34–42.CrossRefGoogle Scholar
  75. Mysiw, W. J., Jackson, R. D., & Corrigan, J. D. (1988). Amitriptyline for post-traumatic agitation. American Journal of Physical Medicine & Rehabilitation, 67, 29–33.CrossRefGoogle Scholar
  76. Nair, N. P. V., Ban, T. A., Hontela, S., & Clarke, M. A. (1973). Trazodone in the treatment of organic brain syndromes, with special reference to psychogeriatrics. Current Therapeutic Research, 15, 169–115.Google Scholar
  77. Olds, J. (1958). Self-stimulation of the brain. Science, 127, 315–324.PubMedCrossRefGoogle Scholar
  78. O’Shanick, G. J. (1986). Neuropsychiatrie complications in head injury. Advances in Psychosomatic Medicine, 16, 173–193.PubMedGoogle Scholar
  79. O’Shanick, G. J. (1987). Clinical aspects of psychopharmacologic treatment in head-injured patients. Journal of Head Trauma Rehabilitation, 2, 59–67.CrossRefGoogle Scholar
  80. Pearlson, G., & Robinson, R. (1981). Suction lesions of the frontal cerebral cortex in the rat induce symmetrical behavioral and catecholaminergic responses. Brain Research, 218, 233–242.PubMedCrossRefGoogle Scholar
  81. Peterson, L. (1986). Acute response to trauma. Advances in Psychosomatic Medicine, 16, 84–92.PubMedGoogle Scholar
  82. Peterson, L., & O’Shanick, G. (1985). Endocrine diseases presenting with psychiatric symptoms. Postgraduate Medicine, 77, 233–239.PubMedGoogle Scholar
  83. Pomara, N., Deptula, D., Medel, M., Block, R. I., & Greenblatt, D. J. (1989). Effects of diazepam on recall memory: Relationship to aging, dose, and duration of treatment. Psychopharmacology Bulletin, 25, 144–148.PubMedGoogle Scholar
  84. Pope, H. G., McElroy, S. L., Satlin, A., Hudson, J. I., Keck, P E., Jr., & Kalish, R. (1988). Head injury, bipolar disorder, and response to valproate. Comprehensive Psychiatry, 29, 34–38.PubMedCrossRefGoogle Scholar
  85. Prigatano, G. P. (1986). Personality and psychosocial consequences of brain injury. In G. P. Prigatano, D. J. Fordyce, H. K. Zeiner, J. R. Roueche, M. Pepping, & B. C. Wood (Eds.), Neuropsychological rehabilitation after brain injury (pp. 29–50). Baltimore: Johns Hopkins University Press.Google Scholar
  86. Prigatano, G. P. (1987). Recovery and cognitive retraining after craniocerebral trauma. Journal of Learning Disabilities, 20, 603–613.PubMedCrossRefGoogle Scholar
  87. Rao, N., Jellinek, H. M., & Woolston, D. C. (1985). Agitation in closed head injury: Haloperidol effects on rehabilitation outcome. Archives of Physical Medicine Rehabilitation, 66, 30–34.Google Scholar
  88. Reding, M. J., Orto, L. A., Winter, S. W, Fortuna, I. M., Di Ponte, P., & McDowell, F H. (1986). Antidepressant therapy after stroke: A double blind trial. Archives of Neurology, 43, 763–765.PubMedCrossRefGoogle Scholar
  89. Reisberg, B., Ferris, S. H., & Gershon, S. (1981). An overview of pharmacologic treatment of cognitive decline in the aged. American Journal of Psychiatry, 138, 593–600.PubMedGoogle Scholar
  90. Richmond, J. S., Young, J. R., & Groves, J. E. (1978). Violent dyscontrol responsive to d-amphetamine. American Journal of Psychiatry, 135, 365–366.PubMedGoogle Scholar
  91. Robinson, R. (1979). Differential behavioral and biochemical effects of right and left hemispheric cerebral infarction in the rat. Science, 205, 707–710.PubMedCrossRefGoogle Scholar
  92. Ross, E. D., & Rush, A. J. (1981). Diagnosis and neuroanatomical correlates of depression in brain-damaged patients. Archives of General Psychiatry, 38, 1344–1354.PubMedCrossRefGoogle Scholar
  93. Saran, A. S. (1985). Depression after minor closed head injury: Role of dexamethasone suppression test and antidepressants. Journal of Clinical Psychiatry, 46, 335–338.PubMedGoogle Scholar
  94. Saran, A. S. (1988). Antidepressants not effective in headache associated with minor closed head injury. International Journal of Psychiatry in Medicine, 18, 75–83.PubMedCrossRefGoogle Scholar
  95. Schiffer, R. B., Cash, J., & Herndon, R. M. (1983). Treatment of emotional lability with low-dosage tricyclic antidepressants. Psychosomatics, 24, 1094–1096.PubMedCrossRefGoogle Scholar
  96. Schiffer, R. B., Herndon, R. M., & Rudick, R. A. (1985). Treatment of pathologic laughing and weeping with amitriptyline. The New England Journal of Medicine, 312,1480–1482.PubMedCrossRefGoogle Scholar
  97. Schneider, S. K., & Kaplan, S. M. (1989). Secondary mania resulting from a closed-head injury. The Clinical Neuropsychologist, 3,230–234.CrossRefGoogle Scholar
  98. Simpson, D. M., & Foster, D. (1986). Improvement in organically disturbed behavior with trazodone treatment. Journal of Clinical Psychiatry, 47, 191–193.PubMedGoogle Scholar
  99. Stern, J. M. (1978). Cranio-cerebral injured patients. Scandinavian Journal of Rehabilitation Medicine,10, 7.PubMedGoogle Scholar
  100. Stern, J. M., Najenson, T., Grosswasser, Z., Mendelson, L., & Davidson, S. (1976). Psychiatric aspects of the rehabilitation of the severely brain injured. Israel Annals of Psychiatry & Related Disciplines, 14,333–344.Google Scholar
  101. Stewart, J. T, & Hemsath, R. H. (1988). Bipolar illness following traumatic brain injury: Treatment with lithium and carbamazepine. Journal of Clinical Psychiatry, 49, 74–75.PubMedGoogle Scholar
  102. Sundet, K., Finset, A., & Reinvang, I. (1988). Neuropsychological predictors in stroke rehabilitation. Journal of Experimental Neuropsychology, 10, 363–379.CrossRefGoogle Scholar
  103. Sutton, R. L., Weaver, W. S., & Feeney, D. M. (1987). Drug-induced modification of behavioral recovery following cortical trauma. Journal of Head Trauma Rehabilitation, 2, 50–58.CrossRefGoogle Scholar
  104. Thomsen, I. V (1984). Late outcome of very severe blunt head trauma: A 10–15 year second follow-up. Journal of Neurology, Neurosurgery, & Psychiatry, 47, 260–268.CrossRefGoogle Scholar
  105. Trimble, M. R., & Thompson, P J. (1983). Anticonvulsant drugs and cognitive function and behavior. Epilepsia, 24(Suppl. 1), 555–563.Google Scholar
  106. Tune, L. E., Damlouji, N. F., Holland, A., Gardner, T. J., Folstein, M. F., & Coyle, J. T. (1981). Association of postoperative delirium with raised serum levels of anticholinergic drugs. Lancet, 2, 651–652.PubMedCrossRefGoogle Scholar
  107. Tyler, G. S., McNeely, H. E., & Dick, M. L. (1980). Treatment of post-traumatic headache with amitriptyline. Headache, 20, 213–216.PubMedCrossRefGoogle Scholar
  108. Udaka, F., Yamao, S., Nagata, H., Nakamura, S., & Kameyama, M. (1984). Pathologic laughing and crying treated with levodopa. Archives of Neurology, 41, 1095–1096.PubMedCrossRefGoogle Scholar
  109. van Woerkom, T. C. A. M., Teelken, A. W., & Minderhoud, J. M. (1977). Difference in neurotransmitter metabolism in frontotemporal-lobe contusion and diffuse cerebral contusion. Lancet, 1, 812–813.PubMedCrossRefGoogle Scholar
  110. Vogel, J. R. (1979). Objective measurement of human performance changes produced by antianxiety drugs. In S. Fielding & H. Lal (Eds.), Anxiolytics (pp. 343–374). Mount Kisco, NY: Futura Publishing.Google Scholar
  111. Weinberg, R. M., Auerbach, S. H., & Moore, S. (1987). Pharmacologic treatment of cognitive deficits: A case study. Brain Injury, 1, 57–59.PubMedCrossRefGoogle Scholar
  112. Weinstein, G. S., & Wells, C. E. (1981). Case studies in neuropsychiatry: Post-traumatic psychiatric dysfunction—diagnosis and treatment. Journal of Clinical Psychiatry, 42, 120–122.PubMedGoogle Scholar
  113. Whyte, J., & Glenn, M. B. (1986). The care and rehabilitation of the patient in a persistent vegetative state. Head Trauma Rehabilitation, 1, 39–53.CrossRefGoogle Scholar
  114. Williams, K. H., & Goldstein, G. (1979). Cognitive and affective responses to lithium in patients with organic brain syndrome. American Journal of Psychiatry, 136, 800–803.PubMedGoogle Scholar
  115. Yudofsky, S., Williams, D., & Gorman, J. (1981). Propranolol in the treatment of rage and violent behavior in patients with chronic brain syndromes. American Journal of Psychiatry, 138, 218–220.PubMedGoogle Scholar
  116. Zeff, K., & Chung, R. (1987). Traumatic brain injury as an etiology of organic affective syndrome. Military Medicine, 152, 529–530.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Leslie K. Ross
    • 1
    • 2
  1. 1.Department of PsychologyMemphis State UniversityMemphisUSA
  2. 2.University of Tennessee Center for the Health SciencesMemphisUSA

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