Synthesis of New Poly(Ethylene Glycol) Derivatives
The chapters of this book describe the synthesis and use of a variety of active PEG derivatives designed to couple PEG to other materials. Despite the availability of these derivatives, there remains a need for new derivatives with presently unavailable properties and work continues in this area. Desirable properties include selectivity, stability, and ease of preparation. For example, it would be desirable to have derivatives that react with nucleophilic groups on proteins, but which do not react with water. Derivatives of a wide range of reactivities are always in demand. Similarly, there would be advantages to having derivatives that react with groups other than the commonly used amino groups. And, of course, the need for derivatives that can be prepared cheaply and easily in large quantity is critical for commercialization of the many biomedical and biotechnical applications of PEG chemistry.
KeywordsTetraethylene Glycol Silyl Group Single Terminus Tetrabutyl Ammonium Fluoride Oligoethylene Glycol
Unable to display preview. Download preview PDF.
- 1.J. M. Harris and M. Yalpani, in: Partitioning in Aqueous Two Phase Systems (H. Walter, D. E. Brooks, and D. Fisher, eds.), Chapter 12, Academic Press, New York (1985).Google Scholar
- 2.J. M. Harris, K. Yoshinaga, M. S. Paley, and M. R. Herati, in: Separations Using Aqueous Phase Systems: Applications in Cell Biology and Biotechnology (D. Fisher and I.A. Sutherland, eds.), Chap. 5.3, pp. 201–210, Plenum Press, London (1989).Google Scholar
- 3.J. M. Harris, J. M. Dust, R. A. McGill, P. A. Harris, M. J. Edgell, M. R. Sedaghat-Herati, L. J. Karr, and D. L. Donnelly, in: Water Soluble Polymers, (S. W. Shalaby, C. L. McCormick, and G. B. Butler, eds.), pp. 418–429, ACS Symp. Ser. 467 (1991).Google Scholar
- 6.Y. Nakutsuji, N. Kameda, and M. Okahara, Synthesis, 280 (1987).Google Scholar
- 7.K. K. Olgivie and D. J. Iwacha, Tetrahedron Lett., 317 (1973).Google Scholar
- 8.J. M. Harris and R. S. Herati, Polym. Prepr. 32(1), 154 (1991).Google Scholar
- 9.L. Field, Synthesis, 101 (1972).Google Scholar
- 11.G. P. Speranza, US Patent 3,231,619 (1966).Google Scholar
- 14.S. Zalipsky and G. Barany, Poly. Preprints 27(1), 1 (1986).Google Scholar
- 19.K. Bridger and B. Vincent, Polymer J. 16, 1017 (1980).Google Scholar