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Use of Functionalized Poly(Ethylene Glycol)s for Modification of Polypeptides

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Poly(Ethylene Glycol) Chemistry

Part of the book series: Topics in Applied Chemistry ((TAPP))

Abstract

The unique properties of poly(ethylene glycol) (or PEG) and its general compatibility with polypeptide materials facilitated development of a variety of different applications of this polymer.1–11 A marked proportion of these applications involve the use of covalently linked polypeptide-PEG adducts (reviewed elsewhere5–11). For example, a number of PEG-enzymes were shown to be useful as catalysts, soluble and active in organic solvents.7 Due to the affinity to the upper phase of PEG/Dextran and PEG/salt two-phase systems, PEG-modified proteins were proven useful both as diagnostic tools8 and in preparative separations of biological cells.9

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  1. Samuel Zalipsky

    Present address: Department of Chemistry, Rutgers-The State University of New Jersey, Piscataway, New Jersey, 08855, USA

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  1. Enzon, Inc., South Plainfield, New Jersey, 07080, USA

    Samuel Zalipsky & Chyi Lee

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  1. Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama, 35899, USA

    J. Milton Harris

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Zalipsky, S., Lee, C. (1992). Use of Functionalized Poly(Ethylene Glycol)s for Modification of Polypeptides. In: Harris, J.M. (eds) Poly(Ethylene Glycol) Chemistry. Topics in Applied Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0703-5_21

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