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PEO-Modified Surface-In Vitro, Ex Vivo, and In Vivo Blood Compatibility

  • Ki Dong Park
  • Sung Wan Kim
Part of the Topics in Applied Chemistry book series (TAPP)

Abstract

Thrombus formation is a serious problem in surgical therapy and clinical application of artificial organs. Therefore, the need for the creation of highly antithrombogenic biomaterials has been increasing. Although a substantial amount of work in the improvement of the blood compatibility of polymeric materials has been carried out, the results are still inconclusive. This is caused partly by the fact that the relationship between surface properties and surface-induced thrombosis has not been thoroughly evaluated.

Keywords

Protein Adsorption Graft Copolymer Triblock Copolymer Blood Compatibility Occlusion Time 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    M. Szycher, in: Biocompatible Polymers, Metals and Composites (M. Szycher, ed.), p. 1, Technomic Pub. Co., Inc., Lancaster, PA (1983).Google Scholar
  2. 2.
    D. Ogston, in: The Physiology of Hemostatis, p. 1, Harvard Press, Cambridge, MA (1983).CrossRefGoogle Scholar
  3. 3.
    M. Wintrobe, Clinical Hematology, p. 405, Lea and Febiger, Philadelphia, PA (1981).Google Scholar
  4. 4.
    S. W. Kim and J. Feijen, in: CRC Critical Reviews in Biocompatibility (D. Williams, ed.), Vol. 1, p. 229, CRC Press, Boca Raton, FL (1985).Google Scholar
  5. 5.
    J. D. Andrade, S. Nagaoka, S. L. Cooper, T. Okano, and S. W. Kim, ASAIO J. 10, 75 (1987).CrossRefGoogle Scholar
  6. 6.
    B. D. Ratner, A. S. Hoffman, and J. D. Whiffen, J. Bioeng. 2, 313 (1978).PubMedGoogle Scholar
  7. 7.
    Y. Mori, S. Nagaoka, H. Takiuchi, T. Kikuchi, N. Noguchi, H. Tanzawa, and Y. Noshiki, Trans. ASAIO 28, 496 (1982).Google Scholar
  8. 8.
    H. P Kim, S. M. Byun, Y. I. Yeom, and S. W. Kim, J. Pharm. Sci. 72, 225 (1983).PubMedCrossRefGoogle Scholar
  9. 9.
    T. Ohshiro and G. Kosaki, Int. J. Artif. Organs 4, 58 (1980).CrossRefGoogle Scholar
  10. 10.
    C. D. Ebert, E. S. Lee, and S. W. Kim, J. Biomed. Mater. Res. 16, 629 (1982).PubMedCrossRefGoogle Scholar
  11. 11.
    J. Y. Lin, T. Okano, L. Dost, J. Feijen, and S. W. Kim, Trans. ASAIO 31, 468 (1982).Google Scholar
  12. 12.
    P. W. Heyman and S. W. Kim, Makromol. Chem. 9, 119 (1985).CrossRefGoogle Scholar
  13. 13.
    S. W. Kim, Med. Dev. Diag. Ind. 8, 99 (1984).Google Scholar
  14. 14.
    W. E. Burkel, L. M. Graham, and J. C. Stanley, Ann. N.Y. Acad. Sci. 516, 131 (1986).CrossRefGoogle Scholar
  15. 15.
    M. A. Packman, G. Evans, M. F. Glkynn, and J. F Mustard, J. Lab. Clin. Med. 73, 686 (1979).Google Scholar
  16. 16.
    N. A. Plate and L. I. Valuev, Biomaterials 4, 14 (1983).PubMedCrossRefGoogle Scholar
  17. 17.
    C. D. Ebert and S. W. Kim, Thromb. Res. 26, 43 (1982).PubMedCrossRefGoogle Scholar
  18. 18.
    K. D. Park, T. Okano, C. Nojiri, and S. W. Kim, J. Biomed. Mat. Res. 22, 977 (1988).CrossRefGoogle Scholar
  19. 19.
    P. K. Smith, A. K. Mallia, and G. T. Harmanson, Anal. Biochem. 109, 466 (1980).PubMedCrossRefGoogle Scholar
  20. 20.
    A. N. Teien, M. Lie, and N. Abildaard, Thromb. Res. 8, 413 (1976).PubMedCrossRefGoogle Scholar
  21. 21.
    S. I. Joen and J. D. Andrade, J. Colloid Interface Sci. 142, 159 (1991).CrossRefGoogle Scholar
  22. 22.
    K. D. Park, Ph.D. Dissertation, University of Utah (1990).Google Scholar
  23. 23.
    J. D. Andrade, Med. Instrum. 7, 110 (1976).Google Scholar
  24. 24.
    S. W. Kim, C. D. Ebertm, J. C. McRea, C. Briggs, S. M. Byun, and H. P Kim, Ann. N.Y Acad. Sci. 416, 513 (1983).PubMedCrossRefGoogle Scholar
  25. 25.
    C. Nojiri, T. Okano, D. Grainger, K. D. Park, S. Nakahama, K. Suzuki, and S. W. Kim, Trans. ASAIO 33, 596 (1987).Google Scholar
  26. 26.
    C. Nojiri, T. Okano, K. D. Park, and S. W. Kim, Trans. ASAIO 34, 386 (1988).Google Scholar
  27. 27.
    C. Nojiri, K. D. Park, T. Okano, and S. W. Kim, Trans. ASAIO 35, 357 (1989).CrossRefGoogle Scholar
  28. 28.
    C. Nojiri, T. Okano, H. A. Jacobs, K. D. Park, S. F Mohammad, D. B. Olsen, and S. W. Kim, J. Biomed. Mater. Res. 24, 1151 (1990).PubMedCrossRefGoogle Scholar
  29. 29.
    K. Park, S. R. Simmons, and R. M. Albrecht, Scanning Microsc. 1, 339 (1987).PubMedGoogle Scholar
  30. 30.
    Y. Noishiki, J. Biomed. Mater. Res. 16, 359 (1982).PubMedCrossRefGoogle Scholar
  31. 31.
    K. D. Park, A. Z. Piao, H. Jacobs, T. Okano, and S. W. Kim, J. Polym. Sci., Part A 29, 1725 (1991).CrossRefGoogle Scholar
  32. 32.
    K. D. Park, W. G. Kim, H. Jacobs, T. Okano, and S. W. Kim, J. Biomed. Mater. Res. (in press).Google Scholar
  33. 33.
    W. G. Kim, S. F. Mohammad, K. D. Park, and S. W. Kim, Trans. ASAIO 37, M148 (1991).Google Scholar
  34. 34.
    D. Grainger, J. Feijen, and S. W. Kim, J. Biomed. Mater. Res. 22, 231 (1988).PubMedCrossRefGoogle Scholar
  35. 35.
    D. Grainger, K. Knutson, S. W. Kim, and J. Feijen, J. Biomed. Mater. Res. 24, 403 (1990).PubMedCrossRefGoogle Scholar
  36. 36.
    D. Grainger, T. Okano, S. W. Kim, D. B. Castner, B. D. Ratner, D. Briggs, and Y. K. Sung, J. Biomed. Mater. Res. 24, 547 (1990).PubMedCrossRefGoogle Scholar
  37. 37.
    A. Z. Piao, C. Nojiri, K. D. Park, H. Jacobs, J. Feijen, and S. W. Kim, J. Biomater. Sci., Polym. Ed. 1, 299 (1990).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Ki Dong Park
    • 1
  • Sung Wan Kim
    • 1
  1. 1.Department of Pharmaceutics, Center for Controlled Chemical DeliveryUniversity of UtahSalt Lake CityUSA

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