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Toxicity of Bilirubin and Detoxification by PEG-Bilirubin Oxidase Conjugate

A New Tactic for Treatment of Jaundice
  • Hiroshi Maeda
  • Masami Kimura
  • Ikuharu Sasaki
  • Yoshihiko Hirose
  • Toshimitsu Konno
Part of the Topics in Applied Chemistry book series (TAPP)

Abstract

Bilirubin, the end product of heme catabolism, is generally regarded as toxic and highly fatal in newborn infants and fulminant hepatitis. Bilirubin encephalopathy (kernicterus) is usually considered to be caused by the entry of circulating, free (albumin-unbound), unconjugated bilirubin into the cerebral tissue.1,2 Bilirubin conjugation with glucuronic acid takes place in the liver and the process is impaired in liver diseases. Our tactic for the treatment of jaundice is to decompose toxic bilirubin by the enzyme bilirubin oxidase, and for that purpose the enzyme is made into a polymer conjugate to improve its pharmacological properties.3

Keywords

Degradation Product Obstructive Jaundice Neonatal Jaundice Unconjugated Bilirubin Cyanuric Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Hiroshi Maeda
    • 1
  • Masami Kimura
    • 1
  • Ikuharu Sasaki
    • 2
  • Yoshihiko Hirose
    • 2
  • Toshimitsu Konno
    • 1
  1. 1.Kumamoto University Medical SchoolKumamoto 860Japan
  2. 2.Amano Pharmaceutical Co., Ltd.Nagoya 481Japan

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