Skip to main content

The Role of Reproductive Hormones in Cardiovascular and Neuroendocrine Function during Behavioral Stress

  • Chapter
Individual Differences in Cardiovascular Response to Stress

Part of the book series: Perspectives on Individual Differences ((PIDF))

Abstract

The role of reproductive hormones—both male and female—in the development and progression of coronary heart disease has been studied by epidemiologists for many years, yet discrepancies in the epidemiological literature are widespread, no doubt due to the complexities of the human reproductive system itself. Despite the discrepancies, there is significant evidence that endogenous ovarian hormones—most likely the estrogens—serve a cardioprotective role for women. In some cases, and in small doses, certain exogenous estrogens might also be protective against heart disease. There is little doubt that both endogenous and exogenous reproductive hormones play a complicated role in modulating the risk of coronary heart disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams, M. R., Kaplan, J. R., Koritnik, D. R., & Clarkson, T. B. (1987). Pregnancy-associated inhibition of coronary artery atherosclerosis in monkeys. Evidence of a relationship with endogenous estrogen. Arteriosclerosis, 7, 378–384.

    Article  PubMed  Google Scholar 

  • Barron, W. M., Mujais, S. K, Zinaman, M., Bravo, E. L., & Lindheimer, M. D. (1986). Plasma catecholamine responses to physiologic stimuli in normal human pregnancy. American Journal of Obstetrics and Gynecology, 154, 80–84.

    PubMed  Google Scholar 

  • Bean, J. A., Leeper, J. D., Wallace, R. B., Sherman, B. M., & Treloar, A. W. (1979). Variation in the reporting of menstrual histories. American Journal of Epidemiology, 109, 181–185.

    PubMed  Google Scholar 

  • Bush, T. L., & Barrett-Connor, E. (1985). Noncontraceptive estrogen use and cardiovascular disease. Epidemiologiec Reviews, 7, 80–104.

    Google Scholar 

  • Carroll, D., Turner, J. R., Lee, H. J., & Stephenson, J. (1984). Temporal consistency of individual differences in cardiac response to a video game. Biological Psychology, 19, 81–93.

    Article  PubMed  Google Scholar 

  • Cole, P. L., & Sutton, M. St. J., (1989). Normal cardiopulmonary adjustments to pregnancy: Cardiovascular evaluation. In P. S. Douglas (Ed.), Heart disease in women Philadelphia: F. A. Davis.

    Google Scholar 

  • Collins, A., Hanson, I., Eneroth, P., Hagenfeldt, K., Lundberg, U., & Frankenhaeuser, M. (1982). Psychophysiological stress responses in postmenopausal women before and after hormonal replacement therapy. Human Neurobiology, 1, 153–159.

    PubMed  Google Scholar 

  • Collins, A., Eneroth, P., & Landgren, B.-M. (1985). Psychoneuroendocrine stress responses and mood as related to the menstrual cycle. Psychosomatic Medicine, 47(6), 512–527.

    PubMed  Google Scholar 

  • Coronary Drug Project Research Group (1973). The Coronary Drug Project findings leading to discontinuation of the 2.5 mg/day estrogen group. Journal of the American Medical Association, 226, 652–657.

    Article  Google Scholar 

  • Cuche, J.-L., Kuchel, O., Barbeau, A., & Genest, J. (1975). Sex differences in the urinary catecholamines. Endocrine Research Communications, 2, 549–559.

    PubMed  Google Scholar 

  • Davis, M. C., & Matthews, K. A. (1990). Cigarette smoking and oral contraceptive use influence women’s lipid, lipoprotein, neuroendocrine, and cardiovascular responses during stress. Health Psychology, 9, 717–736.

    Article  PubMed  Google Scholar 

  • Dimsdale, J. E., Pierce, C., Schoenfeld, D., Brown, A., Zusman, R., & Graham, R. (1986). Suppressed anger and blood pressure: The effects of race, sex, social class, obesity, and age. Psychosomatic Medicine, 48, 430–436.

    PubMed  Google Scholar 

  • Emmons, K. M., & Weidner, G. (1988). The effects of cognitive and physical stress on cardiovascular reactivity among smokers and oral contraceptive users. Psychophysiology, 25, 166–171.

    Article  PubMed  Google Scholar 

  • Garrett, K. F., & Elder, S. T. (1984). The menstrual cycle from a bio-behavioral approach: A comparison of oral contraceptive and non-contraceptive users. International Journal of Psychophysiology, 1, 209–214.

    Article  PubMed  Google Scholar 

  • Girdler, S. S., Turner, J. R., Sherwood, A., & Light, K. C. (1990). Gender differences in blood pressure control during a variety of behavioral Stressors. Psychosomatic Medicine, 52, 571–591.

    PubMed  Google Scholar 

  • Hastrup, J. L., & Light, K. C. (1984). Sex differences in cardiovascular stress responses: Modulation as a function of menstrual cycle phases. Journal of Psychosomatic Research, 28, 475–483.

    Article  PubMed  Google Scholar 

  • Hastrup, J. L., Kraemer, D. L., & Phillips, S. M. (1986). Blood pressure and heart rate of women under 45 following total hysterectomy: Effects of stress and family history of hypertension. Presentation at the annual meeting of the Society for Psychophysiological Research, Montreal.

    Google Scholar 

  • Jick, H., Dinan, B., & Rothman, K. J. (1978). Oral contraceptive, and nonfatal myocardial infarction. Journal of the American Medical Association, 239, 1403–1406.

    Article  PubMed  Google Scholar 

  • Kaplan, B. J., Whitsett, S. F., & Robinson, J. W. (1990). Menstrual cycle phase is a potential confound in psychophysiology research. Psychophysiology, 27, 445–450.

    Article  PubMed  Google Scholar 

  • Krailo, M. D., & Pike, M. C. (1983). Estimation of the distribution of age at natural menopause from prevalence data. American Journal of Epidemiology, 117, 356.

    PubMed  Google Scholar 

  • Krantz, D. S., & Manuck, S. B. (1984). Acute psychophysiological reactivity and risk of cardiovascular disease: A review and methodologic critique. Psychological Bulletin, 96, 435–464.

    Article  PubMed  Google Scholar 

  • Ladisich, W. (1977). Influence of progesterone on serotonin metabolism: A possible causal factor for mood changes. Psychoneuroendocrinology, 2, 257–266.

    Article  PubMed  Google Scholar 

  • Little, B., & Zahn, R. P. (1974). Changes in mood and autonomie functioning during the menstrual cycle. Psychophysiology, 11, 579–590.

    Article  PubMed  Google Scholar 

  • Marinari, K. T., Leshner, A. I., & Doyle, M. P. (1976). Menstrual cycle status and adrenocortical reactivity to psychological stress. Psychoneuroendocrinology, 1, 213–218.

    Article  PubMed  Google Scholar 

  • Matthews, K. A., & Rodin, J. (1992). Pregnancy alters blood pressure responses to psychological and physical challenge. Psychophysiology, 29, 236–244.

    Article  Google Scholar 

  • Matthews, K. A., & Stoney, C. M. (1988). Influences of sex and age on cardiovascular responses during stress. Psychosomatic Medicine, 50, 46–56.

    PubMed  Google Scholar 

  • Neus, H., & von Eiff, A. W. (1985). Selected topics in the methodology of stress testing: Time course, gender and adaptation. In A. Steptoe, H. Ruddel, & H. Neus (Eds.), Clinical and methodological issues in cardiovascvlar psychophysiology (pp. 78–92). Berlin: Springer-Verlag.

    Chapter  Google Scholar 

  • Nisell, H., Hjemdahl, P., Linde, B., & Lunell, N.-O. (1985). Sympatho-adrenal and cardiovascular reactivity in pregnancy-induced hypertension. I. Responses to isometric exercise and a cold pressor test. British Journal of Obstetrics and Gynaecology, 92, 722–731.

    Article  PubMed  Google Scholar 

  • Pauerstein, C. J., Eddy, C. A., Croxatto, H. D., Hess, R., Siler-Khodr, T. M., & Croxatto, H. B. (1978). Temporal relationships of estrogen, progesterone, and luteinizing hormone levels to ovulation in women and infrahuman primates. American Journal of Obstetrics and Gynecology, 130, 876.

    PubMed  Google Scholar 

  • Plante, T. G., & Denney, D. R. (1984). Stress responsivity among dysmenorrheic women at different phases of their menstrual cycle: More ado about nothing. Behaviour Research and Therapy, 22, 249–258.

    Article  PubMed  Google Scholar 

  • Polefrone, J. M., & Manuck, S. B. (1988). Effects of menstrual phase and parental history of hypertension on cardiovascular response to cognitive challenge. Psychosomatic Medicine, 50, 23–36.

    PubMed  Google Scholar 

  • Rice, D. P., Hing, E., Kovar, M. G., & Prager, K. (1984). Sex differences in disease risk. In E. B. Gold (Ed.), The changing risk of disease in women (pp. 1–24). Lexington, MA: Collamore Press.

    Google Scholar 

  • Saab, P. G. (1989). Cardiovascular and neuroendocrine responses to challenge in males and females. In N. Schneiderman, S. M. Weiss, P. G. Kaufmann (Eds.), Handbook of research methods in cardiovascvlar behavioral medicine (pp. 453–481). New York: Plenum Press.

    Google Scholar 

  • Saab, P. G., Matthews, K. A., Stoney, C. M., & McDonald, R. H. (1989). Premenopausal and postmenopausal women differ in their cardiovascular and neuroendocrine responses to behavioral Stressors. Psychophysiology, 26, 270–280.

    Article  PubMed  Google Scholar 

  • Speroff, L., Glass, R. H., & Kase, N. G. (1989). Clinical gynecologic endocrinology and infertility. (4th ed.). Baltimore: Williams & Wilkins.

    Google Scholar 

  • Stamfer, M. J., Willett, W. C., Colditz, G. A., Rosner, B., Speizer, F. E., & Hennekens, C. H. (1985). A prospective study of postmenopausal estrogen therapy and coronary heart disease. The New England Journal of Medicine, 313, 1044–1049.

    Article  Google Scholar 

  • Stern, M. P., Brown, B. W., Haskell, W. L., Farquhar, J. W., Wehrle, C. L., & Wood, D. S. (1976). Cardiovascular risk and use of estrogens or estrogen/progesterone combinations. Journal of the American Medical Association, 235, 811–815.

    Article  PubMed  Google Scholar 

  • Stoney, C. M., & Matthews, K. A. (1988). Parental history of hypertension and myocardial infarction predicts cardiovascular responses to behavioral Stressors in middle-aged men and women. Psychophysiology, 25, 269–277.

    Article  PubMed  Google Scholar 

  • Stoney, C. M., Langer, A. W., & Gelling, P. D. (1986). The effects of menstrual cycle phase on cardiovascular and pulmonary responses to behavioral and exercise stress. Psychophysiology, 23, 393–402.

    Article  PubMed  Google Scholar 

  • Stoney, C. M., Davis, M. C., & Matthews, K. A. (1987). Sex differences in physiological responses to stress and in coronary heart disease: A causal link?. Psychophysiology, 24, 127–131.

    Article  PubMed  Google Scholar 

  • Stoney, C. M., Matthews, K. A., McDonald, R. H., & Johnson, C. A. (1988). Sex differences in lipid, lipoprotein, cardiovascular and neuroendocrine responses to acute stress. Psychophysiology, 25, 645–656.

    Article  PubMed  Google Scholar 

  • Stoney, C. M., Owens, J. F., Matthews, K. A., Davis, M. C., & Caggiula, A. (1990). Influences of the normal menstrual cycle on physiologic functioning during behavioral stress. Psychophysiology, 27, 125–135.

    Article  PubMed  Google Scholar 

  • Talbott, E. O., Kuller, L. H., Detre, K., Matthews, K. A., Norman, S., Kelsey, S. F., & Belle, S. (1989). Reproductive history of women dying of sudden cardiac death: A case-control study. International Journal of Epidemiology, 18, 589–594.

    Article  PubMed  Google Scholar 

  • Tanner, J. M. (1962). Growth at adolescence. Springfield, IL: Thomas.

    Google Scholar 

  • Treloar, A. E. (1976). Variation in the human menstrual cycle. Proceedings of the Research Conference on National Family Planning (pp. 64–71). Washington, DC: Human Life Foundation.

    Google Scholar 

  • van Doornen, L. J. P. (1986). Sex differences in physiological reactions to real life stress and their relationship to psychological variables. Psychophysiology, 23, 657–662.

    Article  PubMed  Google Scholar 

  • Veldhuis, J. D., Christiansen, E., Evans, W. S., Kolp, L. A., Rogol, A. D., & Johnson, M. L. (1988). Physiological profiles of episodic progesterone release during the midcycle phase of the human menstrual cycle: Analysis of circadian and ultradian rhythms, discrete pulse properties, and correlations with simultaneous luteinizing hormone release. Journal of Clinical Endocrinology and Metabolism, 62, 414–421.

    Article  Google Scholar 

  • von Eiff, A. W., Plotz, E. J., Beck, K. J., & Czernik, A. (1971). The effect of estrogens and progestins on blood pressure regulation of normotensive women. American Journal of Obstetrics and Gynecology, 109, 887–892.

    Google Scholar 

  • Weidner, G., Friend, R., Ficarrotto, T. J., & Mendell, N. R. (1989). Hostility and cardiovascular reactivity to stress in women and men. Psychosomatic Medicine, 51, 36–45.

    PubMed  Google Scholar 

  • Wingard, D. L. (1982). The sex differential in mortality rate: Demographic and behavioral factors. American Journal of Epidemiology, 115, 205–216.

    PubMed  Google Scholar 

  • Wingard, D. L., Suarez, L., & Barrett-Connor, E. (1983). The sex differential in mortality from all causes and ischemic heart disease. American Journal of Epidemiology, 117, 165–172.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Stoney, C.M. (1992). The Role of Reproductive Hormones in Cardiovascular and Neuroendocrine Function during Behavioral Stress. In: Turner, J.R., Sherwood, A., Light, K.C. (eds) Individual Differences in Cardiovascular Response to Stress. Perspectives on Individual Differences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0697-7_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0697-7_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0699-1

  • Online ISBN: 978-1-4899-0697-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics