Abstract
The role of reproductive hormones—both male and female—in the development and progression of coronary heart disease has been studied by epidemiologists for many years, yet discrepancies in the epidemiological literature are widespread, no doubt due to the complexities of the human reproductive system itself. Despite the discrepancies, there is significant evidence that endogenous ovarian hormones—most likely the estrogens—serve a cardioprotective role for women. In some cases, and in small doses, certain exogenous estrogens might also be protective against heart disease. There is little doubt that both endogenous and exogenous reproductive hormones play a complicated role in modulating the risk of coronary heart disease.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adams, M. R., Kaplan, J. R., Koritnik, D. R., & Clarkson, T. B. (1987). Pregnancy-associated inhibition of coronary artery atherosclerosis in monkeys. Evidence of a relationship with endogenous estrogen. Arteriosclerosis, 7, 378–384.
Barron, W. M., Mujais, S. K, Zinaman, M., Bravo, E. L., & Lindheimer, M. D. (1986). Plasma catecholamine responses to physiologic stimuli in normal human pregnancy. American Journal of Obstetrics and Gynecology, 154, 80–84.
Bean, J. A., Leeper, J. D., Wallace, R. B., Sherman, B. M., & Treloar, A. W. (1979). Variation in the reporting of menstrual histories. American Journal of Epidemiology, 109, 181–185.
Bush, T. L., & Barrett-Connor, E. (1985). Noncontraceptive estrogen use and cardiovascular disease. Epidemiologiec Reviews, 7, 80–104.
Carroll, D., Turner, J. R., Lee, H. J., & Stephenson, J. (1984). Temporal consistency of individual differences in cardiac response to a video game. Biological Psychology, 19, 81–93.
Cole, P. L., & Sutton, M. St. J., (1989). Normal cardiopulmonary adjustments to pregnancy: Cardiovascular evaluation. In P. S. Douglas (Ed.), Heart disease in women Philadelphia: F. A. Davis.
Collins, A., Hanson, I., Eneroth, P., Hagenfeldt, K., Lundberg, U., & Frankenhaeuser, M. (1982). Psychophysiological stress responses in postmenopausal women before and after hormonal replacement therapy. Human Neurobiology, 1, 153–159.
Collins, A., Eneroth, P., & Landgren, B.-M. (1985). Psychoneuroendocrine stress responses and mood as related to the menstrual cycle. Psychosomatic Medicine, 47(6), 512–527.
Coronary Drug Project Research Group (1973). The Coronary Drug Project findings leading to discontinuation of the 2.5 mg/day estrogen group. Journal of the American Medical Association, 226, 652–657.
Cuche, J.-L., Kuchel, O., Barbeau, A., & Genest, J. (1975). Sex differences in the urinary catecholamines. Endocrine Research Communications, 2, 549–559.
Davis, M. C., & Matthews, K. A. (1990). Cigarette smoking and oral contraceptive use influence women’s lipid, lipoprotein, neuroendocrine, and cardiovascular responses during stress. Health Psychology, 9, 717–736.
Dimsdale, J. E., Pierce, C., Schoenfeld, D., Brown, A., Zusman, R., & Graham, R. (1986). Suppressed anger and blood pressure: The effects of race, sex, social class, obesity, and age. Psychosomatic Medicine, 48, 430–436.
Emmons, K. M., & Weidner, G. (1988). The effects of cognitive and physical stress on cardiovascular reactivity among smokers and oral contraceptive users. Psychophysiology, 25, 166–171.
Garrett, K. F., & Elder, S. T. (1984). The menstrual cycle from a bio-behavioral approach: A comparison of oral contraceptive and non-contraceptive users. International Journal of Psychophysiology, 1, 209–214.
Girdler, S. S., Turner, J. R., Sherwood, A., & Light, K. C. (1990). Gender differences in blood pressure control during a variety of behavioral Stressors. Psychosomatic Medicine, 52, 571–591.
Hastrup, J. L., & Light, K. C. (1984). Sex differences in cardiovascular stress responses: Modulation as a function of menstrual cycle phases. Journal of Psychosomatic Research, 28, 475–483.
Hastrup, J. L., Kraemer, D. L., & Phillips, S. M. (1986). Blood pressure and heart rate of women under 45 following total hysterectomy: Effects of stress and family history of hypertension. Presentation at the annual meeting of the Society for Psychophysiological Research, Montreal.
Jick, H., Dinan, B., & Rothman, K. J. (1978). Oral contraceptive, and nonfatal myocardial infarction. Journal of the American Medical Association, 239, 1403–1406.
Kaplan, B. J., Whitsett, S. F., & Robinson, J. W. (1990). Menstrual cycle phase is a potential confound in psychophysiology research. Psychophysiology, 27, 445–450.
Krailo, M. D., & Pike, M. C. (1983). Estimation of the distribution of age at natural menopause from prevalence data. American Journal of Epidemiology, 117, 356.
Krantz, D. S., & Manuck, S. B. (1984). Acute psychophysiological reactivity and risk of cardiovascular disease: A review and methodologic critique. Psychological Bulletin, 96, 435–464.
Ladisich, W. (1977). Influence of progesterone on serotonin metabolism: A possible causal factor for mood changes. Psychoneuroendocrinology, 2, 257–266.
Little, B., & Zahn, R. P. (1974). Changes in mood and autonomie functioning during the menstrual cycle. Psychophysiology, 11, 579–590.
Marinari, K. T., Leshner, A. I., & Doyle, M. P. (1976). Menstrual cycle status and adrenocortical reactivity to psychological stress. Psychoneuroendocrinology, 1, 213–218.
Matthews, K. A., & Rodin, J. (1992). Pregnancy alters blood pressure responses to psychological and physical challenge. Psychophysiology, 29, 236–244.
Matthews, K. A., & Stoney, C. M. (1988). Influences of sex and age on cardiovascular responses during stress. Psychosomatic Medicine, 50, 46–56.
Neus, H., & von Eiff, A. W. (1985). Selected topics in the methodology of stress testing: Time course, gender and adaptation. In A. Steptoe, H. Ruddel, & H. Neus (Eds.), Clinical and methodological issues in cardiovascvlar psychophysiology (pp. 78–92). Berlin: Springer-Verlag.
Nisell, H., Hjemdahl, P., Linde, B., & Lunell, N.-O. (1985). Sympatho-adrenal and cardiovascular reactivity in pregnancy-induced hypertension. I. Responses to isometric exercise and a cold pressor test. British Journal of Obstetrics and Gynaecology, 92, 722–731.
Pauerstein, C. J., Eddy, C. A., Croxatto, H. D., Hess, R., Siler-Khodr, T. M., & Croxatto, H. B. (1978). Temporal relationships of estrogen, progesterone, and luteinizing hormone levels to ovulation in women and infrahuman primates. American Journal of Obstetrics and Gynecology, 130, 876.
Plante, T. G., & Denney, D. R. (1984). Stress responsivity among dysmenorrheic women at different phases of their menstrual cycle: More ado about nothing. Behaviour Research and Therapy, 22, 249–258.
Polefrone, J. M., & Manuck, S. B. (1988). Effects of menstrual phase and parental history of hypertension on cardiovascular response to cognitive challenge. Psychosomatic Medicine, 50, 23–36.
Rice, D. P., Hing, E., Kovar, M. G., & Prager, K. (1984). Sex differences in disease risk. In E. B. Gold (Ed.), The changing risk of disease in women (pp. 1–24). Lexington, MA: Collamore Press.
Saab, P. G. (1989). Cardiovascular and neuroendocrine responses to challenge in males and females. In N. Schneiderman, S. M. Weiss, P. G. Kaufmann (Eds.), Handbook of research methods in cardiovascvlar behavioral medicine (pp. 453–481). New York: Plenum Press.
Saab, P. G., Matthews, K. A., Stoney, C. M., & McDonald, R. H. (1989). Premenopausal and postmenopausal women differ in their cardiovascular and neuroendocrine responses to behavioral Stressors. Psychophysiology, 26, 270–280.
Speroff, L., Glass, R. H., & Kase, N. G. (1989). Clinical gynecologic endocrinology and infertility. (4th ed.). Baltimore: Williams & Wilkins.
Stamfer, M. J., Willett, W. C., Colditz, G. A., Rosner, B., Speizer, F. E., & Hennekens, C. H. (1985). A prospective study of postmenopausal estrogen therapy and coronary heart disease. The New England Journal of Medicine, 313, 1044–1049.
Stern, M. P., Brown, B. W., Haskell, W. L., Farquhar, J. W., Wehrle, C. L., & Wood, D. S. (1976). Cardiovascular risk and use of estrogens or estrogen/progesterone combinations. Journal of the American Medical Association, 235, 811–815.
Stoney, C. M., & Matthews, K. A. (1988). Parental history of hypertension and myocardial infarction predicts cardiovascular responses to behavioral Stressors in middle-aged men and women. Psychophysiology, 25, 269–277.
Stoney, C. M., Langer, A. W., & Gelling, P. D. (1986). The effects of menstrual cycle phase on cardiovascular and pulmonary responses to behavioral and exercise stress. Psychophysiology, 23, 393–402.
Stoney, C. M., Davis, M. C., & Matthews, K. A. (1987). Sex differences in physiological responses to stress and in coronary heart disease: A causal link?. Psychophysiology, 24, 127–131.
Stoney, C. M., Matthews, K. A., McDonald, R. H., & Johnson, C. A. (1988). Sex differences in lipid, lipoprotein, cardiovascular and neuroendocrine responses to acute stress. Psychophysiology, 25, 645–656.
Stoney, C. M., Owens, J. F., Matthews, K. A., Davis, M. C., & Caggiula, A. (1990). Influences of the normal menstrual cycle on physiologic functioning during behavioral stress. Psychophysiology, 27, 125–135.
Talbott, E. O., Kuller, L. H., Detre, K., Matthews, K. A., Norman, S., Kelsey, S. F., & Belle, S. (1989). Reproductive history of women dying of sudden cardiac death: A case-control study. International Journal of Epidemiology, 18, 589–594.
Tanner, J. M. (1962). Growth at adolescence. Springfield, IL: Thomas.
Treloar, A. E. (1976). Variation in the human menstrual cycle. Proceedings of the Research Conference on National Family Planning (pp. 64–71). Washington, DC: Human Life Foundation.
van Doornen, L. J. P. (1986). Sex differences in physiological reactions to real life stress and their relationship to psychological variables. Psychophysiology, 23, 657–662.
Veldhuis, J. D., Christiansen, E., Evans, W. S., Kolp, L. A., Rogol, A. D., & Johnson, M. L. (1988). Physiological profiles of episodic progesterone release during the midcycle phase of the human menstrual cycle: Analysis of circadian and ultradian rhythms, discrete pulse properties, and correlations with simultaneous luteinizing hormone release. Journal of Clinical Endocrinology and Metabolism, 62, 414–421.
von Eiff, A. W., Plotz, E. J., Beck, K. J., & Czernik, A. (1971). The effect of estrogens and progestins on blood pressure regulation of normotensive women. American Journal of Obstetrics and Gynecology, 109, 887–892.
Weidner, G., Friend, R., Ficarrotto, T. J., & Mendell, N. R. (1989). Hostility and cardiovascular reactivity to stress in women and men. Psychosomatic Medicine, 51, 36–45.
Wingard, D. L. (1982). The sex differential in mortality rate: Demographic and behavioral factors. American Journal of Epidemiology, 115, 205–216.
Wingard, D. L., Suarez, L., & Barrett-Connor, E. (1983). The sex differential in mortality from all causes and ischemic heart disease. American Journal of Epidemiology, 117, 165–172.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Stoney, C.M. (1992). The Role of Reproductive Hormones in Cardiovascular and Neuroendocrine Function during Behavioral Stress. In: Turner, J.R., Sherwood, A., Light, K.C. (eds) Individual Differences in Cardiovascular Response to Stress. Perspectives on Individual Differences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0697-7_8
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0697-7_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0699-1
Online ISBN: 978-1-4899-0697-7
eBook Packages: Springer Book Archive