Endogenous Opioids and Stress Reactivity in the Development of Essential Hypertension

  • James A. McCubbin
  • Robyn Cheung
  • Thomas B. Montgomery
  • Ronald Bulbulian
  • John F. Wilson
Part of the Perspectives on Individual Differences book series (PIDF)


The mechanistic bases of individual differences in cardiovascular stress reactivity are not fully understood. Variations in blood pressure and heart rate reactivity are believed to correspond to autonomic nervous system activity, but the precise neuroendocrine origins of these response differences have not been characterized. Equally deficient is an appreciation of the clinical significance of these individual differences in reactivity. This chapter will highlight a series of experiments designed to investigate the neuroendocrine origin and possible clinical significance of individual differences in cardiovascular reactivity during behavioral stress.


Blood Pressure Response Endogenous Opioid Autonomic Nervous System Activity Heart Rate Reactivity Blood Pressure Reactivity 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • James A. McCubbin
    • 1
  • Robyn Cheung
    • 1
  • Thomas B. Montgomery
    • 2
  • Ronald Bulbulian
    • 3
  • John F. Wilson
    • 1
  1. 1.Department of Behavioral ScienceUniversity of Kentucky College of MedicineLexingtonUSA
  2. 2.Department of MedicineUniversity of Kentucky College of MedicineLexingtonUSA
  3. 3.Department of Health, Physical Education, and RecreationUniversity of Kentucky College of EducationLexingtonUSA

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