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Biological Markers

  • Stephen D. Samuelson
  • George Winokur
Part of the Critical Issues in Psychiatry book series (CIPS)

Abstract

A biological finding which discriminates between psychiatric diseases or disease subtypes, or which predicts treatment response or relapse, would be useful in research and clinical efforts alike. A biologic test which predicts genetic vulnerability would also be useful to those who are interested in studying heritable forms of illness. Trait markers identify vulnerability to a disease and are present regardless of whether the individual is actually ill. Alternatively, state markers are found only in currently affected patients, and might help with diagnostic, prognostic, and therapeutic decisions.

Keywords

Panic Disorder Panic Attack Mitral Valve Prolapse Dexamethasone Suppression Test Biological Psychiatry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Amsterdam, J. D., Maislin, G., Gold, E., & Winokur, A. (1989). The assessment of abnormalities in hormonal responsiveness at multiple levels of the HPA axis in depressive illness. Psychoneuroendocrinology, 14, 43–62.PubMedGoogle Scholar
  2. Amsterdam, J. D., Maislin, G., Skolnick, B., Berwish, N., & Winokur, A. (1989). Multiple hormone responses to clonidine administration in depressed patients and healthy volunteers. Biological Psychiatry, 26, 265–278.PubMedGoogle Scholar
  3. Andreasen, N., Carson, R., Evans, A., Farde, L., Gjedde, A., Hakim, A., Lal, S., Nair, N., Sedvall, G., Tune, L., & Wong, D. (1988). Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum. Schizophrenia Bulletin, 3, 471–484.Google Scholar
  4. Andreasen, N. C., Ehrhardt, J. C., Swayze, V. W., Alliger, R. J., Yuh, W. T. C., Cohen, G., & Ziebell, S. (1990). Magnetic resonance imaging of the brain in schizophrenia: The pathophysiologic significance of structural abnormalities. Archives of General Psychiatry, 47, 35–44.PubMedGoogle Scholar
  5. Ansseau, M., Scheyvaerts, M., Doumont, A., Poirrier, R., Legros, J. J., & Frank, G. (1984). Concurrent use of REM latency, dexamethasone suppression, clonidine and apomorphine tests as biological markers of endogenous depression: A pilot study. Psychiatry Research, 12, 261–272.PubMedGoogle Scholar
  6. Ansseau, M., Von Frenckell, R., Cerfontaine, J. L., Papart, P., Frank, S., Timsit-Berthier, M., Geenen, V., & Legros, J. J. (1988). Blunted response of growth hormone to clonidine and apomorphine in endogenous depression. British Journal of Psychiatry, 153, 65–71.PubMedGoogle Scholar
  7. APA Task Force on Laboratory Tests in Psychiatry. (1987). The dexamethasone suppression test: An overview of its current status in psychiatry. American Journal of Psychiatry, 114, 1253–1262.Google Scholar
  8. Arana, G. W., Baldessarini, R. J., & Ornsteen, M. (1985). The dexamethasone suppression test for diagnosis and prognosis in psychiatry. Archives of General Psychiatry, 42, 1193–1204.PubMedGoogle Scholar
  9. Asnis, G. M., Halbreich, U., Nathan, R. S., Ostrow, L., Novacenko, H., Endicott, J., & Sachar, E. J. (1982). The dexamethasone suppression test in depressive illness: Clinical correlates. Psycho-neuroendocrinology, 7, 295–301.Google Scholar
  10. Balon, R., Pohl, R., Yeragani, V. K., Rainey, J. M., & Weinberg, P (1988). Lactate-and isoproterenol-induced panic attacks in panic disorder patients. Psychiatry Research, 23, 153–160.PubMedGoogle Scholar
  11. Balon, R., Yergani, V K., & Pohl, R. (1988). Phenomenological comparison of dextrose-, lactate-, and isoproterenol-associated panic attacks. Psychiatry Research, 26, 43–50.PubMedGoogle Scholar
  12. Balon, R., Jordan, M., Pohl, R., et al. (1989). Family history of anxiety disorders in control subjects with lactate-induced panic attacks. American Journal of Psychiatry, 146, 1304–1306.PubMedGoogle Scholar
  13. Baron, M., Barkai, A., Gruen, R., Peslow, E., Fieve, R., & Quitkin, F. (1986). Platelet [3H]imipramine binding in affective disorders: Trait versus state characteristics. American Journal of Psychiatry, 143, 711–717.PubMedGoogle Scholar
  14. Baxter, L. R., Phelps, M. E., Mazziotta, J. C., Schwartz, J. M., Gerner, R. H., Selin, C. E., & Sumida, R. M. (1985). Cerebral metabolic rates for glucose in mood disorders: Studies with positron emission tomography and fluorodeoxyglucose F18. Archives of General Psychiatry, 42, 441–447.PubMedGoogle Scholar
  15. Baxter, L. R., Schwartz, J. M., Phelps, M. E., Mazziotta, J. C., Guze, B. H., Selin, C. E., Gerner, R. H., & Sumida, R. M. (1989). Reduction of prefrontal cortex glucose metabolism common to three types of depression. Archives of General Psychiatry, 46, 243–250.PubMedGoogle Scholar
  16. Beauge, F., Stibler, H., & Borg, S. (1985). Abnormal fluidity and surface carbohydrate content of the erythrocyte membrane in alcoholic patients. Alcohol Clinical Experimental Research, 9, 322–327.Google Scholar
  17. Berger, M., Riemann, D., Hoechli, D., & Spiegel, R. (1989). The cholinergic rapid eye movement sleep induction test with RS-86. Archives of General Psychiatry, 46, 412–428.Google Scholar
  18. Berger, P. A., Faull, K. F., Kilkowski, J., Anderson, P. J., Kraemer, H., Davis, K. L., & Barchas, J. D. (1980). CSF monoamine metabolites in depression and schizophrenia. American Journal of Psychiatry, 137, 174–180.PubMedGoogle Scholar
  19. Berrettini, W. H., Nurnberger, J. I., Jr., Hare, T., Gershon, E. S., & Post, R. M., (1982). Plasma and CSF GABA in affective illness. British Journal of Psychiatry, 141, 483–488.PubMedGoogle Scholar
  20. Boismare, F., Lhuintre, J. P., Daoust, M., Moore, N., Saligaut, C., & Hillemand, B. (1987). Platelet affinity for serotonin is increased in alcoholics and former alcoholics: A biological marker for dependence? Alcohol & Alcoholism, 22, 155–159.Google Scholar
  21. Bowen, R. C., Orchard, R. C., Keegan, D. L., & D’Arcy, C. (1985). Mitral valve prolapse and psychiatric disorders. Psychosomatics, 26, 926–932.PubMedGoogle Scholar
  22. Brambilla, E., Ferrari, E., Invitti, C., Zanoboni, A., Massironi, R., Catalano, M., Cocchi, D., & Muller, E. E. (1989). Alpha2-adrenoceptor sensitivity in anorexia nervosa: GH response to clonidine or GHRH stimulation. Biological Psychiatry, 25, 256–264.PubMedGoogle Scholar
  23. Braunwald, E. (1983). Valvular heart disease. In R. D. Petersdorf, H. E. Adams, E. Braunwald, K. J. Isselbacher, J. B. Martin, & J. D. Wilson (Eds.), Harrison’s principles of internal medicine (10th ed., pp. 1402–1417). New York: McGraw-Hill.Google Scholar
  24. Briley, M. S., Langer, S. Z., Raizman, R., Sechter, D., & Zarifian, E. (1980). Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients. Science, 209, 303–305.PubMedGoogle Scholar
  25. Butler, J., & Leonard, B. E. (1988). The platelet serotonergic system in depression and following sertraline treatment. International Clinical Psychopharmacology, 3, 343–347.PubMedGoogle Scholar
  26. Campbell, I. C. (1981). Blood platelets in psychiatry. British Journal of Psychiatry, 138, 78–80.PubMedGoogle Scholar
  27. Carroll, B. J., Curtis, G. C., & Mendels, J. (1976). Neuroendocrine regulation in depression. II. Archives of General Psychiatry, 33, 1051–1058.PubMedGoogle Scholar
  28. Checkley, S. A., Slade, A. P., & Shur, E. (1981). Growth hormone and other responses to clonidine in patients with endogenous depression. British Journal of Psychiatry, 138, 51–55.PubMedGoogle Scholar
  29. Cleghorn, J. M., Garnett, E. S., Nahmias, C., Firnau, G., Brown, G. M., Kaplan, R., Szechtman, H., & Szechtman, B. (1989). Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia. Psychiatry Research, 28, 119–133.PubMedGoogle Scholar
  30. Coccaro, E. F., Siever, L. J., Klar, H. M., Maurer, G., Cochrane, K., Cooper, T. B., Mohs, R. C., & Davis, K. L. (1989). Serotonergic studies in patients with affective and personality disorders. Archives of General Psychiatry, 46, 587–599.PubMedGoogle Scholar
  31. Coffee, R. G., & Hadden, J. W. (1985). Neurotransmitters, hormones, and cyclic nucleotides in lymphocyte regulation. Federation of American Societies for Experimental Biology Proceedings, 44, 112–117.Google Scholar
  32. Cohen, R. M., Semple, W. E., & Gross, M. G. (1986). Positron emission tomography. Psychiatric Clinics of North America, 9, 63–79.PubMedGoogle Scholar
  33. Cook, B. L., Shukla, S., & Hoff, A.L. (1986). EEG abnormalities in bipolar affective disorder. Journal of Affective Disorders, 11, 147–149.PubMedGoogle Scholar
  34. Coppen, A., Swade, C., & Wood, K. (1980). Lithium restores abnormal platelet 5-HT transport in patients with affective disorders. British Journal of Psychiatry, 136, 235–238.PubMedGoogle Scholar
  35. Coppen, A. J., & Doogan, D. P. (1988). Serotonin and its place in the pathogenesis of depression. Journal of Clinical Psychiatry, 49, 4s–11s.Google Scholar
  36. Coryell, W. (1984). The use of laboratory tests in psychiatric diagnosis: The DST as an example. Psychiatric Development, 3, 139–159.Google Scholar
  37. Coryell, W. (1988). Secondary depression. In J. O. Cavenar, Jr. (Ed.), Psychiatry (pp. 1–9). Philadelphia: J. B. Lippencott.Google Scholar
  38. Coryell, W., Gaffney, G., & Burkhardt, P E. (1982). The dexamethasone suppression test and familial subtypes of depression—a naturalistic replication. Biological Psychiatry, 17, 33–39.PubMedGoogle Scholar
  39. Cowen, P. J., Geaney, D. P., Schachter, M., Green, A. R., & Elliot, J. M. (1984). Desipramine treatment in normal subjects. Archives of General Psychiatry, 43, 61–67.Google Scholar
  40. Cowley, D. S., Dager, S. R., & Dunner, D. L. (1986). Lactate-induced panic in primary affective disorder. American Journal of Psychiatry, 143, 646–648.PubMedGoogle Scholar
  41. Cowley, D. S., Dager, S. R., & Dunner, D. L., (1987). Lactate infusions in major depression without panic attacks. Journal of Psychiatric Research, 21, 243–248.PubMedGoogle Scholar
  42. Cowley, D. S., Hyde, T. S., Dager, S. R., & Dunner, D. L. (1987). Lactate infusions: The role of baseline anxiety. Psychiatry Research, 21, 169–179.PubMedGoogle Scholar
  43. Dager, S. R., Comess, K. A., Saal, A. K., Sisk, E. J., Beach, K. W., & Dunner, D. L. (1989). Diagnostic reliability of M-mode echocardiography for detecting mitral valve prolapse in 50 consecutive panic patients. Comprehensive Psychiatry, 30, 369–375.PubMedGoogle Scholar
  44. Davis, J. M., Koslow, S. H., Gibbons, R. D., Maas, J. W., Bowden, C. L., Casper, R., Hanin, I., Javaid, J. I., Chang, S. S., & Stokes, P E. (1988). Cerebrospinal fluid and urinary biogenic amines in depressed and healthy controls. Archives of General Psychiatry, 45, 705–717.PubMedGoogle Scholar
  45. DeLisi, L. E., Buchsbaum, M. S., Holcomb, H. H., Langston, K. C., King, A. C., Kessler, R., Pickar, D., Carpenter, W. T., Morihisa, J. M., Margolin, R. et al. (1989). Increased temporal lobe glucose use in chronic schizophrenic patients. Biological Psychiatry, 25, 835–851.PubMedGoogle Scholar
  46. Devereux, R. B., Kramer-Fox, R., & Shear, M. K. (1986). Prevalence of panic disorder in relatives [letter]. Psychosomatics, 27, 797.PubMedGoogle Scholar
  47. Diamond, I., Wrubel, B., Estrin, W., & Gordon, A. (1987). Basal and adenosine receptor-stimulated levels of cAMP are reduced in lymphocytes from alcoholic patients. Proceedings of the National Academy of Sciences of the United States of America, 84, 1413–1416.PubMedGoogle Scholar
  48. Dillon, D. J., Gorman, J. M., Liebowitz, M. R., Fyer, A. J., and Klein, D. F. (1987). Measurement of lactate-induced panic and anxiety. Psychiatry Research, 20, 97–105.PubMedGoogle Scholar
  49. Dorovini-Zis, K., & Zis, A. P. (1987). Increased adrenal weight in victims of violent suicide. American Journal of Psychiatry, 144, 1214–1215.PubMedGoogle Scholar
  50. Dupont, R. M., Jernigan, T. L., & Butters, N. (1990). Subcortical abnormalities detected in bipolar affective disorder using MRI. Archives of General Psychiatry, 47, 55–59.PubMedGoogle Scholar
  51. Eriksson, E., Balldin, J., Lindstedt, G., & Modigh, K. (1988). Growth hormone responses to the alpha2-adrenoceptor agonist guanfacine and to growth hormone releasing hormone in depressed patients and controls. Psychiatry Research, 26, 59–67.PubMedGoogle Scholar
  52. Extein, I., Tallman, J., Smith, C. C., & Goodwin, F. K. (1979). Changes in lymphocyte beta-adrenergic receptors in depression and mania. Psychiatry Research, 1, 191–197.PubMedGoogle Scholar
  53. Farde, L., Wiesel, F., Stone-Elander, S., Halldin, C., Nordstrom, A., Hall, H., & Sedvall, G. (1990). D2 dopamine receptors in neuroleptic-naive schizophrenic patients. Archives of General Psychiatry, 47, 213–219.PubMedGoogle Scholar
  54. Feighner, J. P., Robins, E., Guze, S. B., & Goodwin, F. K. (1972). Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.PubMedGoogle Scholar
  55. Fleissner, A., Seiffert, R., Schneider, K. et al. (1987). Platelet monoamine oxidase activity and schizophrenia—a myth that refuses to die? European Archives of Psychiatry and Neurology, 237, 8–15.Google Scholar
  56. Gaffney, F. A., Fenton, B. J., Lane, C. R., & Lake, C. R. (1988). Hemodynamic, ventilatory, and biochemical responses of panic patients and normal controls with sodium lactate infusion. Archives of General Psychiatry, 45, 53–60.PubMedGoogle Scholar
  57. Garcia-Sevilla, J. A., Zis, A. P., Hollingsworth, P. J., Greden, J. F., & Smith, C. B. (1981). Platelet alpha2-adrenergic receptors in major depressive disorder: Binding of tritiated clonidine before and after tricyclic antidepressant drug treatment. Archives of General Psychiatry, 38, 1327–1333.PubMedGoogle Scholar
  58. Garcia-Sevilla, J. A., Guimon, J., Garcia-Vallejo, P., & Fuster, M. J. (1986). Biochemical and functional evidence of supersensitive platelet alpha2-adrenoceptors in major affective disorder. Archives of General Psychiatry, 43, 51–57.PubMedGoogle Scholar
  59. George, D. T., Nutt, D. J., Waxman, R. P., & Linnoila, M. (1989). Panic response to lactate administration in alcoholic and nonalcoholic patients with panic disorder. American Journal of Psychiatry, 146, 1161–1165.PubMedGoogle Scholar
  60. Gibbons, R. D., & Davis, J. M. (1986). Consistent evidence for a biological subtype of depression characterized by low CSF 5-HIAA monoamine levels. Acta Psychiatrica Scandinavica, 74, 8–12.PubMedGoogle Scholar
  61. Giles, D. E., Roffwarg, H. P., Schlesser, M. A., & Rush, A. J. (1986). Which endogenous depressive symptoms relate to REM latency reduction? Biological Psychiatry, 21, 473–482.PubMedGoogle Scholar
  62. Giles, D. E., Roffwarg, H. P., & Rush, A. J. (1987). REM latency concordance in depressed family members. Biological Psychiatry, 22, 910–914.PubMedGoogle Scholar
  63. Giles, D. E., Schlesser, M. A., Rush, A. J., Orsulak, P. J., Fulton, C. L., & Roffwarg, H. P. (1987). Polysomnographic findings and dexamethasone nonsuppression in unipolar depression: A replication and extension. Biological Psychiatry, 22, 872–882.PubMedGoogle Scholar
  64. Giles, D. E., Kupfer, D. J., Roffwarg, H. P., Rush, A. J., Biggs, M. M., & Etzel, B. A. (1989). Polysomnographic parameters in first-degree relatives of unipolar probands. Psychiatry Research, 27, 127–136.PubMedGoogle Scholar
  65. Gillin, J. C., Duncan, W. C., Murphy, D. L., Post, R. M., Wehr, T. A., Goodwin, F. K., Wyatt, R. J., & Bunney, W. E., Jr. (1981). Age-related changes in sleep in depressed and normal subjects. Psychiatry Research, 4, 72–78.Google Scholar
  66. Gitlin, M., Weiner, H., Fairbanks, L. (1987). Failure of T3 to potentiate tricyclic antidepressant response. Journal of Affective Disorders, 13, 267–272.PubMedGoogle Scholar
  67. Gold, P. W., & Chrousos, G. P (1985). Clinical studies with corticotropin releasing factor: Implications for the diagnosis and pathophysiology of depression, Cushing’s disease, and adrenal insufficiency. Psychoneuroendocrinology, 10, 401–419.PubMedGoogle Scholar
  68. Goodwin, D. W (1986). Anxiety. New York: Oxford University Press.Google Scholar
  69. Gorman, J. M., Cohen, B. S., Liebowitz, M. R., Fyer, A. J., Ross, D., Davies, S. O., & Klein, D. F. (1986). Blood gas changes and hypophosphatemia in lactate-induced panic. Archives of General Psychiatry, 43, 1067–1071.PubMedGoogle Scholar
  70. Gorman, J. M., Goetz, R. R., Fyer, M., King, D. L., Fyer, A. J., Liebowitz, M. R., & Klein, D. F. (1988). The mitral valve prolapse connection. Psychosomatic Medicine, 50, 114–122.PubMedGoogle Scholar
  71. Gur, R. E., Mozley, P. D., Resnick, S. M., Shtasel, D., Kohn, M., Zimmerman, R., Herman, G., Atlas, S., Grossman, R., Erwin, R., & Gur, R. C. (1991). Magnetic resonance imaging in schizophrenia: I. Volumetric analysis of brain and cerebrospinal fluid. Archives of General Psychiatry, 48, 407–412.PubMedGoogle Scholar
  72. Halper, J. P., Brown, R. P., Sweeney, J. A., Kocsis, J. H., Peters, A., Mann, J. J. (1988). Blunted beta-adrenergic responsivity of peripheral blood mononuclear cells in endogenous depression. Archives of General Psychiatry, 45, 241–246.PubMedGoogle Scholar
  73. Hartman, N., Kramer, R., Brown, W. T., & Devereux, R. B. (1982). Panic disorder in patients with mitral valve prolapse. American Journal of Psychiatry, 139, 669–670.PubMedGoogle Scholar
  74. Henn, F. A. (1986). The neurobiologic basis of psychiatric illnesses. In G. Winokur & P. Clayton (Eds.), The medical basis of psychiatry (pp. 461–485). Philadelphia: W. B. Saunders.Google Scholar
  75. Hollander, E., Liebowitz, M. R., Cohen, B., Gorman, J. M., Fyer, A. J., Papp, L. A., & Klein, D. F. (1989). Prolactin and sodium lactate-induced panic. Psychiatry Research, 28, 181–191.PubMedGoogle Scholar
  76. Hollander, E., Liebowitz, M. R., Gorman, J. M., Cohen, B., Fyer, A., & Klein, D. F. (1989). Cortisol and sodium lactate-induced panic. Archives of General Psychiatry, 46, 135–140.PubMedGoogle Scholar
  77. Holzman, P. S., Proctor, L. R., & Hughes, D. W. (1973). Eye-tracking patterns in schizophrenia. Science, 181, 179–180.PubMedGoogle Scholar
  78. Holzman, P. S., Proctor, L. R., Levy, D. L., Yasillo, N. J., Meltzer, H. Y., & Hurt, S. W. (1974). Eye-tracking dysfunctions in schizophrenic patients and their relatives. Archives of General Psychiatry, 31, 143–151.PubMedGoogle Scholar
  79. Holzman, P. S., Levy, D. L., & Proctor, L. R. (1976). Smooth pursuit eye movements, attention and schizophrenia. Archives of General Psychiatry, 33, 1415–1420.PubMedGoogle Scholar
  80. Holzman, P. S., Kringlen, E., Levy, D. L., & Haberman, S. (1980). Deviant eye tracking in twins discordant for psychosis: A replication. Archives of General Psychiatry, 37, 627–631.PubMedGoogle Scholar
  81. Holzman, P. S., Kringlen, E., Matthysse, S., Flanagan, S. D., Lipton, R. B., Cramer, G., Levin, S., Lange, K., & Levy, D. L. (1988). A single dominant gene can account for eye tracking dysfunctions and schizophrenia in offspring of discordant twins. Archives of General Psychiatry, 45, 641–647.PubMedGoogle Scholar
  82. Hrdina, P. D. (1989). Imipramine binding sites in brain and platelets: Role in affective disorders. International Journal of Clinical Pharmacological Research, 9, 119–122.Google Scholar
  83. Ieni, J. R., Zukin, S. R., & Van Praag, H. M. (1984). Human platelets possess multiple [3H]-imipramine binding sites. European Journal of Pharmacology, 106, 669–672.PubMedGoogle Scholar
  84. Ivanovic, I. D., & Majkic-Singh, N. (1988). Determination of platelet monoamine oxidase by new continuous spectrophotometric method. Journal of Clinical Chemistry and Clinical Biochemistry, 26, 447–451.Google Scholar
  85. Jaeckle, R., Kathol, R. G., & Lopez, J. (1987). Enhanced adrenal sensitivity to exogenous cosyntropin stimulation in major depression. Archives of General Psychiatry, 44, 233–240.PubMedGoogle Scholar
  86. Janowsky, D. S., El-Yousef, M. K., & Davis, J. M. (1972). Cholinergic-adrenergic hypothesis of mania and depression. Lancet, 2, 632.PubMedGoogle Scholar
  87. Janowsky, D. S., Risch, S. C., Ziegler, M. G., Gillin, J. C., Huey, L., & Rausch, J. (1986). Physostigmine-induced epinephrine release in patients with affective disorder. American Journal of Psychiatry, 143, 919–921.PubMedGoogle Scholar
  88. John, E. R., Prichep, L. S., Fridman, J., & Easton, P. (1988). Neurometrics: computer-assisted differential diagnosis of brain dysfunctions. Science, 239, 162–169.PubMedGoogle Scholar
  89. Kafka, M. S., & Paul, S. (1986). Platelet alpha2-adrenergic receptors in depression. Archives of General Psychiatry, 43, 91–95.PubMedGoogle Scholar
  90. Kasper, S., & Beckman, H. (1983). Dexamethasone suppression test in a pluridiagnostic approach: Its relationship to psychopathological and clinical variables. Acta Psychiatrica Scandinavica, 68, 31–37.PubMedGoogle Scholar
  91. Kathol, R. G. (1985a). Circadian rhythm and peak frequency of corticosteroid excretion: Relationship to affective disorder. Psychiatry Medicine, 3, 53–63.Google Scholar
  92. Kathol, R. G. (1985b). Persistent elevation of urinary free cortisol and loss of circannual periodicity in recovered depressive patients. Journal of Affective Disorders, 8, 137–145.PubMedGoogle Scholar
  93. Kathol, R. G., Jaeckle, R. S., Lopez, J. F., & Meiler, W. H. (1989). Pathophysiology of HPA axis abnormalities in patients with major depression: An update. American Journal of Psychiatry, 146, 311–317.PubMedGoogle Scholar
  94. Kemali, D., DelVecchio, M., & Maj, M. (1982). Increased noradrenaline levels in CSF and plasma of schizophrenics. Biological Psychiatry, 17, 711–717.PubMedGoogle Scholar
  95. Kemali, D., Maj, M., Galderisi, S., Salvati, A., Starace, F., Valente, A., & Pirozzi, R. (1987). Clinical, biological, and neuropsychological features associated with lateral ventricular enlargement in DSM-III schizophrenic disorder. Psychiatry Research, 21, 137–149.PubMedGoogle Scholar
  96. Kirkegaard, C., & Carroll, B. J. (1980). Dissociation of TSH and adrenocortical disturbances in endogenous depression. Psychiatry Research, 3, 253–264.PubMedGoogle Scholar
  97. Kirkegaard, C., Norlein, N., Lauridsen, U. B., Bjorum, N., & Christiansen, C. (1975). Protirelin stimulation test and thyroid function during treatment of depression. Archives of General sychiatry, 32, 1115–1118.Google Scholar
  98. Kupfer, D. J., & Foster, F. G. (1972). Interval between onset of sleep and rapid eye movement sleep as an indicator of depression. Lancet, 11, 684–686.Google Scholar
  99. Kupfer, D. J., Foster, F. G., Coble, P. et al. (1978). The application of EEG sleep for the differential diagnosis of affective disorders. American Journal of Psychiatry, 135, 69–74.PubMedGoogle Scholar
  100. Lake, C. R., Sternberg, D. E., van Kammen, D. P., Ballenger, J. C., Ziegler, M. G., Post, R.M., Kopin, I. J., & Bunney, W. E. (1980). Schizophrenia: Elevated cerebrospinal fluid norepinephrine. Science, 207, 331–333.PubMedGoogle Scholar
  101. Langer, S. Z., Sechter, D., Loo, H., Raisman, R., & Zarifian, E. (1986). Electroconvulsive shock therapy and maximum binding of platelet tritiated imipramine binding in depression. Archives of General Psychiatry, 43, 949–952.PubMedGoogle Scholar
  102. Langer, S. Z., Galzin, A. M., Poirier, M. F., Loo, H., Sechter, D., & Zarifian, E. (1987). Association of 3H-imipramine and 3H-paroxetine binding with the 5HT transporter in brain and platelets: Relevance to studies in depression. Journal of Receptor Research, 7, 499–521.PubMedGoogle Scholar
  103. Lauer, C., Zulley, J., Krieg, J. C., Riemann, D., & Berger, M. (1988). EEG and thee cholinergic REM induction test in anorexic and bulimic patients. Psychiatry Research, 26, 171–181.PubMedGoogle Scholar
  104. Lesch, K. P., Muller, U., Kruse, K., & Schulte, H. M. (1989). Endocrine responses to growth hormone-releasing hormone, thyrotropin-releasing hormone and corticotropin-releasing hormone in depression. Acta Psychiatrica Scandinavica, 79, 597–602.PubMedGoogle Scholar
  105. Levy, D. L., Yasillo, N. J., Dorus, E., Shaughnessy, R., Gibbons, R. D., Peterson, J., Janicak, R G., Gaviria, M., & Davis, J. M. (1983). Relatives of unipolar and bipolar patients have normal pursuit. Psychiatry Research, 10, 285–293.PubMedGoogle Scholar
  106. Lewis, D. A., & McChesney, C. (1985). Tritiated imipramine binding distinguishes between subtypes of depression. Archives of General Psychiatry, 42, 485–488.PubMedGoogle Scholar
  107. Lewis, D. A., Noyes, R., Coryell, W., & Clancy, J. (1985). Tritiated imipramine binding to platelets is decreased in patients with agoraphobia. Psychiatry Research, 16, 1–9.PubMedGoogle Scholar
  108. Lieber, A. L., & Newbury, N. D. (1988a). Diagnosis and subtyping of depressive disorders by quantitative electroencephalography: III. Discriminating unipolar from bipolar depression. Hillside Journal of Clinical Psychiatry, 10, 165–172.PubMedGoogle Scholar
  109. Lieber, A. L., & Newbury, N. D. (1988b). Diagnosis and subtyping of depressive disorders by quantitative electroencephalography: IV Discriminating subtypes of unipolar depression. Hillside Journal of Clinical Psychiatry, 10, 173–182.PubMedGoogle Scholar
  110. Liebowitz, M. R., Gorman, J. M., Fyer, A., Dillon, D., Levitt, M., & Klein, D. F. (1986). Possible mechanisms for lactate’s induction of panic. American Journal of Psychiatry, 143, 495–500.PubMedGoogle Scholar
  111. Lingjaerde, O. (1983). Serotonin uptake and efflux in blood platelets from untreated and neuroleptic-treated schizophrenics. Biological Psychiatry, 18, 1345–1356.PubMedGoogle Scholar
  112. Loosen, P. T., Wilson, J. C., Dew, B. W. et al. (1979). Thyrotropin-releasing hormone (TRH) in abstinent alcoholic men. American Journal of Psychiatry, 136, 540–547.Google Scholar
  113. Loosen, P. T., Prange, A. J., Jr., & Wilson, J. C. (1983). TRH (Protirelin) in depressed alcoholic men: Behavioral and endocrine response. American Journal of Psychiatry, 140, 1145–1149.PubMedGoogle Scholar
  114. Lopez, J., Kathol, R. G., & Jaeckle, R. S. (1987). The HPA axis response to insulin hypoglycemia in depression. Biological Psychiatry, 22, 153–166.PubMedGoogle Scholar
  115. Maas, J. W., Koslow, S. H., Davis, J., Katz, M., Frazer, A., Bowden, C. L., Berman, N., Gibbons, R., Stokes, P., & Landis, H. (1987). Catecholamine metabolism and disposition in healthy subjects. Archives of General Psychiatry, 44, 337–344.PubMedGoogle Scholar
  116. Maj, M., Arena, F., Galderisi, S., Starace, F., & Kemali, D. (1987). Factors associated with decreased platelet MAO activity in chronic schizophrenics. Progress in Neuropsychopharmacology and Biological Psychiatry, 11, 79–86.Google Scholar
  117. Mann, J. J., Brown, R. P., Halper, J. P., Sweeney, J. A., Kocsis, J. H., Stokes, P. E., & Bilezikian, J. P. (1985). Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation. New England Journal of Medicine, 313, 715–720.PubMedGoogle Scholar
  118. Mann, J. J., Kaplan, R. D., & Bird, E. D. (1986). Elevated postmortem monoamine oxidase B activity in the caudate nucleus of Huntington’s disease compared to schizophrenics and controls. Journal of Neural Transmission, 65, 277–283.PubMedGoogle Scholar
  119. Matussek, N., Ackenheil, M., Hippius, H., Muller, F., Schroder, H., Schultes, H., & Wasilewski, B. (1980). Effect of clonidine on growth hormone release in psychiatric patients and controls. Psychiatry Research, 2, 25–36.PubMedGoogle Scholar
  120. Meltzer, H. Y., & Zureick, J. K. (1987). Relationship of auditory hallucinations and paranoia to platelet MAO activity in schizophrenics: Sex and race interactions. Psychiatry Research, 11, 79–86.Google Scholar
  121. Meltzer, H. Y., & Aurora, R. C. (1988). Genetic control of serotonin uptake in blood platelets: A twin study. Psychiatry Research, 24, 263–269.PubMedGoogle Scholar
  122. Meltzer, H. Y., Aurora, R. C., Baber, R., & Tricou, B. J. (1981). Serotonin uptake in blood platelets of psychiatry. Archives of General Psychiatry, 38, 1322–1326.PubMedGoogle Scholar
  123. Mitchell, P. B., Beam, J. A., Corn, T. H., & Checkley, S. A. (1988). Growth hormone response to clonidine after recovery in patients with endogenous depression. British Journal of Psychiatry, 152, 34–38.PubMedGoogle Scholar
  124. Muller, N., Hoehe, M., Klein, H. E., Nieberle, G., Kapfhammer, H. P., May, F., Muller, O A., & Fichter, M. (1989). Endocrinological studies in alcoholics during withdrawal and after abstinence. Psychoneuroendocrinology, 14, 113–123.PubMedGoogle Scholar
  125. Nemeroff, C. B., Owens, M. J., Bissette, G., Andorn, A. C., & Stanley, M. (1988). Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Archives of General Psychiatry, 45, 577–580.PubMedGoogle Scholar
  126. Okasha, A., & Madikur, O. (1982). Cortical and central atrophy in chronic schizophrenia: A controlled study. Acta Psychiatrica Scandinavica, 65, 29–34.PubMedGoogle Scholar
  127. Overstreet, D. H., Janowsky, D. S., & Rezvani, A. H. (1989). Alcoholism and depressive disorders: Is cholinergic sensitivity a biological marker? Alcohol, 24, 253–255.Google Scholar
  128. Owen, F., Crow, T. J., Frith, C. D., Johnsson, J. A., Johnstone, E. C., Lofhouse, R., Owens, G. C., & Poulter, M. (1987). Selective decreases in MAO-B activity in postmortem brains from schizophrenic patients with type II syndrome. British Journal of Psychiatry, 151, 514–519.PubMedGoogle Scholar
  129. Pandey, G. N., Janicak, P. G., Javaid, J. I., & Davis, J. M. (1989). Increased 3H-clonidine binding in the platelets of patients with depressive and schizophrenic disorders. Psychiatry Research, 28, 73–88.PubMedGoogle Scholar
  130. Pandurangi, A. K., Dewan, M. J., & Boucher, M. (1986). A comprehensive study of schizophrenic patients: II. biological, neuropsychological, and clinical correlates of CT abnormality. Acta Psychiatrica Scandinavica, 73, 161–171.PubMedGoogle Scholar
  131. Pfefferbaum, A., Zipursky, R. B., Lim, K. O., Katz, L. M., Stahl, S. M., & Jernigan, T. L. (1988). Computed tomographic evidence for generalized sulcal and ventricular enlargement in schizophrenia. Archives of General Psychiatry, 45, 633–640.PubMedGoogle Scholar
  132. Pitts, F. N., & McClure, J. N. (1967). Lactate metabolism in anxiety neurosis. New England Journal of Medicine, 277, 1329–1336.PubMedGoogle Scholar
  133. Pletscher, A. (1968). Metabolism transfer and storage of 5HT in blood platelets. British Journal of Pharmacology, 32, 1–16.Google Scholar
  134. Potkin, S. G., Weinberger, D. R., Linnoila, M., & Wyatt, R. J. (1983). Low CSF 5-HIAA in schizophrenic patients with enlarged cerebral ventricles. American Journal of Psychiatry, 140, 21–25.PubMedGoogle Scholar
  135. Prang, A. J., Wilson, I. C., Lara, P. P., Alltop, L. B., & Breese, G. R. (1972). Effects of thyrotropin releasing hormone in depression. Lancet, 11, 999.Google Scholar
  136. Quitana, J. (1989). Platelet serotonin uptake dynamic changes in depression: Effects of long-term imipramine treatment and clinical recovery. Journal of Affective Disorders, 16, 233–242.Google Scholar
  137. Raichle, M. E., Grubb, R. L., Gado, M. H., Eichling, J. O., & Ter-Pogossian, M. P. (1976). Correlation between regional cerebral blood flow and oxidative metabolism. Archives of Neurology, 8, 523–526.Google Scholar
  138. Rausch, J. L., Janowsky, D. S., Risch, S. C., & Huey, L. Y. (1986). A kinetic analysis and replication of decreased platelet serotonin uptake in depressed patients. Psychiatry Research, 19, 105–112.PubMedGoogle Scholar
  139. Rausch, J. L., Rich, C. L., & Risch, S. C. (1988). Platelet serotonin transport after a single ECT. Psychopharmacology, 95, 139–141.PubMedGoogle Scholar
  140. Reveley, M. A., Glover, V., Sandier, M., & Spokes, E. G. (1981). Brain monoamine oxidase activity in schizophrenics and controls. Archives of General Psychiatry, 38, 663–665.PubMedGoogle Scholar
  141. Reynolds, C. E., & Kupfer, D. J. (1987). Sleep research in affective illness: State-of-the-art circa 1987. Sleep, 10, 199–215.PubMedGoogle Scholar
  142. Reynolds, C. F., Kupfer, D. J., & Taska, L. S. (1985). EEG sleep in healthy elderly, depressed, and demented subjects. Biological Psychiatry, 20, 431–442.PubMedGoogle Scholar
  143. Rieder, R. O., Mann, L. S., Weinberger, D. R., van Kammen, D. P., & Post, R. M. (1983). Computed tomographic scans in patients with schizophrenia, schizoaffective disorder, and bipolar disorder. Archives of General Psychiatry, 40, 735–739.PubMedGoogle Scholar
  144. Riemann, D., & Berger, M. (1989). EEG sleep in depression and in remission and the REM sleep response to the cholinergic agonist RS-86. Neuropsychopharmacology, 2, 145–152.PubMedGoogle Scholar
  145. Rose, R. M., Castellani, S., Boeringa, J. A., Boeringa, A., Malek-Ahmadi, P., Lankford, A., Bessman, J. D., Fritz, R. R., Denney, C. B., Denney, R. M., & Abell, C. W. (1986). Platelet MAO concentration and molecular activity: II. Comparison of normal and schizophrenic populations. Psychiatry Research, 17, 141–151.PubMedGoogle Scholar
  146. Rosenberg, R., Vostrup, S., Andersen, A., & Bolwig, T. (1988). Effect of ECT on cerebral blood flow in melancholia assessed with SPECT. Convulsive Therapy, 4, 62–73.PubMedGoogle Scholar
  147. Roy, A., Jimmerson, D. C., Pickar, D., (1986). Plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) in depressive disorders: Relationship to the dexamethasone suppression test. American Journal of Psychiatry, 143, 846–851.PubMedGoogle Scholar
  148. Roy, A., Pickar, D., DeJong, J., Karoum, F., & Linnoila, M. (1988). Norepinephrine and its metabolites in cerebrospinal fluid, plasma, and urine: Relationship to hypothalamic-pituitary-adrenal axis function in depression. Archives of General Psychiatry, 45, 849–857.PubMedGoogle Scholar
  149. Roy, A., Dejong, J., & Linnoila, M. (1989). Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients: A five-year follow-up study. Archives of General Psychiatry, 46, 609–612.PubMedGoogle Scholar
  150. Rush, A. J., Giles, D. E., Roffwarg, H. E., & Parker, C. R. (1982). Sleep EEG and dexamethasone suppression test findings in outpatients with unipolar major depressive disorders. Biological Psychiatry, 17, 327–341.PubMedGoogle Scholar
  151. Rush, A. J., Erman, M. K., Giles, D. E., Schlesser, M. A., Carpenter, M. A., Vasavada, N., & Roffwarg, H. P (1986). Polysomnographic findings in recently drug-free and clinically remitted depressed patients. Archives of General Psychiatry, 43, 878–884.PubMedGoogle Scholar
  152. Sackeim, H. A., Prohovnik, I., Moeller, J. R., Brown, R. P., Apter, S., Prudic, J., Devanand D. P., & Mukherjee, S. (1990). Regional cerebral blood flow in mood disorders. Archives of General Psychiatry, 47, 60–70.PubMedGoogle Scholar
  153. Sanderson, W. C., Rapee, R. M., & Barlow, D. H. (1989). The influence of an illusion of control on panic attacks induced via inhalation of 5.5% carbon dioxide-enriched air. Archives of General Psychiatry, 46, 157–164.PubMedGoogle Scholar
  154. Schlesser, M. A., Winokur, G., & Sherman, B. M. (1980). Hypothalamic-pituitary-adrenal axis activity in depressive illness. Archives of General Psychiatry, 37, 737–743.PubMedGoogle Scholar
  155. Schneider, L. S. (1990). Biological markers in geriatric depression. Psychiatric Annals, 20, 83–91.Google Scholar
  156. Schneider, L. S., Fredrickson, E., Severson, J., & Sloan, R. B. (1986). 3H-imipramine binding in depressed elderly: Relationship to family history and clinical response. Psychiatry Research, 19, 257–266.PubMedGoogle Scholar
  157. Schuckit, M. A. (1984). Subjective responses to alcohol in sons of alcoholics and controls. Archives of General Psychiatry, 41, 879–884.PubMedGoogle Scholar
  158. Schuckit, M. A., & Gold, E. O. (1988). A simultaneous evaluation of multiple markers of ethanol/placebo challenges in sons of alcoholics and controls. Archives of General Psychiatry, 45, 211–216.PubMedGoogle Scholar
  159. Schuckit, M. A., Gold, E., & Risch, C. (1987). Plasma cortisol levels following ethanol in sons of alcoholics and controls. Archives of General Psychiatry, 44, 942–945.PubMedGoogle Scholar
  160. Schulsinger, F., Parnas, J., Petersen, E. T., Schulsinger, H. T., Teasdale, T. W., Mednick, S. A., Moller, L., & Silverton, L. (1984). Cerebral ventricular size in the offspring of schizophrenic mothers. Archives of General Psychiatry, 41, 602–606.PubMedGoogle Scholar
  161. Schwartz, J. M., Baxter, L. R., Mazziotta, J. C., Gerner, R. H., & Phelps, M. E. (1987). The differential diagnosis of depression: Relevance of positron emission tomography studies of cerebral glucose metabolism to the bipolar-unipolar dichotomy. Journal of the American Medical Association, 258, 1368–1374.PubMedGoogle Scholar
  162. Sevy, S., Papadimitriou, G. N., Surmont, D. W., Goldman, S., & Mendlewicz, J. (1989). Noradrenergic function in generalized anxiety disorder, major depressive disorder, and healthy subjects. Biological Psychiatry, 25, 141–152.PubMedGoogle Scholar
  163. Shaw, D. M., Camps, F. E., & Eccleston, E. G. (1967). 5-hydroxytryptamine in the hindbrain of depressive suicides. British Journal of Psychiatry, 113, 1407–1411.PubMedGoogle Scholar
  164. Shagass, C., Amadeo, M., & Overton, D. A. (1974). Eye-tracking performance in psychiatric patients. Biological Psychiatry, 9, 245–260.PubMedGoogle Scholar
  165. Shibuya, A., & Yoshida, A. (1988a). Frequency of the atypical aldehyde dehydrogenase-2 gene in Japanese and Caucasians. American Journal of Human Genetics, 43, 741–743.PubMedGoogle Scholar
  166. Shibuya, A., & Yoshida, A. (1988b). Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type, aldehydedehydrogenase gene (ALD1/2) with the disease. American Journal of Human Genetics, 43, 744–748.PubMedGoogle Scholar
  167. Siever, L. J., & Uhde, T. W. (1985). New studies and perspectives on the noradrenergic receptor system in depression: Effects of the alph-2-adrenergic agonist clonidine. Biological Psychiatry, 19, 131–156.Google Scholar
  168. Siever, L. J., Uhde, T. W., Jimmerson, D. C., Post, R. M., Lake, C. R., & Murphy, D. L. (1984). Plasma cortisol responses to clonidine in depressed patients and controls. Archives of General Psychiatry, 41, 63–68.PubMedGoogle Scholar
  169. Silfverskiold, P., & Risberg, J. (1989). Regional cerebral blood flow in depression and mania. Archives of General Psychiatry, 46, 253–259.PubMedGoogle Scholar
  170. Sitaram, N., Nurnberger, J. I., Jr., Gershon, E. S., & Gillin, J. C. (1980). Faster cholinergic REM sleep induction in euthymic patients with primary affective illness. Science, 208, 200–202.PubMedGoogle Scholar
  171. Sitaram, N., Nurnberger, J. I., Jr., Gershon, E. S., & Gillin, J. C. (1982). Cholinergic regulation of mood and REM sleep: Potential model and marker of vulnerability to affective disorder. American Journal of Psychiatry, 139, 571–576.PubMedGoogle Scholar
  172. Sitaram, N., Dube, S., Jones, D., Bell, J., Gurevich, D., & Gershon, E. S. (1984). Cholinergic REM-induction response as a state and possible genetic vulnerability marker of depression. Clinical Neuropharmacology, 7, 966–967.Google Scholar
  173. Slotkin, T. A., Whitmore, W. L., & Barnes, S. A. (1989). Reduced inhibitory effect of imipramine on radiolabeled serotonin uptake into platelets in geriatric depression. Biological Psychiatry, 25, 687–689.PubMedGoogle Scholar
  174. Sneddon, J. M. (1973). Blood platelets as a model for monoamine-containing neurones. Progress in Neurobiology, 1, 151–187.PubMedGoogle Scholar
  175. Spohn, H. E., Coyne, L., & Spray, J. (1988). The effect of neuroleptics and tardive dyskinesia on smooth-pursuit eye movement in chronic schizophrenics. Archives of General Psychiatry, 45, 833–840.PubMedGoogle Scholar
  176. Stahl, S. M. (1977). The human platelet. Archives of General Psychiatry, 34, 509–516.PubMedGoogle Scholar
  177. Stahl, S. M., & Meltzer, H. Y. (1978). A kinetic and pharmacologic analysis of 5-hydroxytryptamine transport by human platelets and platelet storage granules: Comparison with central serotonergic neurones. Journal of Pharmacological Experimental Therapy, 205, 118–132.Google Scholar
  178. Steiger, A., von Bardeleben, U., Herth, T., & Holsboer, F. (1989). Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery. Journal of Affective Disorders, 16, 189–195.PubMedGoogle Scholar
  179. Strom-Olsen, R., & Weil-Malherbe, H. (1964). Humoral changes in manic-depressive psychosis with particular reference to the excretion of catecholamines in urine. Journal of Mental Science, 104, 696–704.Google Scholar
  180. Swartz, C. M., Drews, V., & Cadoret, R. (1987). Decreased epinephrine in familial alcoholism. Archives of General Psychiatry, 44, 938–941.PubMedGoogle Scholar
  181. Tabekoff, B., Hoffman, P. L., Lee, J. M., Saito, T., Willard, B., & Leon-Jones, F. D. (1988). Differences in platelet enzyme activity between alcoholics and controls. New England Journal of Medicine, 318, 134–139.Google Scholar
  182. Takeda, T., Harada, T., & Otsuki, S. (1989). Platelet 3H-clonidine and 3H-imipramine binding and plasma cortisol level in depression. Biological Psychiatry, 26, 52–60.PubMedGoogle Scholar
  183. Targum, F. D., Greenberg, R. D. Harmon, R. H., Kessler, K., Salerian, A. J., & Fram, D. H. (1984). Thyroid hormone and TRH stimulation in refractory depression. Journal of Clinical Psychiatry, 45, 345–346.PubMedGoogle Scholar
  184. Thomas, R., Beer, R., Harris, B., John, R., & Scanlon, M. (1989). GH responses to growth hormone releasing factor in depression. Journal of Affective Disorders, 16, 133–137.PubMedGoogle Scholar
  185. Tilders, F. J. H., Berkenbosch, F. & Smelik, P G. (1982). Adrenergic mechanisms involved in the control of pituitary-adrenal activity in the rat: A beta-adrenergic stimulatory mechanism. Endocrinology, 110, 114–120.PubMedGoogle Scholar
  186. Uhde, T. W., Vittone, B. J., Siever, L. J., Kaye, W. H., & Post, R. M. (1986). Blunted growth hormone response to clonidine in panic disorder patients. Biological Psychiatry, 21, 1077–1081.Google Scholar
  187. vandenBosch, R., & Rozendaal, N. (1988). Subjective cognitive dysfunction, eye tracking, and slow brain potentials in schizophrenia and schizoaffective patients. Biological Psychiatry, 24, 741–746.Google Scholar
  188. van Kammen, D. P., Peters, J., & van Kammen, W. B. (1986). Cerebrospinal fluid studies of monoamine metabolism in schizophrenia. Psychiatric Clinics of North America, 9, 81–97.PubMedGoogle Scholar
  189. van Kammen, D. P., Peters, J., van Kammen, W. B., Nugent, A., Goetz, K. L., Yao, J., & Linnoila, M. (1989). CSF norepinephrine in schizophrenia is elevated prior to relapse after haloperidol withdrawal. Biological Psychiatry, 26, 176–188.PubMedGoogle Scholar
  190. Wagner, A., Aberg-Wistedt, A., Asberg, M., Ekqvist, B., Martensson, B., & Montero, D. (1985). Lower 3H-imipramine binding in platelets from untreated depressed patients compared to healthy controls. Psychiatry Research, 16, 131–139.PubMedGoogle Scholar
  191. Wagner, A., Aberg-Wistedt, A., Asberg, M., Bertilsson, L., Martensson, B., & Montero, D. (1987). Effects of antidepressant treatments on platelet tritiated imipramine binding in major depressive disorder. Archives of General Psychiatry, 44, 870–877.PubMedGoogle Scholar
  192. Wallach, J. (1986). Interpretations of diagnostic tests (pp. 644–646). Boston: Little, Brown.Google Scholar
  193. Webb, W. B., & Campbell, S. C. (1983). Relationships in sleep characteristics of identical and fraternal twins. Archives of General Psychiatry, 40, 1093–1095.PubMedGoogle Scholar
  194. Weinberger, D. R., Bigelow, L. B. Klein, S. T., Rosenblatt, J. E., & Wyatt, R. J. (1980). Cerebral ventricular enlargement in chronic schizophrenia: An association with poor response to therapy. Archives of General Psychiatry, 37, 11–13.PubMedGoogle Scholar
  195. Weizman, A., Carmi, M., Hermesh, H., Shahar, A., Apter, A., Tyano, S., & Rehavi, M. (1986). High-affinity imipramine binding and serotonin uptake in platelets of eight adolescent and ten adult obsessive-compulsive patients. American Journal of Psychiatry, 143, 335–339.PubMedGoogle Scholar
  196. Winokur, G., Behar, D., Van Valkenburg, C., & Lowry, M. (1978). Is a familial definition of depression both feasible and valid? Journal of Nervous and Mental Disease, 166, 764–768.PubMedGoogle Scholar
  197. Winokur, G., Black, D. W., & Nasrallah, A. (1987). DST nonsuppressor status: Relationship to specific aspects of the depressive syndrome. Biological Psychiatry, 22, 360–368.PubMedGoogle Scholar
  198. Wolfe, N., Gelenberg, A. J., & Lydiard, R. B. (1989). Alpha2-adrenergic receptor sensitivity in depressed patients: Relation between 3H-yohimbine binding to platelet membranes and clonidine-induced hypotension. Biological Psychiatry, 25, 382–392.PubMedGoogle Scholar
  199. Wyatt, R. J., Potkin, S. G., & Murphy, D. L. (1979). Platelet monoamine oxidase activity in schizophrenia: A review of the data. American Journal of Psychiatry, 136, 377–385.PubMedGoogle Scholar
  200. Zec, R. E., & Weinberger, D. R. (1986). Relationship between CT scan findings and neuropsychological performance in chronic schizophrenia. Psychiatric Clinics of North America, 9, 49–62.PubMedGoogle Scholar
  201. Zemishlany, Z., Modai, I., Apter, A., Jerushalmi, Z., Samuel, E., & Tyano, S. (1987). Serotonin uptake by blood platelets in anorexia nervosa. Acta Psychiatrica Scandinavica, 75, 127–130.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Stephen D. Samuelson
    • 1
  • George Winokur
    • 2
  1. 1.Department of PsychiatryThe University of Texas Health Science Center at San AntonioSan AntonioUSA
  2. 2.Department of Psychiatry, College of MedicineUniversity of IowaIowa CityUSA

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