Psychoactive Drugs in the Psychotic and Affective Disorders

  • Alice Medalia
  • James Gold
Part of the Critical Issues in Neuropsychology book series (CINP)


The neuropsychological assessment of psychiatric patients is often complicated by the medications or treatments that are being administered. The clinician must discern whether impaired test performance reflects disease-related or iatrogenically induced cognitive deficit. In this chapter we review the literature investigating the effects of neuroleptics, antidepressants, and lithium on the neuropsychological test performance of psychiatric patients. For a review of the cognitive effects of these medications in normal subjects we refer the reader to Judd, Squire, Butters, Salmon, and Palier (1987). This review focuses on measures that are commonly used in the context of neuropsychological assessment. It is organized by medication and particular cognitive function or test that might be affected. At the end of each section we propose some clinical guidelines and theoretical hypotheses that can be generated on the basis of this literature.


Schizophrenic Patient Psychoactive Drug Bipolar Patient Digit Symbol Chronic Schizophrenia 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Alice Medalia
    • 1
  • James Gold
    • 2
  1. 1.Departments of Psychiatry and Neurology, Albert Einstein College of MedicineBronx Municipal Hospital CenterBronxUSA
  2. 2.Department of PsychologyNational Institute of Mental Health, St. Elizabeths HospitalUSA

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