Abstract
The conceptualization of schizophrenia as a brain disorder is long-standing. Kraepelin (1919/1971) emphasized the gradual cognitive deterioration in schizophrenia and argued that this “dementia” was organically based. Although Bleuler (1950) viewed “associative disturbance” as the core symptom in schizophrenia, like Kraepelin he presumed the symptoms of schizophrenia were a manifestation of underlying organic impairment. Since the times of Kraepelin and Bleuler, interest in organic determinants of schizophrenia has waxed and waned. Most recently, we have entered a new era of biological research on the disorder. The renewed concern with biological factors was, in part, spawned by the increasing sophistication of available techniques for assessing brain structure and function.
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Walker, E., Lucas, M., Lewine, R. (1992). Schizophrenic Disorders. In: Puente, A.E., McCaffrey, R.J. (eds) Handbook of Neuropsychological Assessment. Critical Issues in Neuropsychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0682-3_11
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