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Flexibility of Globular Proteins in Water as Revealed by Compressibility

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Book cover Water Relationships in Foods

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 302))

Abstract

In order to elucidate the flexibility-structure-function relationships of proteins, the adiabatic compressibility of about 30 globular proteins, including food proteins, was determined by means of sound velocity and density measurements in aqueous solutions. Most proteins studied showed positive compressibility, indicating the large internal flexibility of the molecules. The volume fluctuation was in the range of 30–200 ml/mol, which corresponded to about 0.3% of the total protein volume. From the statistical analyses of the compressibility data, it was found that the flexibility of proteins is closely related to structural factors such as hydrophobicity, helix element, and amino acid composition, and to functional properties such as digestibility and foaming capacity. These results indicate that the dynamics of protein structure should be taken into account in predicting precisely the functions and properties of a protein from its primary or tertiary structure.

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Authors and Affiliations

  1. Department of Food Science and Technology, Faculty of Agriculture, Nagoya University, Nagoya 464, Japan

    Kunihiko Gekko

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  1. Kunihiko Gekko
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Editors and Affiliations

  1. Fundamental Science Group, Nabisco Brands, Inc., P.O. 1943, 200 DeForest Ave., East Hanover, NJ, 07936, USA

    Harry Levine (Senior Principal Scientist) & Louise Slade (Research Fellow) (Senior Principal Scientist) &  (Research Fellow)

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© 1991 Springer Science+Business Media New York

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Gekko, K. (1991). Flexibility of Globular Proteins in Water as Revealed by Compressibility. In: Levine, H., Slade, L. (eds) Water Relationships in Foods. Advances in Experimental Medicine and Biology, vol 302. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0664-9_42

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  • DOI: https://doi.org/10.1007/978-1-4899-0664-9_42

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0666-3

  • Online ISBN: 978-1-4899-0664-9

  • eBook Packages: Springer Book Archive

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