Mechanism of Misoprostol Stabilization in Hydroxypropyl Methylcellulose

  • Tugrul T. Kararli
  • Thomas Catalano
  • Thomas E. Needham
  • Pat M. Finnegan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 302)

Abstract

The stability of misoprostol oil is significantly improved in a hydroxypropyl methylcellulose (HPMC) dispersion (1:100).1 In order to understand the enhanced stability of misoprostol oil in HPMC, the physical state of misoprostol oil in HPMC films was investigated using differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and transmission IR (TIR). Further, to determine the effect of polymer structure and the mobility of both water and misoprostol on misoprostol stability, the rate of misoprostol degradation was investigated in the misoprostol/HPMC dispersion (1:100) at 55°C. The water sorption isotherm of the dispersion at 55°C was determined, at seven different relative humidities, ranging from zero to 81%. The DSC and DMA measurements indicated that misoprostol oil, up to 29% in dry weight, is molecularly dispersed in the glassy HPMC. The TIR studies showed no evidence of complexation between misoprostol and HPMC. Stability studies of the misoprostol/HPMC (1:100) dispersion indicated that the first-order rate constants for misoprostol degradation increased in a concave-up fashion as the water content of the dispersion increased. Below two percent water content, the rate of misoprostol degradation was found to be minimal. Overall, it is suggested that misoprostol is stabilized in the dispersion by being molecularly dispersed in HPMC. Further, the glassy state of HPMC should reduce the mobility of misoprostol and water, leading to a minimal rate of degradation for misoprostol at low moisture levels.

Keywords

Differential Seanning Calorimetry Solid Dispersion Dynamic Mechanical Analysis Differential Seanning Calorimetry Thermogram Glassy Polymer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Tugrul T. Kararli
    • 1
  • Thomas Catalano
    • 1
  • Thomas E. Needham
    • 1
  • Pat M. Finnegan
    • 1
  1. 1.Product DevelopmentG. D. Searle & Co.SkokieUSA

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