Critical Cellular Events During Cortical Evolution: Radial Unit Hypothesis

  • Pasko Rakic
Part of the NATO ASI Series book series (NSSA, volume 200)


The question of cerebral evolution is among the oldest and most difficult, perhaps because one cannot expect that a single and simple answer can explain complex cellular changes. Furthermore, the genetic, molecular and cell biological mechanisms by which the brain evolves to match an ever changing environment are still largely unexplored. There is, however, little disagreement among contemporary neuroscientists that emergence of distinctly human mental capacities reflect the expansion of the cerebral neocortex (Rakic and Singer, 1988). The present article is concerned with the cellular mechanisms that may underlay the evolution of this remarkable structure and formation of cytoarchitectonic maps in primates.


Visual Cortex Ventricular Zone Cortical Plate Radial Glial Cell Thalamic Input 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Pasko Rakic
    • 1
  1. 1.Yale University School of MedicineNew HavenUSA

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