CU1+Assisted Nucleophilic Exchange Radiohalogenation: Application and Mechanistic Approach

  • J. Mertens
  • M. Gysemans

Abstract

During the last ten years the development of radiopharmaceuticals for SPECT was a continuous struggle between radioiodinated compounds and 99mTc labeled radiopharmaceuticals. If 99mTc labeled compounds won as far as pure “routine radiopharmaceuticals” for blood flow, kidneys and heart were concerned, the development of 123I labeled receptor and metabolic tracers gained more interest. The major part of the radioiodinated pharmaceuticals belong to the iodoarylcompounds.

Keywords

High Performance Liquid Chromatography Isotopic Exchange High Specific Activity Halogen Bond Aryl Halide 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • J. Mertens
    • 1
  • M. Gysemans
    • 1
  1. 1.VUB-CyclotronVrije Universiteit BrusselBelgium

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