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Robotic Thin Layer Chromatography Instrument for Synthetic Chemistry

  • L. Andrew Corkan
  • Evan Haynes
  • Steven Kline
  • Jonathan S. Lindsey

Abstract

We have constructed a second generation instrument for performing automated thin layer chromatography (TLC). The TLC instrument consists of four dedicated stations for 1) plate dispensing, 2) sample application, 3) plate development, and 4) densitometry. A robot is used to move TLC plates among stations. The TLC instrument functions either as a stand-alone unit or as one analytical module in a robotic workstation for synthetic chemistry. An integrated hardware and software architecture enables automatic TLC analysis of samples produced concurrently from synthetic reactions in progress on the workstation. The combination of fixed automation and robotics gives a throughput of 12 TLC samples per hour. From these results a blueprint has emerged for an advanced automated TLC instrument with far greater throughput and analytical capabilities.

Keywords

High Pressure Liquid Chromatography Thin Layer Chromatography Plate Generation Instrument Sample Application Sample Storage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Reference

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • L. Andrew Corkan
    • 1
  • Evan Haynes
    • 1
  • Steven Kline
    • 1
  • Jonathan S. Lindsey
    • 1
  1. 1.Department of ChemistryCarnegie Mellon UniversityPittsburghUSA

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