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Radioisotope Incorporation Via Aryl and Alkenyl Trialkyltin Intermediates

  • Robert N. Hanson

Abstract

Organometallic chemistry has long played an important role in the synthesis of structurally unique and complex bioorganic compounds; however, it has been only within the last decade that the principles developed for synthetic organic chemistry have been applied to radiopharmaceutical chemistry. Since 1978 one can observe, in addition to the organotin reagents, the use of organolithium and Grignard reagents [3–4], organoboranes [5–8], organomercurials [9–11], and organosilanes [12–16] in the preparation of radio-chemicals. Although each of these reagents possesses certain methodological advantages, none can be applied to synthesis of all classes of compounds nor to the incorporation of all radionuclides. Organostannanes, organoboranes and organosilanes share many similar features with respect to the types of radionuclides that can be introduced and the classes of compounds which are accessible to radioisotope incorporation. However, it is the special features associated with the organostannanes that have made them of particular interest to us in our radiopharmaceutical chemistry program.

Keywords

High Specific Activity Aryl Halide Peracetic Acid Grignard Reagent Electrophilic sUbstitution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Robert N. Hanson
    • 1
  1. 1.College of Pharmacy and Allied Health ProfessionsNortheastern UniversityBostonUSA

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