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Radioisotope Incorporation Via Aryl and Alkenyl Trialkyltin Intermediates

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New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control

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Abstract

Organometallic chemistry has long played an important role in the synthesis of structurally unique and complex bioorganic compounds; however, it has been only within the last decade that the principles developed for synthetic organic chemistry have been applied to radiopharmaceutical chemistry. Since 1978 one can observe, in addition to the organotin reagents, the use of organolithium and Grignard reagents [3–4], organoboranes [5–8], organomercurials [9–11], and organosilanes [12–16] in the preparation of radio-chemicals. Although each of these reagents possesses certain methodological advantages, none can be applied to synthesis of all classes of compounds nor to the incorporation of all radionuclides. Organostannanes, organoboranes and organosilanes share many similar features with respect to the types of radionuclides that can be introduced and the classes of compounds which are accessible to radioisotope incorporation. However, it is the special features associated with the organostannanes that have made them of particular interest to us in our radiopharmaceutical chemistry program.

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  1. College of Pharmacy and Allied Health Professions, Northeastern University, 360 Huntington Ave., Boston, MA, 02115, USA

    Robert N. Hanson (Professor of Medicinal Chemistry)

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  1. The University of Texas Health Science Center, Houston, Texas, USA

    Ali M. Emran

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Hanson, R.N. (1991). Radioisotope Incorporation Via Aryl and Alkenyl Trialkyltin Intermediates. In: Emran, A.M. (eds) New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0626-7_28

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  • DOI: https://doi.org/10.1007/978-1-4899-0626-7_28

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