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Synthesis of Radiopharmaceuticals Via Organoboranes

  • George W. Kabalka
  • Mark M. Goodman

Abstract

Radiopharmaceuticals containing complex functional groups are playing an increasing role in diagnostic nuclear medicine due to new developments in the instrumentation used for single-photon emission computerized tomography (SPECT)1 and positron emission tomography (PET).2 These computerized systems permit noninvasive, in vivo, three-dimensional imaging of organs after administration of appropriate agents labeled with short-lived nuclides.3 The techniques are used for in vivo pharmacokinetics, organ imaging, evaluation of organ function, and physiological mapping. They complement the traditional X-ray scan and are’partially responsible for the tremendous upsurge in the use of radiopharmaceuticals in hospitals today.

Keywords

Positron Emission Tomography Boronic Acid Carbonylation Reaction Arylboronic Acid Alkyl Iodide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • George W. Kabalka
    • 1
    • 2
  • Mark M. Goodman
    • 2
  1. 1.Department of ChemistryThe University of TennesseeKnoxvilleUSA
  2. 2.Department of RadiologyThe University of TennesseeKnoxvilleUSA

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