Use of Organolithium and Organomagnesium Reagents in Radiopharmaceutical Synthesis

  • Richard E. Ehrenkaufer
  • James G. Scripko

Abstract

Reactive organometallics of lithium and magnesium are common intermediates in standard organic synthesis. As well, these reagents have been applied early and frequently in the synthesis of radiopharmaceuticals particularly in their labeling with short lived positron emitting isotopes. Reagents consisting of alkyl, cycloalkyl and aryl carbanions, α-amino-carbanions, anions of α-nitroalkanes, isocyanates, isonitriles and thioketals are among the useful. Reaction of these organometallics with eager or reluctant electrophiles such as CO2, CH3I, CO, F2, AcOF, RfOF, FCl03, etc. provide a diverse battery of synthetic approaches for the radiopharmaceutical chemist.

Keywords

Fluorinating Agent Tricarbonyl Chromium Label Comp Phenyl Lithium Tricarbonyl Chromium Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Richard E. Ehrenkaufer
    • 1
  • James G. Scripko
    • 1
  1. 1.PET Center Cyclotron FacilityUniversity of PennsylvaniaPhiladelphiaUSA

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