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Use of Organolithium and Organomagnesium Reagents in Radiopharmaceutical Synthesis

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New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control

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Abstract

Reactive organometallics of lithium and magnesium are common intermediates in standard organic synthesis. As well, these reagents have been applied early and frequently in the synthesis of radiopharmaceuticals particularly in their labeling with short lived positron emitting isotopes. Reagents consisting of alkyl, cycloalkyl and aryl carbanions, α-amino-carbanions, anions of α-nitroalkanes, isocyanates, isonitriles and thioketals are among the useful. Reaction of these organometallics with eager or reluctant electrophiles such as CO2, CH3I, CO, F2, AcOF, RfOF, FCl03, etc. provide a diverse battery of synthetic approaches for the radiopharmaceutical chemist.

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Authors and Affiliations

  1. PET Center Cyclotron Facility, University of Pennsylvania, Philadelphia, PA, 19104-6063, USA

    Richard E. Ehrenkaufer & James G. Scripko

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  1. Richard E. Ehrenkaufer
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  2. James G. Scripko
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Editors and Affiliations

  1. The University of Texas Health Science Center, Houston, Texas, USA

    Ali M. Emran

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© 1991 Springer Science+Business Media New York

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Ehrenkaufer, R.E., Scripko, J.G. (1991). Use of Organolithium and Organomagnesium Reagents in Radiopharmaceutical Synthesis. In: Emran, A.M. (eds) New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0626-7_24

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  • DOI: https://doi.org/10.1007/978-1-4899-0626-7_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0628-1

  • Online ISBN: 978-1-4899-0626-7

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