The Study on the Formulation of a Tc(V)-99m-DMS Lyophilized Instant Kit for Tumor Scintigraphy
The Tc(V)-99m Dimercaptosuccinate (DMS) as a tumor seeking agent has been studied by several laboratories. The published preparation methods were either in situ complexation or two step constitution of commercial renal imaging kit. A new formulation of lyophilized instant kit for one step preparation of Tc(V)-99m DMS complex has been developed in this study. High labeling yield (over 95%) and good shelf stability of the kit were obtained in our laboratory by investigating the formulation of Tc-99m complexes with radio-TLC, electrophoresis and HPLC methods. The results of clinical trial showed the superiority of scintigraphy for diagnosis of bone tumors, soft-tissue tumors and their malignant metastases.
KeywordsHigh Performance Liquid Chromatography Stannous Chloride High Performance Liquid Chromatography Method Dimercaptosuccinic Acid Radioactive Species
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