Radiochemistry of Monoclonal Antibody Labeling

  • Lee C. Washburn


Monoclonal antibodies (MoAbs) to tumor-associated antigens are useful for targeting radionuclides to tumors for both diagnostic and therapeutic applications. MoAbs have been radiolabeled with numerous gamma-, beta-, alpha-, positron-, and Auger electron-emitting radionuclides. Key radionuclide examples for each type of emission are shown in Table 1. Some radionuclides, e.g., iodine-131 (131I), exhibit both beta and gamma emissions and, therefore, may be used for both radioimmunodiagnosis (RID) and radioimmunotherapy (RIT). The chemical properties of the radionuclides listed in Table 1 are very different, and consequently different radiolabeling methods must be used. The purposes of this paper are to review the radiochemistry involved in labeling MoAbs with several of the radionuclides commonly used in nuclear medicine and to examine some special techniques aimed at increasing the tumor-to-nontumor concentration ratios obtained with radiolabeled MoAbs.


Active Ester Sodium Cyanoborohydride Bifunctional Chelate Oligosaccharide Moiety Bifunctional Chelate Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Lee C. Washburn
    • 1
  1. 1.Medical Sciences DivisionOak Ridge Associated UniversitiesOak RidgeUSA

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