The Role of Reducing Agents and the Physiology of Trophozoite Attachment
Giardia lamblia trophozoites are actively motile, yet they attach to the intestinal epithelium via the ventral adhesive or striated disc (Morecki and Parker, 1967; Owen, 1980). Attachment may influence the pathophysiology of the disease. The organisms must adhere strongly enough not to be swept away by peristalsis and movement of the intestinal fluid. They must also be able to detach and reattach so as not to be sloughed off in the constant renewal of epithelial cells. Thus, it is important to understand factors which influence trophozoite attachment. In vivo, such factors are difficult to assess or identify in the complex host-parasite interactions. Therefore, it is important to study simpler in vitro systems.
KeywordsAscorbic Acid Maintenance Medium Thioglycollic Acid Entamoeba Histolytica Giardia Lamblia
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