Some Perspectives on the Transmission of Giardiasis

  • William J. Bemrick

Abstract

A number of aspects of the genus Giardia have been a source of great controversy among parasitologists for decades. Much of the difficulty centers around the taxonomy of this flagellate. This has never been completely resolved; it will be discussed further later in this chapter. Giardia spp. investigations proceeded, at a fairly constant level, until the mid-1960s, when research publications pertaining to this parasite diminished considerably. The work with Giardia was continued, over a period of about a decade, by a small group of dedicated workers, without the benefit of much financial support for their research. One reason for this lack of support has been the belief that this organism is of no public health significance in our society. It was considered, and with considerable justification, to be a rather unusual flagellate of doubtful pathologic significance. Many considered it to be more of an exotic parasite, which on occasion produced a diarrheic syndrome in travelers. The research, of course, did progress, and a considerable amount of significant information was developed in such areas as in vitro cultivation (Meyer, 1976; Fortess and Meyer, 1976) and cellular morphology, using both transmission and scanning electron microscopy (Friend, 1966; Erlandsen, 1974; Erlandsen and Chase, 1974; Sheffield and Bjorvatn, 1977) and immunology, by Roberts-Thomson and his co-workers (1976, 1981), Stevens et al. (1978), Visvesvara and Healy (1980), Visvesvara et al. (1980), and many others.

Keywords

Giardia Lamblia Intestinal Protozoan Fecal Examination Giardia Cyst Giardia Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ansari, M. A. R., 1952, Contribution à l’étude du genre Giardia Kunstler, 1882 (Mastigophora: Octomitidae), Ann. Parasitol. Hum. Comp. 27:421–479.PubMedGoogle Scholar
  2. Armaghan, V., 1937, Biological studies on the Giardia of rats, Am. J. Hyg. 26:236–258.Google Scholar
  3. Associated Press, 1979, Parasite-ridden beavers pinpointed as source of illness in Pennsylvania, Minneapolis Tribune, Nov. 6, 1979, p. 4B.Google Scholar
  4. Aust Kettis, A., and Magnius, L., 1973, Giardia lamblia infection in a group of students after a visit to Leningrad in March, 1970, Scand. J. Infect. Dis. 5:289–292.Google Scholar
  5. Barbour, A. G., Nichols, C. R., and Fukushima, T., 1976, An outbreak of giardiasis, Am. J. Trop. Med. Hyg. 25:384–389.PubMedGoogle Scholar
  6. Bemrick, W. J., 1962, The host specificity of Giardia from laboratory strains of Mus musculus and Rattus norvegicus, J. Parasitol. 68:287–290.CrossRefGoogle Scholar
  7. Bemrick, W. J., 1963, Observations on dogs infected with Giardia, J. Parasitol. 49:1031–1032.PubMedCrossRefGoogle Scholar
  8. Bingham, A. K., and Meyer, E. A., 1979, Giardia excystation can be induced in vitro in acidic solution, Nature (London) 277:301–302.CrossRefGoogle Scholar
  9. Boeck, W. C, 1917, Mitosis in Giardia microti, Univ. Calif. Publ. Zool. 19:85–134.Google Scholar
  10. Brandborg, L. L., Tankersley, L. B., Gottlieb, S., Barancik, S., and Sartor, V. E., 1967, Histological demonstration of mucosal invasion by Giardia lamblia in man, Gastroen-terology 52:143–150.Google Scholar
  11. Brodsky, R. E., Spencer, H. C, Jr., and Schultz, M. G., 1974, Giardiasis in American travelers to the Soviet Union, J. Infect. Dis. 130:319–323.PubMedCrossRefGoogle Scholar
  12. Chakravarti, A., 1968, Giardiasis and its treatment with particular reference to Flagyl therapy, Indian Pract. 21:808–814.Google Scholar
  13. Conroy, D. A., 1960, Giardia in Christmas pudding, Rev. Iber. Parasitol. 20:567–571.Google Scholar
  14. Craun, G. F., 1979, Waterborne giardiasis in the United States: A review, Am. J. Public Health 69:817–819.PubMedCrossRefGoogle Scholar
  15. Cripps, A., Denny, P. J., Fisher, S., Green, P., and O’Connor, B. F., 1975, A health and social survey of a group of children from rural New South Wales, Med. J. Aust. 2:214–218.PubMedGoogle Scholar
  16. Cutting, J. W., 1975, A survey of intestinal parasitism in a community of the Pan American highway route in eastern Panama, Bull. Pan. Am. Health Organ. 9:13–18.PubMedGoogle Scholar
  17. Danciger, M., and Lopez, M., 1975, Number of Giardia in the feces of infected children, Am. J. Trop. Med. Hyg. 24:237–242.PubMedGoogle Scholar
  18. Davies, R., 1978, Giardiasis: A problem in Colorado, Wildl. Dis. Assoc. Newsl. (January), p. 3.Google Scholar
  19. Davies, R. B., and Hibler, C. P., 1979, Animal reservoirs and cross-species transmission of Giardia, in: Waterborne Transmission of Giardiasis (W. Jakubowski and J. C. Hoff, eds.), Environmental Protection Agency 600/9-79-001, pp. 104-126.Google Scholar
  20. DeCarneri, I., Trane, F., and Mandelli, V., 1977, Giardia muris: Oral infection with one trophozoite and generation time in mice, Trans. R. Soc. Trop. Med. Hyg. 71:438.CrossRefGoogle Scholar
  21. Dritz, S. K., 1980, Medical aspects of homosexuality, N. Engl.J. Med. 302:463–464.PubMedCrossRefGoogle Scholar
  22. Dykes, A. C, Juranek, D. D., Lorenz, R. A., Sinclair, S., Jakubowski, W., and Davis, R., 1980, Municipal waterborne giardiasis: An epidemiologic investigation, Ann. Intern. Med. 92:165–170.PubMedCrossRefGoogle Scholar
  23. Erlandsen, S. L., 1974, Scanning electron microscopy of intestinal giardiasis: Lesions of the microvillous border of villus epithelial cells produced by trophozoites of Giardia, in Scanning Electron Microscopy, 1973 (O. Johari, ed.), pp. 775–782, IIT Research Institute, Chicago.Google Scholar
  24. Erlandsen, S. L., and Chase, D. G., 1974, Morphologic alterations in the microvillous border of villous epithelial cells produced by intestinal microorganisms, Am. J. Clin. Nutr. 27:1277–1286.PubMedGoogle Scholar
  25. Fantham, H. B., and Porter, A., 1916, The pathogenicity of Giardia (Lamblia) intestinalis to men and to experimental animals, Biol. Med. J. 2:139–141.Google Scholar
  26. Felman, Y. M., and Nikitas, M. A., 1979, Sexually transmitted enteric pathogens in New York City, N.Y. State J. Med. 79:1412–1413.PubMedGoogle Scholar
  27. Filice, F. P., 1952, Studies on the cytology and life history of a Giardia from the laboratory rat, Univ. Calif. Publ. Zool. 57:53–143.Google Scholar
  28. Fortess, E., and Meyer, E. A., 1976, Isolation and axenic cultivation of Giardia trophozoites from the guinea pig, J. Parasitol. 62:689.PubMedCrossRefGoogle Scholar
  29. Friend, D. S., 1966, The fine structure of Giardia muris, J. Cell Biol. 29:317–332.PubMedCrossRefGoogle Scholar
  30. Frost, F., Plan, B., and Liechty, B., 1980, Giardia prevalence in commercially trapped animals, J. Environ. Health 42:245–249.Google Scholar
  31. Geddes, A. M., 1973, Giardiasis in England, Br. Med. J. 4:236.PubMedCrossRefGoogle Scholar
  32. Grant, D. R., and Woo, P. T. K., 1978a, Comparative studies of Giardia spp. in small animals in southern Ontario. I. Prevalence and identity of the parasites with a taxonomic discussion of the genus, Can. J. Zool. 56:1348–1359.PubMedCrossRefGoogle Scholar
  33. Grant, D. R., and Woo, P. T. K., 1978b, Comparative studies on Giardia spp. in small mammals in southern Ontario. II. Host specificity and infectivity of stored cysts, Can. J. Zool. 56:1360–1366.PubMedCrossRefGoogle Scholar
  34. Grant, D. R., and Woo, P. T. K., 1979, Comparative studies on Giardia spp. in small mammals in southern Ontario. III. Duration and cyst production in natural and experimental infections, Can.J. Zool. 57:307–313.PubMedCrossRefGoogle Scholar
  35. Haiba, M. H., 1956, Further study on the susceptibility of murines to human giardiasis, Z. Parasitenkd. 17:339–345.PubMedCrossRefGoogle Scholar
  36. Harinasuta, C., Sornamani, S., Migasena, P., Vivatanasesth, P., Pongpaew, P., Intarakao, L., and Vudhivai, N., 1976, Socioeconomic, health and nutritional status of the villagers in the Hong Wai irrigation area, Khou Kaen, northeast Thailand, Southeast Asian J. Trop. Med. Public Health 7:601–621.PubMedGoogle Scholar
  37. Hegner, R. W., 1922, A comparative study of the giardias living in man, rabbit, and dog, Am. J. Hyg. 2:442–454.Google Scholar
  38. Hegner, R. W., 1926, The biology of host-parasite relationships among protozoa living in man, Q. Rev. Biol 1:393–418.CrossRefGoogle Scholar
  39. Hewlett, E. L., Andrews, J. S., Jr., Ruffier, J., and Schaefer, F. W., III, 1982, Experimental infection of mongrel dogs with Giardia lamblia cysts and cultured trophozoites, J. Infect. Dis. 145:89–93.PubMedCrossRefGoogle Scholar
  40. Jokipii, L., and Jokipii, A. M. M., 1974, Giardiasis in travelers: A prospective study, J. Infect. Dis. 130:295–299.PubMedCrossRefGoogle Scholar
  41. Karapetyan, A. E., 1960, A method of cultivation of Lamblia, Tsitologiya 2:379–384.Google Scholar
  42. Kean, B. H., William D. C, and Luminais, S. K., 1979, Epidemic of amoebiasis and giardiasis in a biased population, Br. J. Verier. Dis. 55:375–378.Google Scholar
  43. Keifer, A., Roberto, R. R., Powers, L., Gaston, J., Sherwood, R. W., Johnston, L., Blair, J., Early, B., Hopkins, R. S., Scott, E., Smede, R., Osterud, H., Slifman, N., Shilke, J., Hills, L., Goodins, J. A., Burkhart, T. J., Jenkins, M. T., Witte, E. J., McCarthy, M., de Melfî, T., Erb, J., and Lippy, E. C, 1980, Waterborne giardiasis in California, Colorado, Oregon, Pennsylvania, Morbid. Mortal. Weekly Rep. 29:127–123.Google Scholar
  44. Kirner, J. C, Littler, J. D., and Angelo, L. A., 1978, A waterborne outbreak of giardiasis in Camas, Washington, J. Am. Water Works Assoc. 70:35–40.Google Scholar
  45. Klima, M., Gyorkey, M. A., Min, K., and Gyorkey, F., 1977, Electron microscopy in the diagnosis of giardiasis, Arch. Pathol. Lab. Med. 101:133–135.PubMedGoogle Scholar
  46. Knight, R., 1980, Epidemiology and transmission of giardiasis, Trans. R. Soc. Trop. Med. Hyg. 74:433–436.PubMedCrossRefGoogle Scholar
  47. Kulda, J., and Nohynkova, E., 1978, Flagellates of the human intestine and of intestines of other species, in: Protozoa of Veterinary and Medical Interest (J.P. Kreier, ed.), 2:1–138, Academic Press, New York.Google Scholar
  48. Lavier, G., 1924, Deux especes de Giardia du rat d’egout Parisien (Epimys norvegicus), Ann. Parasitol. Hum. Comp. 11:161–168.Google Scholar
  49. Lippy, E. C, 1978, Tracing a giardiasis outbreak at Berlin, New Hampshire, J. Am. Water Works Assoc. 70:512–520.Google Scholar
  50. Mastrandrea, G., and Micarelli, A., 1968, Search for parasites in vegetables from the local markets in the city of Rome, Arch. Ital. Sci. Med. Trop. Parassitol. 49:55–59.PubMedGoogle Scholar
  51. Meyer, E. A., 1976, Giardia lamblia: Isolation and axenic cultivation, Exp. Parasitol. 39:101–105.PubMedCrossRefGoogle Scholar
  52. Meyer, E. A., and Jarroll, E. L., 1980, Giardiasis, Am. J. Epidemiol 111:1–12.PubMedGoogle Scholar
  53. Meyers, J. D., Kuharic, H. A., and Holmes, K. K., 1977, Giardia lamblia infection in homosexual men, Br. J. Vener. Dis. 53:54–55.PubMedGoogle Scholar
  54. Morecki, R., and Parker, J. G., 1967, Ultrastructural studies of the human Giardia lamblia and subjacent jejunal mucosa in a subject with steatorrhea, Gastroenterology 52:151–164.PubMedGoogle Scholar
  55. Most, H., 1968, Manhattan: A “tropic isle”?, Am. J. Trop. Med. Hyg. 17:333–354.PubMedGoogle Scholar
  56. Naiman, H. L., Sekla, L., and Albritton, W. L., 1980, Giardiasis and other intestinal parasitic infections in a Manitoba residential school for the mentally retarded Can. Med. Assoc. J. 122:185–188.PubMedGoogle Scholar
  57. Nalin, D. R., Rhead, J., Rennels, M., O’Donnell, S., Levine, M. M., Bergquist, E., Hughes, T., and Hormick, R. B., 1978, Cannabis, hypochlorhydria and cholera, Lancet 2:859–862.PubMedCrossRefGoogle Scholar
  58. Nemanic, P., Owen, R. L., Stevens, D. P., and Mueller, J. S., 1979, Ultrastructural observations on giardiasis in a murine model. II. Endosymbiosis and organelle distribution in Giardia muris and comparison with Giardia lamblia, J. Infect. Dis. 110:222–228.CrossRefGoogle Scholar
  59. Nieschulz, O., 1924, Über den Bau von Giardia caprae Mihi, Arch. Protistenkd. 49:278–286.Google Scholar
  60. Osterholm, M. T., Forfang, J. C, Ristenen, T. L., Dean, A. G., Washburn, J. W., Godes, J. R., Rude, R. A., and McCullough, J. G., 1981, An outbreak of foodborne giardiasis, N. Engl. J. Med. 304:24–28.PubMedCrossRefGoogle Scholar
  61. Padchenko, J. K., and Stolyarchuk, N. G., 1970, Dogs as a spontaneous carrier of Lamblia and probable source and vector lambliosis in nature, Vestn. Zool. 4:56–61.Google Scholar
  62. Rendtorff, R. C, 1954, The experimental transmission of human intestinal parasites. II: Giardia lamblia cysts given in capsules, Am. J. Hyg. 59:209–220.PubMedGoogle Scholar
  63. Rendtorff, R. C, 1975, Giardia in water, Ann. Intern. Med. 82:280–281.PubMedCrossRefGoogle Scholar
  64. Ridley, M. J., and Ridley, D. S., 1976, Serum antibodies and jejunal histology in giardiasis associated with malabsorption, J. Clin. Pathol. 29:30–34.PubMedCrossRefGoogle Scholar
  65. Roberts-Thomson, I. C, and Anders, R. F., 1981, Serum antibodies in adults with giardiasis, Gastroenterology 80:1262.Google Scholar
  66. Roberts-Thomson, I. C, Stevens, D. P., Mahmoud, A. A. F., and Warren, K. S., 1976, Giardiasis in the mouse: An animal model, Gastroenterology 71:57–61.PubMedGoogle Scholar
  67. Saha, T. K., and Ghosh, T. K., 1977, Invasion of the small intestinal mucosa by Giardia lamblia in man, Gastroenterology 72:402–405.PubMedGoogle Scholar
  68. Sebesteny, A., 1974, The transmission of intestinal flagellates in mice, Lab. Anim. 3:71–77.CrossRefGoogle Scholar
  69. Sehgal, A. K., Grewal, M. S., Chakravarti, R. N., Broor, S. L., Deka, N. C, and Chhuttani, P. N., 1976, Experimental giardiasis in albino rats, Indian J. Med. Res. 64:1015–1018.PubMedGoogle Scholar
  70. Shaw, P. K., Brodsky, R. E., Lyman, D. O., Wood, B. T., Hibler, C. P., Healy, G. R., MacLeod, K. I. E., Stahy, W., and Schultz, M. G., 1977, A community-wide outbreak of giardiasis with evidence of transmission by a municipal water supply, Ann. Intern. Med. 87:426–432.PubMedCrossRefGoogle Scholar
  71. Sheffield, H. G., and Bjorvatn, B., 1977, Ultrastructure of the cyst of Giardia lamblia, Am. J. Trop. Med. Hyg. 26:23–30.PubMedGoogle Scholar
  72. Shelton, G. C., 1954, Giardiasis in the chinchilla. I. Observations on morphology, location in the intestinal tract and host specificity, Am. J. Vet. Res. 15:71–74.PubMedGoogle Scholar
  73. Simon, C. E., 1922, A critique of the supposed rodent origin of human giardiasis, Am. J. Hyg. 1:406–434.Google Scholar
  74. Smith, P. D., Gillin, F. D., Brown, W. R., and Nash, T. E., 1981, IgG antibody to Giardia lamblia detected by enzyme-linked immunosorbent assay, Gastroenterology 80:1476–1480.PubMedGoogle Scholar
  75. Stevens, D. P., Frank, D. M., and Mahmoud, A. A. F., 1978, Thymus dependency of host resistance to Giardia muris infection: Studies in nude mice, J. Immunol. 120:680–682.PubMedGoogle Scholar
  76. Veazie, L., 1969, Epidemic giardiasis, N. Engl. J. Med. 281:853.PubMedGoogle Scholar
  77. Visvesvara, G. S., and Healy, G. R., 1980, The possible use of an indirect immunoflu-orescent test using axenically grown Giardia lamblia antigens in diagnosing giardiasis, in: Waterborne Transmission of Giardiasis (W. Jakubowski and J. C. Hoff, eds.), Environmental Protection Agency, 600/9-79-001, pp. 53-63.Google Scholar
  78. Visvesvara, G. S., Smith, P. D., Healy, G. R., and Brown, W. R., 1980, An immunofluo-rescence test to detect serum antibodies to Giardia lamblia, Ann. Intern. Med. 93:802–805.PubMedCrossRefGoogle Scholar
  79. Walzer, P. D., Wolfe, M. S., and Schultz, M. G., 1971, Giardiasis in travelers, J. Infect. Dis. 124:235–237.PubMedCrossRefGoogle Scholar
  80. Wenrich, D. H., 1940, Observations on parasites and inclusion bodies in certain intestinal protozoa, Science 92:416–417.Google Scholar
  81. Zisman, M., 1977, Blood group A and giardiasis, Lancet 2:1285.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • William J. Bemrick
    • 1
  1. 1.Department of Pathobiology, College of Veterinary MedicineUniversity of MinnesotaSt. PaulUSA

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