Abstract
Researchers have sought, for a variety of reasons, to develop a system in which a given strain of Giardia could infect laboratory animals, cause disease that mimics giardiasis in humans, and is excreted as cysts that in turn will reliably infect other animals. The reasons for developing such an animal model have been as diverse as studying the mechanism of Giardia pathogenesis, analyzing the characteristics of Giardia infections, determining the stability and infectivity of trophozoites and cysts, studying the host immune response, and ensuring a continuing supply of cysts from a known strain of the organism.
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References
Anand, B. S., Kumar, M., Chakravarti, R. N., Sehgal, A. K., and Chhuttani, P. N., 1980. Pathogenesis of malabsorption in Giardia infection: An experimental study in rats, Trans. R. Soc. Trop. Med. Hyg. 74:565–570.
Anand, B. S., Mahmood, A., Ganguly, N. K., Rehani, M. M., Dilawari, J. B., and Mahajan, R. C, 1982, Transport studies and enzyme assays in mice infected with human Giardia lamblia, Trans. R. Soc. Trop. Med. Hyg. 76:616–619.
Anders, R. F., Roberts-Thomson, I. C, and Mitchell, G. F., 1982, Giardiasis in mice: Analysis of humoral and cellular immune responses to Giardia muris, Parasite Immunol. 4:47–57.
Andrews, J. S., and Hewlett, E. L., 1981, Protection against infection with Giardia muris by milk containing antibody to Giardia, J. Infect. Dis. 143:242–246.
Andrews, J. S., Ellner, J. J., and Stevens, D. P., 1979, Identification of anti-Giardia antibodies in murine breast milk, Clin. Res. 27:340A.
Belosevic, M., Faubert, G. M., MacLean, J. D., Law, C., and Croll, N. A., 1983, Giardia lamblia infections in Mongolian gerbils: An animal model, J. Infect. Dis. 147:222–226.
Boorman, G. A., Lina, P. H. C., Zurcher, C., and Nieuwerkerk, 1973, Hexamita and Giardia as a cause of mortality in congenitally thymus-less (nude) mice, Clin. Exp. Immunol. 15:623–627.
Craft, J. C., 1982, Experimental infection with Giardia lamblia in rats J. Infect. Dis. 145:495–498.
Ferguson, A., Gillon, J., and Al Thamery, D., 1980, Intestinal abnormalities in murine giardiasis, Trans. R. Soc. Trop. Med. Hyg. 74:445–448.
Gillon, J., Al Thamery, D., and Ferguson, A. 1982, Features of small intestinal pathology (epithelial cell kinetics, intraepithelial lymphocytes, disaccharidases) in a primary Giardia muris infection, Gut 23:498–506.
Hewlett, E. L., Andrews, J. S., Ruffier, J., and Schaefer, F. W., 1982, Experimental infection of mongrel dogs with Giardia lamblia cysts and cultured trophozoites, J. Infect. Dis. 145:89–93.
Hill, D. R., Guerrant, R. L., Pearson, R. D., and Hewlett, E. L., 1983, Giardia lamblia infection of suckling mice, J. Infect. Dis. 147:217–221.
Nemanic, P. C., Owen, R. L., Stevens, D. P., and Mueller, J. C, 1979, Ultrastructural observations on giardiasis in a mouse model. II. Endosymbiosis and organelle distribution in Giardia muris and Giardia lamblia, J. Infect. Dis. 140:222–228.
Olveda, R. K., Andrews, J. S., and Hewlett, E. L., 1982, Murine giardiasis: Localization of trophozoites and small bowel histopathology during the course of infection, Am. J. Trop. Med. Hyg. 31:60–66.
Owen, R. L., Nemanic, P. C., and Stevens, D. P., 1979, Ultrastructural observations on giardiasis in a murine model. I. Intestinal distribution, attachment, and relationship to the immune system of Giardia muris, Gastroenterology 76:757–769.
Owen, R. L., Allen, C. L., and Stevens, D. P., 1981, Phagocytosis of Giardia muris by macrophages in Peyer’s patch epithelium in mice, Infect. Immun. 33:591–601.
Padchenko, I. K., and Stolyarchuk, N. C, 1969, On the possible circulation of Lamblia in nature, Prog. Protozool. 3:311–312.
Roberts-Thomson, I. C., and Mitchell, G. G., 1978, Giardiasis in mice. I. Prolonged infections in certain mouse strains and hypothymic (nude) mice, Gastroenterology 75:42–46.
Roberts-Thomson, I. C., and Mitchell, G. F., 1979, Protection of mice against Giardia muris infection, Infect. Immun. 24:971–973.
Roberts-Thomson, I. C, Stevens, D. P., Mahmoud, A. A. F., and Warren, K. S., 1976a, Giardiasis in the mouse: An animal model, Gastroenterology 71:57–61.
Roberts-Thomson, I. C., Stevens, D. P., Mahmoud, A. A. F., and Warren, K. S., 1976b, Acquired resistance to infection in an animal model of giardiasis, J. Immunol. 117:2036–2037.
Roberts-Thomson, I. C., Grove, D. I., Stevens, D. P., and Warren, K. S., 1976c, Suppression of giardiasis during the intestinal phase of trichinosis in the mouse, Gut 17:953–958.
Roberts-Thomson, L. C., Mitchell, G. F., Anders, R. F., Tait, B. D., Kerlin, P., Kerr-Grant, A., and Cavanagh, P., 1980a, Genetic studies in human and murine giardiasis, Gut 21:397–401.
Roberts-Thomson, I. C., Anders, R. F., and Mitchell, F. G., 1980b, Giardiasis in mice: Analysis of the humoral and cellular immune response to Giardia muris, Aust. N. Z. J. Med. 10:368.
Roberts-Thomson, I. C., Anders, R. F., Underdown, B. J., and Mitchell, G. G., 1981, Giardia muris in inbred mouse strains, Gastroenterology 80:1283.
Schleinitz, P., Justus, P., Stenzel, P., Owen, R., and Meyer, E., 1983, Successful introduction of culture adapted Giardia into a rabbit model: Ultrastructural features, Gastroenterology 84:1301.
Sehgal, A. K., Grewal, M. S., Chakravarti, R. N., Broor, S. L., Deka, N. C., and Chhuttani, P. N., 1976, Experimental giardiasis in albino rats, Indian J. Med. Res. 64:1015–1018.
Stevens, D. P., 1978, Giardiasis in the mouse: Clues to host immune mechanisms, in: Waterborne Transmission of Giardiasis (W. Jakubowski and J. C. Hoff, eds.), Environmental Protection Agency 600/9-79-001, pp. 82-90.
Stevens, D. P., and Frank, D. M., 1978, Local immunity in murine giardiasis: Is milk protective at the expense of maternal gut?, Trans. Assoc. Am. Physicians 91:268–272.
Stevens, D. P., and Roberts-Thomson, I. C, 1978, Animal model: Experimentally induced giardiasis, Am. J. Pathol. 90:529–532.
Stevens, D. P., Frank, D. M., and Mahmoud, A. A. F., 1978, Thymus dependency of host resistance to Giardia muris infection: Studies in nude mice, J. Immunol. 120:680–682.
Underdown, B. J., Roberts-Thomson, I. C, Anders, R. F., and Mitchell, G. G., 1981, Giardiasis in mice: Studies on the characteristics of chronic infection in C3H/He mice, J. Immunol 126:669–672.
Vinayak, V. K., Sharma, G. L., and Naik, S. R., 1979, Experimental Giardia lamblia infection in Swiss mice—A preliminary report, Indian J. Med. Res. 70:195–198.
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Meyer, E.A., Erlandsen, S.L., Radulescu, S. (1984). Animal Models for Giardiasis. In: Erlandsen, S.L., Meyer, E.A. (eds) Giardia and Giardiasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0594-9_14
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DOI: https://doi.org/10.1007/978-1-4899-0594-9_14
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