Human Immune Responses to Giardia lamblia

  • Phillip D. Smith


Epidemiologic, clinical, and experimental observations indicate that man develops an immune response to Giardia lamblia. Studies of several giardiasis outbreaks (Moore et al., 1969; Barbour et al., 1976) show that individuals repeatedly exposed to G. lamblia have a lower incidence of infection and symptoms than newly exposed individuals, suggesting that prior exposure imparts partial resistance to reinfection. Clinical observations (Hughes et al., 1971; Ajdukiewicz et al., 1972; Ament et al., 1973; Brown et al., 1973; Hermans et al., 1976) of hypogammaglobulinemic patients reveal that these individuals have an increased prevalence of giardiasis, emphasizing the potential importance of antibody in the immunity to this parasite. In addition, a high prevalence of G. lamblia infection in homosexual men (Meyers et al., 1977; Hurwitz and Owen, 1978; Schmerin et al., 1978) suggests that cellular immunity may participate in man’s response to Giardia, since many homosexuals have an acquired T-cell defect (Masur et al., 1982; Siegal et al., 1982; Gottlieb et al., 1982). As discussed in Chapter 11, recent investigations (Roberts-Thomson et al., 1976; Stevens et al., 1978; Roberts-Thomson and Mitchell, 1978) in experimental G. muris infection in mice confirm the role of immunity in the murine response to Giardia, Recently, macrophages have also been implicated in immunity to this parasite, since macrophages of both mice (Owen et al., 1981) and rabbits (Radulescu and Meyer, 1981) are capable of phagocytosing Giardia.


Human Immune Response Giardia Lamblia ADCC Assay Peripheral Blood Granulocyte Minor Antigen 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Phillip D. Smith
    • 1
  1. 1.Laboratory of Microbial ImmunityNational Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesdaUSA

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