Pethidine and Related 4-Phenylpiperidine Analgesics

  • Alan F. Casy
  • Robert T. Parfitt

Abstract

During the late 1930s some 4-phenylpiperidine derivatives were examined as potential spasmolytics on the basis of their chemical relationships to atropine. The antinociceptive properties of one member, ethyl 1-methyl-4-phenylpiperidine-4-carboxylate (1a), were detected during screening tests and the compound was subsequently introduced clinically by Eisleb and Schaumann in 1939.(1) The ester 1a, well known as pethidine in Europe and meperidine in North America (proprietary names include Demerol, Dolantin, and Dolosal), was soon in widespread use for the relief of pain and it is remarkable how pethidine, the original nonopioid-derived analgesic, has retained its popularity in the face of competition from other synthetic analgesics marketed over the past 40 years.

Keywords

Opioid Receptor Aryl Group Potency Ratio Piperidine Ring Analgesic Potency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Alan F. Casy
    • 1
  • Robert T. Parfitt
    • 1
    • 2
  1. 1.University of BathBathUK
  2. 2.Canberra College of Advanced EducationBelconnenAustralia

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