Enkephalins, Endorphins, and Other Opioid Peptides

  • Alan F. Casy
  • Robert T. Parfitt

Abstract

The isolation of naturally occurring peptides with morphinelike properties and the subsequent investigation of synthetic analogs are direct consequences of two major developments in the methodology of study of opioid receptors and their ligands made since 1970. These are (1) the introduction of in vitro testing procedures, notably inhibition of the contraction of electrically stimulated guinea pig ileum (GPI) and mouse vas deferens (MVD), and (2) the detection of opioid receptors in brain and other tissue by binding studies with radiolabeled opioids and the measurement of specific drug-receptor binding constants.

Keywords

Opioid Receptor Opioid Peptide Endogenous Opioid Peptide Analgesic Potency Bivalent Ligand 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Alan F. Casy
    • 1
  • Robert T. Parfitt
    • 1
    • 2
  1. 1.University of BathBathUK
  2. 2.Canberra College of Advanced EducationBelconnenAustralia

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