The Reoviridae pp 229-285 | Cite as

Pathogenesis of Reovirus Infection

  • Arlene H. Sharpe
  • Bernard N. Fields
Part of the The Viruses book series (VIRS)


To successfully produce disease, a virus must enter its host, replicate within host cells, spread within the host and, in the case of systemic infection, overcome host immune defenses, and damage host tissues. At each stage of the infectious process, a number of viral and host factors determine the ultimate pathogenicity (capacity to produce disease) of the virus. Recent studies using the mammalian reoviruses as a model system have provided insights into the roles of viral and host components in the production of disease. The mammalian reoviruses offer an excellent system for the study of molecular aspects of viral pathogenesis because reovirus genetics has provided a means to identify specific viral components involved in the disease process.


Persistent Infection Ependymal Cell Vimentin Filament dsRNA Segment Reovirus Infection 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Arlene H. Sharpe
    • 1
  • Bernard N. Fields
    • 1
    • 2
  1. 1.Department of Microbiology and Molecular GeneticsHarvard Medical SchoolBostonUSA
  2. 2.Department of MedicineBrigham and Women’s HospitalBostonUSA

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