The Reoviridae pp 107-196 | Cite as

The Reovirus Multiplication Cycle

  • Helmut Zarbl
  • Stewart Millward
Part of the The Viruses book series (VIRS)


Human reoviruses have been recovered from a variety of mammals (Stanley, 1961a; Rosen, 1968). Serological studies, which reveal the presence of reovirus specific antibodies, have indicated a ubiquitous distribution of reovirus among mammals (Stanley, 1961a, b; Rosen, 1962). The American Type Culture Collection has suggested at least 14 mammalian cell lines as suitable for the growth of reoviruses, including cell lines derived from 12 different species and 7 different tissue types (see Catalogue of Strains II, 3rd ed., 1981). As a result of this extensive host range, several aspects of the reovirus multiplication cycle have been studied at one time or another in a variety of mammalian cells. However, most of the studies concerning the molecular biology of the reovirus multiplication cycle have been carried out on mouse L fibroblasts infected with the Dearing strain of reovirus type 3. The reason for this is that mouse L cells grow readily in suspension culture and that the Dearing strain multiplies particularly well in these cells. Therefore, the discussion of the events in the reovirus multiplication cycle will of necessity be based primarily on studies of reovirus multiplication in mouse L cells. Wherever appropriate, the discussion will include the multiplication of all three serotypes of human reovirus in a variety of cell lines.


Minus Strand dsRNA Segment Reovirus Infection Parental Transcript Subviral Particle 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Helmut Zarbl
    • 1
  • Stewart Millward
    • 1
  1. 1.Department of BiochemistryMcGill UniversityMontrealCanada

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