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Studies of the Endogenous Opioid System in the Human Stress Response

  • Martin R. Cohen
  • David Pickar
  • Michel Dubois
  • Robert M. Cohen

Abstract

During the last few years, our group has been actively engaged in clinical studies to understand the role of the endogenous opioid system (EOS) in human behavior. In this chapter, we review those of our studies that are most pertinent to our understanding of human behavior during stress and the implications of results from these studies on future strategies to understand and modify, for therapeutic purposes, the role of the EOS in the human stress response.

Keywords

Brief Psychiatric Rate Scale Surgical Intensive Care Unit Plasma Cortisol Level Morphine Sulfate Endogenous Opioid System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Amir, S., Brown, Z.W., and Amit, A., The role of endorphins in stress: Evidence and speculations, Neurosci. Biobehay. Rev. 4: 77 (1980).CrossRefGoogle Scholar
  2. Frederickson, R., and Geary, L., Endogenous opioid peptides: Review of physiological, pharmacological and clinical aspects, Prog. Neurobiol., 19:19–69 (1982).Google Scholar
  3. 3.
    Rossier, J., French, E.D., Rivier, C., Ling, N., Guillemin, R., Bloom, F.E., Foot-shock induced stress increases B-endorphin levels in blood but not brain, Nature 270: 618–620 (1977).PubMedGoogle Scholar
  4. 4.
    Guillemin, R., Vargo, T., Rossier, J., Minicck, S., Ling, N., Rivier, C., Vale, W., Bloom, F., Beta-endorphin and adrenocortiocotropin are secreted concomitantly by the pituitary gland, Science 197: 1367–1369 (1977)Google Scholar
  5. 5.
    Cohen, M., Pickar, D., Dubois, M., Roth, Y., Naber, D., Bunney, W., Jr., Surgical stress and endorphins, Lancet 1213–214 (1981).Google Scholar
  6. 6.
    Dubois, M., Pickar, D., Cohen, M.R., Roth, Y., MacNamara, T., Bunney, W.E. Jr., Surgical stress in humans in accompanied by an increase in plasma B-endorphin immunoreactivity, Life Sciences 29: 1249–1253 (1981).Google Scholar
  7. 7.
    Cohen, M.R., Nurnberger, J., Pickar, D., Gershon, E., Bunney, W., Jr., Dextroamphetamine infusions in normals results in correlated increases of plasma B-endorphin and cortisol immunoreactivity, Life Sciences 29: 1243–1247 (1981).PubMedCrossRefGoogle Scholar
  8. 8.
    Antelman, S., Caggiula, A., Stress-induced behavior: Chemotherapy without drugs in “Psychobiology of Consciousness,” Davidson, J. and Davidson, R.M. eds. Plenum Press, New York 65–104 (1980).Google Scholar
  9. Cohen, R.M., Campbell, I., Cohen, M.R., Torda, T., Pickar, D., Siever, L., Murphy, D., Pre-synapic noradrenergic regulation during depression and antidepressant drug treatment, Psychiatr. Res. 3:93–105 (1980).Google Scholar
  10. 10.
    Shatney, C.H, Cohen, R.M., Cohen, M.R., Imagawa, D.R. Endogenous opioid activity in clinical hemorrhagic shock. Surgery, Gynecology and Obstetrics (in press).Google Scholar
  11. Carr, D., Bullen, B., Skrinar, G., Arnold, M., Rosenblatt, M., Beitins, I., Martin, J.B., McArthur, J., Physical conditioning facilitates the exercise induced secretion of beta-endorphin and beta-lipotropin in women, N. Engl. J. Med., 305:560–563 (1981).Google Scholar
  12. 12.
    Colt, W., Wardlow, S., Frantz, A., The effect of running on plasma beta-endorphin, Life Sciences, 28: 1637–1640 (1981).Google Scholar
  13. Goland, R., Wardlaw, S., Stark, R., Frantz, A., Human plasma beta-endorphin during pregnancy, labor and delivery, J. Clin. Endocrinol. Metab., 52:74–78 (1981).Google Scholar
  14. 14.
    Jaffe, J.H., and Martin, W.R., Narcotic analgesics and antagonists. In The Pharmacological Basis of Therapeutics Edition 6 Goodman, A.G., Goodman, A.S ., and Gilman, L. ( eds ), Macmillian New York (1980).Google Scholar
  15. Stanski, D., Greenblatt, D., and Lowenstein, E., Kinetics of intravenous and intramuscular morphine. Clin. Pharmacol. Ther., 24:52–59 (1978).Google Scholar
  16. Cohen, M.R., Pickar, D., Dubois, M., Bunney, W.E., Jr., Stress induced plasma beta-endorphin immunoreactivity may predict postoperative morphine usage. Psychiatr. Res. 6:7–12 (1982).Google Scholar
  17. 17.
    Foley, K.M., Kourides, I.A., and Inturrisi, C.E., Kaiko, R., Zaroulis, C., Posner, J., Boucle, R., Li, C.H., Beta-endorphin: Analgesic and hormonal effects in humans, Proc. Natl. Acad. Sci., 76: 5377–5381 (1979).Google Scholar
  18. 18.
    Tamsen, A., Hartvig, P., Dahlstrom, B., Wahlstrom, A., Jerenics,L., Endorphins and on demand pain relief, Lancet 1: 769 (1980).Google Scholar
  19. 19.
    Levine, J., Gordon, N., and Field, H., Naloxone dose dependently produces analgesia and hyperalgesia in post-operative pain, Nature 278: 740–741 (1979).Google Scholar
  20. Haier, R., Quaid, K., Mills, J., Naloxone alters pain perception after jogging, Psychiatr. Res., 5:231–232 (1981).Google Scholar
  21. Spiler, I.J., and Molitch, M.E., Lack of modulation of pituitary hormone stress response by neural pathways involving opiate receptors, J. Clin. Endocrinol. Metab., 50:516–520 (1980).Google Scholar
  22. Enquist, A., Hicquet, J. Saubrey, N., Blichert-Toft, M., Cortisol, glucose and hemodynamic responses to surgery after naloxone administration, Acta Anaesthesiol. Scand., 25:17–20 (1981).Google Scholar
  23. 23.
    Cohen, M.R., Cohen, R.M., Pickar, D., Murphy; D., Bunney, W.E., Jr., Physiological effects of high dose naloxone administration to normal adults, Life Sciences 30: 2025–2031 (1982).Google Scholar
  24. Cohen, M.R., Cohen, R.M., Pickar, D., Weingartner, H., Murphy, D.L., High dose naloxone infusions in normals: dose-dependent behavioral, hormonal, and physiological responses, Arch. Gen. Psychiatry, 40:613–619 (1983).Google Scholar
  25. Cohen, M.R., Cohen, R.M., Pickar, D., Sunderland, T., Mueller, E. III., Murphy, D.L., High Dose Naloxone in Depression, Biol. Psychiat., 19:6, 825–832 (1984).Google Scholar
  26. 26.
    Dubois, M., Pickar, D., Cohen, M.R., Gadde, P., Macnamara, T.E., Bunney, W.E., Jr., Effects of fentanyl on the response of plasma beta-endorphin immunoreactivity to surgery, Anesthesiology, 57: 468–472 (1982).Google Scholar
  27. 27.
    Pickar, D., Dubois, M., and Cohen, M., Behavioral change in a cancer patient following intrathecal B-Endorphin Administration, American Journal of Psychiatry, 141: 1, 103–104 (1984).Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Martin R. Cohen
    • 1
    • 2
  • David Pickar
    • 3
  • Michel Dubois
    • 4
  • Robert M. Cohen
    • 5
  1. 1.Ensor Foundation Research LaboratoryWilliam S. Hall Psychiatric InstituteUSA
  2. 2.Department of Neuropsychiatry and Behavioral SciencesUniversity of South CarolinaUSA
  3. 3.Section on Clinical Studies, Clinical Neuroscience BranchNIMHBethesdaUSA
  4. 4.Department of AnesthesiologyGeorgetown University School of MedicineUSA
  5. 5.Section on Brain Imaging, Laboratory of Psychology and PsychopathologyNIMHBethesdaUSA

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