Studies of the Endogenous Opioid System in the Human Stress Response

  • Martin R. Cohen
  • David Pickar
  • Michel Dubois
  • Robert M. Cohen


During the last few years, our group has been actively engaged in clinical studies to understand the role of the endogenous opioid system (EOS) in human behavior. In this chapter, we review those of our studies that are most pertinent to our understanding of human behavior during stress and the implications of results from these studies on future strategies to understand and modify, for therapeutic purposes, the role of the EOS in the human stress response.


Brief Psychiatric Rate Scale Surgical Intensive Care Unit Plasma Cortisol Level Morphine Sulfate Endogenous Opioid System 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Martin R. Cohen
    • 1
    • 2
  • David Pickar
    • 3
  • Michel Dubois
    • 4
  • Robert M. Cohen
    • 5
  1. 1.Ensor Foundation Research LaboratoryWilliam S. Hall Psychiatric InstituteUSA
  2. 2.Department of Neuropsychiatry and Behavioral SciencesUniversity of South CarolinaUSA
  3. 3.Section on Clinical Studies, Clinical Neuroscience BranchNIMHBethesdaUSA
  4. 4.Department of AnesthesiologyGeorgetown University School of MedicineUSA
  5. 5.Section on Brain Imaging, Laboratory of Psychology and PsychopathologyNIMHBethesdaUSA

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