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Methionine Enkephalin: T-Cell Enhancement in Normal Volunteers (in Vivo)

  • N. P. Plotnikoff
  • G. C. Miller
  • S. Solomon
  • R. E. Faith
  • L. Edwards
  • A. J. Murgo

Abstract

Earlier studies by our group indicated that methionine enkephalin enhanced PHA induced lymphocyte proliferation in mice, active rosette forming cells and NK cells in the cells of normal volunteer and cancer patients,(Plotnikoff et. al., 1985). More recently, several groups have reported that methionine enkephalin stimulates macrophage function as well as chemotaxis(Foris, 1984; Weber, 1984). Finally several groups have reported increased lymphokine production by methionine enkephalin(Brown, et al., 1985; Youkilis et al.,1985).

Keywords

Natural Killer Natural Killer Cell Sodium Azide Normal Volunteer Beta Endorphin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Brown, S. L. and Van Epps, E. E., 1985, Beta endorphin (BE), met-enkephalin (ME), and corticotrophin (ACTH) modulate the production of gamma interferon ( INF) in vitro, Fed. Proc., 44: 949.Google Scholar
  2. Einhorn, S., Blomgren, H., Stander, H., and Troye, M., 1983, Activity following treatment with Interferon In Vivo, in: “Mediation of Cellular Immunity in Cancer by Immune Modifiers”, M. A. Chirigos, ed., Raven Press, New York.Google Scholar
  3. DeMaeyer, G., Galasso, G., and Schellenkens, H., eds. 1983, in: “The biology of the interferon system”, 347–352, Elsevier/North Holland Biomedical Press, Amsterdam.Google Scholar
  4. Foris, G., Medgyesi, G. A., Gyimesi, E., and Hauck, M., 1984, Met-enkephalin: induced alterations of macrophage functions, Mol. Immun., 21: 747.CrossRefGoogle Scholar
  5. Plotnikoff, N. P., Murgo, A. J., Miller, G. C., Corder, C. N., and Faith, R. E., 1985, Enkephalins: Immunomodulators, Fed. Proc. 44: 118.PubMedGoogle Scholar
  6. Plotnikoff, N. P., Miller, G. C., Wybran, J., and Nimeh, N. F., April 10, 1985, Methionine enkephalin T-cell enhancement in Kaposis’ sarcoma, Serono Symposium, Copley Plaza Hotel, Boston, Recent Advances in Primary and Acquired Immunodeficiencies (in Press).Google Scholar
  7. Weber, R. J., and Pert, C. B., 1984, Opiatergic modulation of the immune system, in: “Central and Peripheral Endorphins: Basic and Clinical Aspects”, E. E. Muller and A. R. Genezzani, eds., Raven Press, New York.Google Scholar
  8. Youkilis, E., Chapman, J., Woods, E., and Plotnikoff, N., 1985, In Vivo immunostimulation and increased in vitro production of interleukin 1 (IL-1) activity by met-enkephalin, Int. J. Immunopharm., 7: 79.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • N. P. Plotnikoff
    • 1
  • G. C. Miller
    • 2
  • S. Solomon
    • 1
  • R. E. Faith
    • 1
  • L. Edwards
    • 1
  • A. J. Murgo
    • 1
  1. 1.Departments of PharmocologyMedicine Oral Roberts University, School of MedicineTulsaOklahomaUSA
  2. 2.Immuno-Diagnostics LaboratoryTulsaOklahomaUSA

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