Methionine Enkephalin: Clinical Pharmacology

  • N. P. Plotnikoff
  • S. Solomon
  • J. L. Valentine
  • M. Fesen
  • R. E. Faith
  • L. Edwards
  • R. Richter
  • A. J. Murgo
  • G. C. Miller

Abstract

Earlier studies indicated that methionine enkephalin infusions (1,000 micrograms) in normal volunteers induced facial flushing, general vasodilation and noisy stomach (borborgymi). Blood pressure and pulse rate were normal in all experiments. Plasma levels of pancreatic polypeptide, somatostatin, T3 and T4, TSH, FSH, PRL, ACTH, and GH were unchanged. However, there was some reduction of LH (Rolandi et al., 1980, Goldstein et al., 1981). The present study is an evaluation of the effects of methionine enkephalin (over a broad dose range) on all of the vital signs as well as measurements of blood level.

Keywords

Pancreatic Polypeptide Facial Flushing Daily Body Weight Standing Heart Rate Comprehensive Physical Examination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Calimlin, J. F., Sriwatanakul, K., Mardell, W. M., Lasagna, L., and Cox C., 1982, Analgesic efficacy of parenteral met-enkephamide acetate in treatment of post-operative pain (LY 127623), The Lancet, 10 ): 1374.CrossRefGoogle Scholar
  2. del Pozo, E., Kleinstein, J., Brun del Re R., Derrer F., and Martin-Perez, J., 1980, Failure of oxytocin and lysine-vasopressin to stimulate prolactin release in humans, Horm. Metab. Res., 12: 26.Google Scholar
  3. Golstein, J., Cantraine, F., Copinschi, G., L’Hermite, M., Pipeleers, D., Robyn, C., Velkeniens, B., and Vanhaelst, L., 1981, Effects of enkephalin infusion on hormonal levels in man: Inhibition of the episodic secretion of LH by methionine enkephalin, IRCS Med. Sci., 9: 218.Google Scholar
  4. Plotnikoff, N. P., Murgo, A. J., Miller, G. C., Corder, C. N., and Faith, R. E., 1985, Enkephalins: Immunomodulators, Fed. Proc., 44: 118.Google Scholar
  5. Prange, A. J. Jr., Wilson, J. C., Zara, P. P., Alltop, L, B., and Breese, G. R., 1972, Effects of thyrotropin-releasing hormone in depression, The Lancet, 2 (1): 999.Google Scholar
  6. Rolandi, E., Pescatore, D., Milesi, G. M., Gilberti, C., Sannia, A., and Barreca, T., 1980, Evaluation of LH, FSH, TSH, PRL, and GH secretion in patients suffering from prostatic neoplasms, Acta Endocrinol. ( Copenh ), 95: 23Google Scholar
  7. Von Graffenried, B., Del Pozo, E., Roubicek, J., Krebs, E., Poldinger, W., Burmeister, P., and Kerp, L., 1978, The effects of the synthetic enkephalin analogue FK 33–824 in man, Nature, 272: 729.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • N. P. Plotnikoff
    • 1
  • S. Solomon
    • 1
  • J. L. Valentine
    • 1
  • M. Fesen
    • 1
  • R. E. Faith
    • 1
  • L. Edwards
    • 1
  • R. Richter
    • 1
  • A. J. Murgo
    • 1
  • G. C. Miller
    • 2
  1. 1.Departments of Pharmacology and Medicine School of Medicine OralRoberts UniversityTulsaU.S.A
  2. 2.Immuno-Diagnostics LaboratoryTulsaU.S.A

Personalised recommendations