Neuropeptides are Chemoattractants for Human Monocytes and Tumor Cells: A Basis for Mind-Body Communication

  • Michael R. Ruff
  • Candace B. Pert


Monocytes, or their non-circulating counterparts, macrophages, are a heterogeneous population of cells which regulate many aspects of immune functioning including antigen processing, T cell activation, lymphokine and antibody production, as well as defense against neoplastic cells’. Recently, several other cell types, histologically and morphologically different from classical macrophages, have come to be included into this family of cells. They include the several minor cell populations present in skin (called Langerhans cells), brain (microglia), and dendritic cells sparsely distributed throughout basal epithelial layers of numerous organs and endocrine tissues2, as well as osteoclasts in joints. The functions of these macrophages are less clear although a role of the Langerhans cell in local immune reactions has been inferred.


Small Cell Lung Cancer Human Monocyte Stimulation Index Migration Index Monocyte Chemotaxis 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Michael R. Ruff
    • 1
    • 2
  • Candace B. Pert
    • 1
    • 2
  1. 1.Cellular Immunology Section, Laboratory of Microbiology and ImmunologyNational Institute of Dental Research, NIHUSA
  2. 2.Clinical Neuroscience Branch, NIMHSection on Brain BiochemistryBethesdaUSA

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