Implications Involving Autoimmune Mechanisms to the PCP Receptor in Schizophrenia

  • H. D. Whitten
  • K. Y. Tsang
  • P. Arnaud
  • N. K. Khansari
  • H. H. Fudenberg


Substantial evidence indicates that autoimmune mechanisms may either accompany or even precipitate some forms of psychoses. Such findings include: 1. Up to 50% of systemic lupus erythematosus (SLE) patients demonstrate some kind of neuropsychiatric disease; the most commom symptom (psychotic alteration in behavior or thinking) is not due to any known pre-existing psychiatric illness.1 2. The deposition of immune complexes in the choroid plexus is common in such cases and often has been shown to culminate ultimately in both DNA-anti-DNA antibody complexes in the cerebrospinal fluid (CSF)2 and lymphocytic perivascular cuffing of small blood vessels in the frontal cortex and hippocampus.1 Interestingly, although CNS involvement usually develops late in the course of SLE, it often occurs early and can appear as a sporadic disturbance of mental function.3 Thus, evidence exists supporting the concept of altered blood-brain barrier permeability accompanying immune complex disease.1,4 In fact, Rudin has suggested that every SLE patient would develop psychosis if other lethal complications were avoided.5 3. Anti-brain antibodies are commonly detected in SLE and schizophrenia. Bluestein6 reported that 78% of SLE sera contain IgM antineuronal antibody and 17% had IgG antineuronal antibody. Antibrain antibodies have been detected in the sera and sometimes the CSF of 48% of schizophrenics by Pandey and co-workers.7 Others have found 17%, 25%, 21%, 29%, 86%, and 63%8–14 depending on the sensitivity of the test utilized for antibody detection. One of the most interesting studies came from Luria and Domashneva15 in which sera (1:32 dilution) of schizophrenics demonstrated a 100% positive immunofluorescence toward mouse thymocytes in contrast to no reactivity from healthy donors. This finding was later confirmed and extended by Goldstein et al.16


Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Choroid Plexus Sigma Receptor Antineuronal Antibody 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • H. D. Whitten
    • 1
  • K. Y. Tsang
    • 1
  • P. Arnaud
    • 1
  • N. K. Khansari
    • 1
  • H. H. Fudenberg
    • 1
  1. 1.Department of Basic and Clinical ImmunologyMedical University of South CarolinaCharlestonUSA

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