Significant Role of Receptor Coupling in the Neuropeptide-Induced Alterations of Macrophage Cytotoxicity

  • Gabriella Foris
  • George A. Medgyesi
  • Jozsef I. Szekely

Abstract

Although in 1975 (Hughes et al., 1975) the year of discovery of the endogenous opiates, great expectations accompanied the research of these peptides, our knowledge regarding the central and peripheric effects of these compounds remain incomplete and superficial. Presumably the unexpected difficulties are due partly to the fact that the “secret” of the complex function of the opiate receptors has not been revealed, and on the other hand, some smaller peptide hormones derived from the large precursor molecules and displaying various biological effects could always confuse the interpretation of the essential processes.

Keywords

Adenylate Cyclase Opioid Peptide Intracellular cAMP Level Adenylate Cyclase System Chemotactic Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Gabriella Foris
    • 1
  • George A. Medgyesi
    • 2
  • Jozsef I. Szekely
    • 3
  1. 1.First Department of MedicineUniversity Medical SchoolDebrecenHungary
  2. 2.Institute of Heaematology and Blood TransfusionBudapestHungary
  3. 3.Institute for Drug ResearchBudapestHungary

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