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Immunosuppressive Effects of the Opiopeptins

  • Hulon W. McCain
  • Ira B. Lamster
  • Joanne Bilotta

Abstract

The immune system has long been considered an organ system differing significantly from others in the immediacy of its regulation by the central nervous system. Whereas other organs have, to differing degrees, well characterized neural and hormonal afferent as well as efferent regulatory pathways, immune function has traditionally been viewed as an internally regulated effector system essentially devoid of CNS modulation with the possible exception of the CRF-ACTHcorticosteroid link. Such views were reinforced by Jerne’s natural antibody selection theory (Jerne, 1955), and the observed ability of immune elements to display significant levels of activity in varied in vitro assay systems (Nowell, 1960). Astute clinicians, however, have for centuries reported antecdotal evidence of increased disease susceptibility associated with diverse physiological and psychological stimuli (Shigami, 1919) including those of stress and emotional distress (Locke, 1982). Patients suffering stressful injury such as burns, and operative or accidental trauma, exhibit decreased immune responsiveness which is often well correlated with post-traumatic susceptibility to bacterial, viral and fungal infections (Constantian et al., 1977; Wolfe et al., 1981; Alexander, 1968; and Goodman et al., 1968). Cancer patients have generally suppressed immunocompetence and, conversely, a large body of experimental data indicates that stress reduces the rate of implanted tumor rejection (Visintaner et al., 1982), and increases tumor growth (Riley, 1981) along with other correlates of invasiveness (Shavit et al., 1983).

Keywords

Migration Inhibition Factor Adrenal Medulla Partially Purify Derivative Human Peripheral Blood Lymphocyte Migration Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Hulon W. McCain
    • 1
    • 2
  • Ira B. Lamster
    • 2
    • 3
  • Joanne Bilotta
    • 3
  1. 1.Departments of PharmacologyFairleigh Dickinson University School of DentistryHackensackUSA
  2. 2.Periodontics and Oral MedicineFairleigh Dickinson University School of DentistryHackensackUSA
  3. 3.The Oral Health Research CenterFairleigh Dickinson University School of DentistryHackensackUSA

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